BIOHYBRID AND BIODEGRADABLE NANOVACCINES FOR CANCER IMMUNOTHERAPY

Project Information

iNANOVAC4CANCER

Grant agreement ID: 825020

DOI

10.3030/825020

Project closed

EC signature date 12 November 2018

Start date 1 January 2019

End date 30 June 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 150 000,00

EU contribution

€ 150 000,00

Coordinated by

HELSINGIN YLIOPISTO
Finland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines

Author(s): Ruoyu Cheng, Flavia Fontana, Junyuan Xiao, Zehua Liu, Patrícia Figueiredo, Mohammad-Ali Shahbazi, Shiqi Wang, Jing Jin, Giulia Torrieri, Jouni T. Hirvonen, Hongbo Zhang, Tongtong Chen, Wenguo Cui, Yong Lu, Hélder A. Santos
Published in: ACS Applied Materials & Interfaces, Issue 12, 2020, Page(s) 44554–44562, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c15057

Artificially cloaked viral nanovaccine for cancer immunotherapy

Author(s): Manlio Fusciello, Flavia Fontana, Siri Tähtinen, Cristian Capasso, Sara Feola, Beatriz Martins, Jacopo Chiaro, Karita Peltonen, Leena Ylösmäki, Erkko Ylösmäki, Firas Hamdan, Otto K. Kari, Joseph Ndika, Harri Alenius, Arto Urtti, Jouni T. Hirvonen, Hélder A. Santos, Vincenzo Cerullo
Published in: Nature Communications, Issue 10/1, 2019, Page(s) 5747, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13744-8

Superfast and controllable microfluidic inking of anti-inflammatory melanin-like nanoparticles inspired by cephalopods

Author(s): Shiqi Wang, Saowanee Wannasarit, Patrícia Figueiredo, Jiachen Li, Alexandra Correia, Bing Xia, Ruedeekorn Wiwattanapatapee, Jouni Hirvonen, Dongfei Liu, Wei Li, Hélder A. Santos
Published in: Materials Horizons, Issue 7/6, 2020, Page(s) 1573-1580, ISSN 2051-6347
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0mh00014k

Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Author(s): Flavia Fontana, Manlio Fusciello, Christianne Groeneveldt, Cristian Capasso, Jacopo Chiaro, Sara Feola, Zehua Liu, Ermei M. Mäkilä, Jarno J. Salonen, Jouni T. Hirvonen, Vincenzo Cerullo, Hélder A. Santos
Published in: ACS Nano, Issue 13/6, 2019, Page(s) 6477-6490, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b09613

Peptide-guided resiquimod-loaded lignin nanoparticles convert tumor-associated macrophages from M2 to M1 phenotype for enhanced chemotherapy

Author(s): Patrícia Figueiredo, Anni Lepland, Pablo Scodeller, Flavia Fontana, Giulia Torrieri, Mattia Tiboni, Mohammad‐Ali Shahbazi, Luca Casettari, Mauri A. Kostiainen, Jouni Hirvonen, Tambet Teesalu, Hélder A. Santos
Published in: Acta Biomaterialia, Issue in press, 2020, Page(s) 13, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.09.038

Tandem‐Mass‐Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition

Author(s): Yunzhan Li, Zehua Liu, Li Li, Wenhua Lian, Yaohui He, Elbadry Khalil, Ermei Mäkilä, Wenzhong Zhang, Giulia Torrieri, Xueyan Liu, Jingyi Su, Yuanming Xiu, Flavia Fontana, Jarno Salonen, Jouni Hirvonen, Wen Liu, Hongbo Zhang, Hélder A. Santos, Xianming Deng
Published in: Advanced Science, Issue 7/15, 2020, Page(s) 2001129, ISSN 2198-3844
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/advs.202001129

Engineered antibody-functionalized porous silicon nanoparticles for therapeutic targeting of pro-survival pathway in endogenous neuroblasts after stroke

Author(s): Vimalkumar Balasubramanian, Andrii Domanskyi, Juho-Matti Renko, Mirkka Sarparanta, Chang-Fang Wang, Alexandra Correia, Ermei Mäkilä, Osku S. Alanen, Jarno Salonen, Anu J. Airaksinen, Raimo Tuominen, Jouni Hirvonen, Mikko Airavaara, Hélder A. Santos
Published in: Biomaterials, Issue 227, 2020, Page(s) 119556, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119556

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Author(s): Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, Abdul Hakeem, Jun Hu, Lu Gan, Hélder A. Santos, Xiangliang Yang
Published in: Nature Communications, Issue 10/1, 2019, Page(s) 3838, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11718-4

Hybrid red blood cell membrane coated porous silicon nanoparticles functionalized with cancer antigen induce depletion of T cells

Author(s): Antti Rahikkala, Flavia Fontana, Tomás Bauleth-Ramos, Alexandra Correia, Marianna Kemell, Jani Seitsonen, Ermei Mäkilä, Bruno Sarmento, Jarno Salonen, Janne Ruokolainen, Jouni Hirvonen, Hélder A. Santos
Published in: RSC Advances, Issue 10/58, 2020, Page(s) 35198-35205, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0ra05900e

A Virus‐Mimicking pH‐Responsive Acetalated Dextran‐Based Membrane‐Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics

Author(s): Saowanee Wannasarit, Shiqi Wang, Patrícia Figueiredo, Claudia Trujillo, Francesca Eburnea, Lorena Simón‐Gracia, Alexandra Correia, Yaping Ding, Tambet Teesalu, Dongfei Liu, Ruedeekorn Wiwattanapatapee, Hélder A. Santos, Wei Li
Published in: Advanced Functional Materials, Issue 29/51, 2019, Page(s) 1905352, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201905352

Influence of Cell Membrane Wrapping on the Cell−Porous Silicon Nanoparticle Interactions

Author(s): Flavia Fontana, Hanna Lindstedt, Alexandra Correia, Jacopo Chiaro, Otto K. Kari, Joseph Ndika, Harri Alenius, Jonas Buck, Sandro Sieber, Ermei Mäkilä, Jarno Salonen, Arto Urtti, Vincenzo Cerullo, Jouni T. Hirvonen, Hélder A. Santos
Published in: Advanced Healthcare Materials, Issue 9/17, 2020, Page(s) 2000529, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202000529

Intracellular Delivery of Budesonide and Polydopamine Co‐Loaded in Endosomolytic Poly(butyl methacrylate‐ co ‐methacrylic acid) Grafted Acetalated Dextran for Macrophage Phenotype Switch from M1 to M2

Author(s): Shiqi Wang, Saowanee Wannasarit, Patrícia Figueiredo, Giuseppina Molinaro, Yaping Ding, Alexandra Correia, Luca Casettari, Ruedeekorn Wiwattanapatapee, Jouni Hirvonen, Dongfei Liu, Wei Li, Hélder A. Santos
Published in: Advanced Therapeutics, Issue in press, 2020, Page(s) 2000058, ISSN 2366-3987
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adtp.202000058