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CORDIS - Resultados de investigaciones de la UE
CORDIS

Genome, Environment, Microbiome & Metabolome in Autism: an integrated multi-omic systems biology approach to identify biomarkers for personalized treatment and primary prevention of Autism Spectr

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Report on the participation to the IHMC congress in Barcelona 2020 (se abrirá en una nueva ventana)

Report on the outcomes of the participation of GEMMA at the 8th International Human Microbiome Congress in 2020 (Barcelona)

Final clinical protocols (se abrirá en una nueva ventana)

Study protocols to submit for the approbation to the ethical committee

Pre-clinical study 2 report (se abrirá en una nueva ventana)

A report providing the results of the trial 2 to investigate if the ASD phenotype is dependent on microbiome-induced systemic immune activation, via adoptive splenocyte transfer studies

Theoretical qualitative models of ASD pathogenesis mechanisms (se abrirá en una nueva ventana)

A model specifically detail the mechanisms whereby alterations in gut microbiome may lead to persistent, low-grade feverless systemic inflammation and how this could then affect CNS metabolism and neuronal arborescence preferentially in male developing infants

Pre-clinical study 3/2 report (se abrirá en una nueva ventana)

A second report providing the results of trial 3 to establish whether correction of dysbiosis by pre/pro/symbiotic intervention prevents and/or treats increased the impaired gut permeability, changes in metabolic profile, modification of the immune response, and, ultimately, the onset of ASD behavioural symptoms in humanized murine models of ASD (mice transplanted with faecal bacterial content of ASD patient donor sample

Pre-clinical study ethical approval report (se abrirá en una nueva ventana)

A study protocol to submit for the approbation to the ethical committee

Pre-clinical study 1 report (se abrirá en una nueva ventana)

A report providing the results of the the trial 1 focus on exploring if the behavioural phenotype of ASD patients is transferrable to mice via faecal transplantation

Genome, epigenome and immune function interplay summary of hypothesis (se abrirá en una nueva ventana)

An hypothesis regarding how the genome/metagenome interplay is responsible for the switch from immune tolerance to immune response to environmental stimuli (antigens) including dietary and microbial factors leading to neuroinflammation responsible of behavioural changes that characterize ASD and gut inflammation causing its GI co-morbidities

Pre-clinical study 3/3 report (se abrirá en una nueva ventana)

A third report providing the results of trial 3 to establish whether correction of dysbiosis by pre/pro/symbiotic intervention prevents and/or treats increased the impaired gut permeability, changes in metabolic profile, modification of the immune response, and, ultimately, the onset of ASD behavioural symptoms in humanized murine models of ASD (mice transplanted with faecal bacterial content of ASD patient donor sample

Updated state of the art report (se abrirá en una nueva ventana)

Report providing a brief relation about the state of the art in the ASD biomarker and therapy

Microbiome, metabolome and immune function interplay summary of hypothesis (se abrirá en una nueva ventana)

An hypothesis regarding how the gut bacterial dysbiosis leads to epigenetic modifications, changes in metabolic profiles, increased gut permeability, increased antigen trafficking and, ultimately to altered immune responses to promote disease in a subset of individuals at-risk of ASD

Pre-clinical study 3/1 report (se abrirá en una nueva ventana)

A first report providing the results of trial 3 to establish whether correction of dysbiosis by pre/pro/symbiotic intervention prevents and/or treats increased the impaired gut permeability, changes in metabolic profile, modification of the immune response, and, ultimately, the onset of ASD behavioural symptoms in humanized murine models of ASD (mice transplanted with faecal bacterial content of ASD patient donor sample

First release of the multi-omics platform (pre-clinical trials) (se abrirá en una nueva ventana)

An algorithms able to associate various biomarker levels observed in infants with ASD and GI symptoms. This alghorithm will use advanced statistical analysis methods such as sparse canonical correlation (a linear correlation method) combined with random forests (a non-linear correlation method) to detect these associations between the omics data.

