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BIOHYBRID AND BIODEGRADABLE NANOVACCINES FOR CANCER IMMUNOTHERAPY

Publications

Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines

Auteurs: Ruoyu Cheng, Flavia Fontana, Junyuan Xiao, Zehua Liu, Patrícia Figueiredo, Mohammad-Ali Shahbazi, Shiqi Wang, Jing Jin, Giulia Torrieri, Jouni T. Hirvonen, Hongbo Zhang, Tongtong Chen, Wenguo Cui, Yong Lu, Hélder A. Santos
Publié dans: ACS Applied Materials & Interfaces, 12, 2020, Page(s) 44554–44562, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.0c15057

Artificially cloaked viral nanovaccine for cancer immunotherapy

Auteurs: Manlio Fusciello, Flavia Fontana, Siri Tähtinen, Cristian Capasso, Sara Feola, Beatriz Martins, Jacopo Chiaro, Karita Peltonen, Leena Ylösmäki, Erkko Ylösmäki, Firas Hamdan, Otto K. Kari, Joseph Ndika, Harri Alenius, Arto Urtti, Jouni T. Hirvonen, Hélder A. Santos, Vincenzo Cerullo
Publié dans: Nature Communications, 10/1, 2019, Page(s) 5747, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-13744-8

Superfast and controllable microfluidic inking of anti-inflammatory melanin-like nanoparticles inspired by cephalopods

Auteurs: Shiqi Wang, Saowanee Wannasarit, Patrícia Figueiredo, Jiachen Li, Alexandra Correia, Bing Xia, Ruedeekorn Wiwattanapatapee, Jouni Hirvonen, Dongfei Liu, Wei Li, Hélder A. Santos
Publié dans: Materials Horizons, 7/6, 2020, Page(s) 1573-1580, ISSN 2051-6347
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0mh00014k

Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Auteurs: Flavia Fontana, Manlio Fusciello, Christianne Groeneveldt, Cristian Capasso, Jacopo Chiaro, Sara Feola, Zehua Liu, Ermei M. Mäkilä, Jarno J. Salonen, Jouni T. Hirvonen, Vincenzo Cerullo, Hélder A. Santos
Publié dans: ACS Nano, 13/6, 2019, Page(s) 6477-6490, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.8b09613

Peptide-guided resiquimod-loaded lignin nanoparticles convert tumor-associated macrophages from M2 to M1 phenotype for enhanced chemotherapy

Auteurs: Patrícia Figueiredo, Anni Lepland, Pablo Scodeller, Flavia Fontana, Giulia Torrieri, Mattia Tiboni, Mohammad‐Ali Shahbazi, Luca Casettari, Mauri A. Kostiainen, Jouni Hirvonen, Tambet Teesalu, Hélder A. Santos
Publié dans: Acta Biomaterialia, in press, 2020, Page(s) 13, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2020.09.038

Tandem‐Mass‐Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition

Auteurs: Yunzhan Li, Zehua Liu, Li Li, Wenhua Lian, Yaohui He, Elbadry Khalil, Ermei Mäkilä, Wenzhong Zhang, Giulia Torrieri, Xueyan Liu, Jingyi Su, Yuanming Xiu, Flavia Fontana, Jarno Salonen, Jouni Hirvonen, Wen Liu, Hongbo Zhang, Hélder A. Santos, Xianming Deng
Publié dans: Advanced Science, 7/15, 2020, Page(s) 2001129, ISSN 2198-3844
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202001129

Engineered antibody-functionalized porous silicon nanoparticles for therapeutic targeting of pro-survival pathway in endogenous neuroblasts after stroke

Auteurs: Vimalkumar Balasubramanian, Andrii Domanskyi, Juho-Matti Renko, Mirkka Sarparanta, Chang-Fang Wang, Alexandra Correia, Ermei Mäkilä, Osku S. Alanen, Jarno Salonen, Anu J. Airaksinen, Raimo Tuominen, Jouni Hirvonen, Mikko Airavaara, Hélder A. Santos
Publié dans: Biomaterials, 227, 2020, Page(s) 119556, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119556

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Auteurs: Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, Abdul Hakeem, Jun Hu, Lu Gan, Hélder A. Santos, Xiangliang Yang
Publié dans: Nature Communications, 10/1, 2019, Page(s) 3838, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-019-11718-4

Hybrid red blood cell membrane coated porous silicon nanoparticles functionalized with cancer antigen induce depletion of T cells

Auteurs: Antti Rahikkala, Flavia Fontana, Tomás Bauleth-Ramos, Alexandra Correia, Marianna Kemell, Jani Seitsonen, Ermei Mäkilä, Bruno Sarmento, Jarno Salonen, Janne Ruokolainen, Jouni Hirvonen, Hélder A. Santos
Publié dans: RSC Advances, 10/58, 2020, Page(s) 35198-35205, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0ra05900e

A Virus‐Mimicking pH‐Responsive Acetalated Dextran‐Based Membrane‐Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics

Auteurs: Saowanee Wannasarit, Shiqi Wang, Patrícia Figueiredo, Claudia Trujillo, Francesca Eburnea, Lorena Simón‐Gracia, Alexandra Correia, Yaping Ding, Tambet Teesalu, Dongfei Liu, Ruedeekorn Wiwattanapatapee, Hélder A. Santos, Wei Li
Publié dans: Advanced Functional Materials, 29/51, 2019, Page(s) 1905352, ISSN 1616-301X
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201905352

Influence of Cell Membrane Wrapping on the Cell−Porous Silicon Nanoparticle Interactions

Auteurs: Flavia Fontana, Hanna Lindstedt, Alexandra Correia, Jacopo Chiaro, Otto K. Kari, Joseph Ndika, Harri Alenius, Jonas Buck, Sandro Sieber, Ermei Mäkilä, Jarno Salonen, Arto Urtti, Vincenzo Cerullo, Jouni T. Hirvonen, Hélder A. Santos
Publié dans: Advanced Healthcare Materials, 9/17, 2020, Page(s) 2000529, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202000529

Intracellular Delivery of Budesonide and Polydopamine Co‐Loaded in Endosomolytic Poly(butyl methacrylate‐ co ‐methacrylic acid) Grafted Acetalated Dextran for Macrophage Phenotype Switch from M1 to M2

Auteurs: Shiqi Wang, Saowanee Wannasarit, Patrícia Figueiredo, Giuseppina Molinaro, Yaping Ding, Alexandra Correia, Luca Casettari, Ruedeekorn Wiwattanapatapee, Jouni Hirvonen, Dongfei Liu, Wei Li, Hélder A. Santos
Publié dans: Advanced Therapeutics, in press, 2020, Page(s) 2000058, ISSN 2366-3987
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/adtp.202000058