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Genome, Environment, Microbiome & Metabolome in Autism: an integrated multi-omic systems biology approach to identify biomarkers for personalized treatment and primary prevention of Autism Spectr

Project description

A combined approach to identifying potential biomarkers for autism spectrum disorders

Autism spectrum disorders (ASD) affect around 1 in 54 children and can cause significant social, communication and behavioural challenges. Currently, there are no proven ASD biomarkers; diagnosis relies entirely on behavioural evaluations. The EU-funded GEMMA project plans to combine for the first time multi-omics with environmental data for analysing the composition and function of the microbiome for personalised treatment, and ultimately, disease interception in at-risk infants. The goal is to provide solid insight into ASD onset and its progression in relation to dynamic changes in abnormal gut microbiota and develop targets for possible treatment and prevention. Observations of these epigenetic modifications that control gut barrier and immune functions will be based on in-depth evaluation of 600 infants at risk observed from birth and thereafter.

Call for proposal

H2020-SC1-BHC-2018-2020

See other projects for this call

Sub call

H2020-SC1-2018-Single-Stage-RTD

Coordinator

FONDAZIONE EBRIS
Net EU contribution
€ 2 035 531,25
Address
Via De Renzi 1
84125 Salerno
Italy
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (15)

NUTRICIA RESEARCH BV
Netherlands
Net EU contribution
€ 812 423,75
Address
Uppsalalaan 12
3584 CT Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MEDINOK SPA
Italy
Net EU contribution
€ 549 375,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Via Palazziello Snc
80040 Volla
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
BIO MODELING SYSTEMS OU BMSYSTEMS
France
Net EU contribution
€ 548 125,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
3 Rue De L'arrivee
75015 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Ile-de-France Ile-de-France Paris
 
EUFORMATICS OY
Finland
Net EU contribution
€ 728 437,50
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Tekniikantie 12
02150 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
THEOREO SRL
Italy
Net EU contribution
€ 426 250,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Via Degli Ulivi, 3
84090 Montecorvino Pugliano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
Net EU contribution
€ 1 663 750,00
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AZIENDA SANITARIA LOCALE SALERNO
Italy
Net EU contribution
€ 1 133 375,00
Address
Via Nizza 146
84124 Salerno
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
THE GENERAL HOSPITAL CORPORATION
United States
Net EU contribution
€ 1 256 468,75
Address
Fruit Street 55
02114 Boston Ma
Activity type
Other
Non-EU contribution
€ 0,00
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Net EU contribution
€ 544 375,00
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
Net EU contribution
€ 1 060 617,50
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 447 762,50
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITEIT UTRECHT
Netherlands
Net EU contribution
€ 881 116,25
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TAMPEREEN KORKEAKOULUSAATIO SR
Finland
Net EU contribution
€ 558 125,00
Address
Kalevantie 4
33100 Tampere
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 832 812,50
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
JOHNS HOPKINS UNIVERSITY
United States
Net EU contribution
€ 747 212,50
Address
North Charles Street 3400
21218 Baltimore
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00