Second release of the multi-omics platform (observational trials) (se abrirá en una nueva ventana)

An analysis of the fitting between the correlations put forward by the multi-omics analyses and the biological outcome of the interventional part of the observational study

OmnomicsNGS v2 release (se abrirá en una nueva ventana)

A new relase of the software OmnomicsNGS including a tool for dynamic variant analysis and interpretation

External project website (se abrirá en una nueva ventana)

Project website: project description, public deliverables, scientific news, other

Publicaciones

An integrative network analysis framework for identifying molecular functions in complex disorders examining major depressive disorder as a test case. (se abrirá en una nueva ventana)

Autores: Oommen AM, Cunningham S, O'Súilleabháin PS, Hughes BM, Joshi L
Publicado en: Scientific Reports, Edición (2021) 11:9645, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-89040-7

Neurotensin-Binding Immunoglobulin G in Patients with Parkinson’s Disease (se abrirá en una nueva ventana)

Autores: Muruzheva ZM, Egorov DS, Absalyamova MT, Traktirov DS, Karpenko MN, and Fetissov SO
Publicado en: Neuroimmunomodulation, Edición 30(1), 2023, Página(s) 15-27, ISSN 1021-7401
Editor: S. Karger AG
DOI: 10.1159/000527872

Mechanisms of Glucose Absorption in the Small Intestine in Health and Metabolic Diseases and Their Role in Appetite Regulation (se abrirá en una nueva ventana)

Autores: Lyudmila V. Gromova, Serguei O. Fetissov, Andrey A. Gruzdkov
Publicado en: Nutrients, Edición 13/7, 2021, Página(s) 2474, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13072474

Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder (se abrirá en una nueva ventana)

Autores: Naika Prince, Lucia N Peralta Marzal, Anastasia Markidi, Sabbir Ahmed, Youri Adolfs, R Jeroen Pasterkamp, Himanshu Kumar, Guus Roeselers, Johan Garssen, Aletta D Kraneveld, Paula Perez-Pardo
Publicado en: Acta Pharmacologica Sinica, Edición 45, 2024, Página(s) 1591-1603, ISSN 1671-4083
Editor: Shanghai Institute of Materia Medica
DOI: 10.1038/s41401-024-01268-x

Network Diffusion Promotes the Integrative Analysis of Multiple Omics (se abrirá en una nueva ventana)

Autores: Noemi Di Nanni, Matteo Bersanelli, Luciano Milanesi, Ettore Mosca
Publicado en: Frontiers in Genetics, Edición 11, 2020, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2020.00106

Analysis of Faecal Microbiota and Small ncRNAs in Autism: Detection of miRNAs and piRNAs with Possible Implications in Host-Gut Microbiota Cross-Talk (se abrirá en una nueva ventana)

Autores: Chiappori F., Cupaioli F.A., Consiglio A., Di Nanni N., Mosca E., Licciulli V.F., Mezzelani A.
Publicado en: Nutrients, Edición 14(7):1340, 2022 Mar 23, 2022, Página(s) 1-23, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14071340

Microbiota influence on behavior: Integrative analysis of serotonin metabolism and behavioral profile in germ‐free mice (se abrirá en una nueva ventana)

Autores: Léa Roussin, Elisa Gry, Mira Macaron, Sandy Ribes, Magali Monnoye, Véronique Douard, Laurent Naudon, Sylvie Rabot
Publicado en: The FASEB Journal, Edición 38, 2024, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202400334r

The interaction between intestinal bacterial metabolites and phosphatase and tensin homolog in autism spectrum disorder (se abrirá en una nueva ventana)

Autores: Zheng Y, Prince N, van Hattem C, Garssen J, Pardo PP, Kraneveld AD
Publicado en: Molecular and Celullar Neuroscience, Edición Dec 30;124:103805, 2023, Página(s) 1-11, ISSN 1044-7431
Editor: Academic Press
DOI: 10.1016/j.mcn.2022.103805

The role of bacterial-derived aromatic amino acids metabolites relevant in autism spectrum disorders: A comprehensive review (se abrirá en una nueva ventana)

Autores: Yuanpeng Zheng, Marie K Bek, Naika Z Prince, Lucia N Peralta Marzal, Johan Garssen, Paula Perez Pardo, Aletta D Kraneveld
Publicado en: Frontiers in Neuroscience, Edición October, 2021, Página(s) 1401, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2021.738220

Autonomic Nervous System Neuroanatomical Alterations Could Provoke and Maintain Gastrointestinal Dysbiosis in Autism Spectrum Disorder (ASD): A Novel Microbiome–Host Interaction Mechanistic Hypothesis (se abrirá en una nueva ventana)

Autores: Athanasios Beopoulos, Manuel Gea, Alessio Fasano, François Iris
Publicado en: Nutrients, 2021, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu14010065

Assessment of haptoglobin alleles in autism spectrum disorders (se abrirá en una nueva ventana)

Autores: Cupaioli FA, Mosca E, Magri C, Gennarelli M, Moscatelli M, Raggi ME, Landini M, Galluccio N, Villa L, Bonfanti A, Renieri A, Fallerini C, Minelli A, Marabotti A, Milanesi L, Fasano A, Mezzelani A
Publicado en: Scientific Reports, Edición 10(1):7758, 2020 May 8, 2020, Página(s) 1-11, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-64679-w

Lactobacillus salivarius and Lactobacillus gasseri supplementation reduces stress-induced sugar craving in mice (se abrirá en una nueva ventana)

Autores: Nicol M., Lahaye E., El Mehdi M., do Rego J.-L., do Rego J.-C., Fetissov S.O.
Publicado en: European Eating Disorders Review, 2023, ISSN 1099-0968
Editor: Wiley
DOI: 10.1002/erv.3004

The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders (se abrirá en una nueva ventana)

Autores: Lucía N. Peralta-Marzal, Naika Prince, Djordje Bajic, Léa Roussin, Laurent Naudon, Sylvie Rabot, Johan Garssen, Aletta D. Kraneveld and Paula Perez-Pardo
Publicado en: International Journal of Molecular Sciences, Edición Volume 22, Edición 18, 2021, semimonthly, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810052

The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17 (se abrirá en una nueva ventana)

Autores: Yuanpeng Zheng, Tessa A. Verhoeff, Paula Perez Pardo, Johan Garssen and Aletta D. Kraneveld
Publicado en: International Journal of Molecular Sciences, Edición volume 22, issue 1, 2021, semimonthly, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010118

The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10 (se abrirá en una nueva ventana)

Autores: Zheng, Y.; Prince, N.Z.; Peralta Marzal, L.N.; Ahmed, S.; Garssen, J.; Perez Pardo, P.; Kraneveld, A.D.
Publicado en: Int J Mol Sci, Edición Sep 20;23(19):11013, 2022, Página(s) 1-17, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms231911013

Autism Spectrum Disorders: Analysis of Mobile Elements at 7q11.23 Williams–Beuren Region by Comparative Genomics (se abrirá en una nueva ventana)

Autores: Francesca Anna Cupaioli, Chiara Fallerini, Maria Antonietta Mencarelli, Valentina Perticaroli, Virginia Filippini, Francesca Mari, Alessandra Renieri, Alessandra Mezzelani
Publicado en: Genes, Edición 12/10, 2021, Página(s) 1605, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12101605

Characterization and comparison of gene-centered human interactomes (se abrirá en una nueva ventana)

Autores: Ettore Mosca, Matteo Bersanelli, Tommaso Matteuzzi, Noemi Di Nanni, Gastone Castellani, Luciano Milanesi, Daniel Remondini
Publicado en: Briefings in Bioinformatics, 2021, ISSN 1467-5463
Editor: Oxford University Press
DOI: 10.1093/bib/bbab153

A robust microbiome signature for autism spectrum disorder across different studies using machine learning (se abrirá en una nueva ventana)

Autores: Lucia N. Peralta-Marzal, David Rojas-Velazquez, Douwe Rigters, Naika Prince, Johan Garssen, Aletta D. Kraneveld, Paula Perez-Pardo, Alejandro Lopez-Rincon
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-50601-7

Protein extract of a probiotic strain Hafnia alvei and bacterial ClpB protein improve glucose tolerance in mice (se abrirá en una nueva ventana)

Autores: Zolotarev V.A., Murovets V.O., Sepp A.L., Sozontov E.A., Lukina E.A., Khropycheva R.P., Pestereva N.S., Ivleva I.S., El Mehdi M., Lahaye E., Chartrel N., Fetissov S.O.
Publicado en: International Journal of Molecular Sciences, Edición 24(13), 10590, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241310590

Genome, Environment, Microbiome and Metabolome in Autism (GEMMA) Study Design: Biomarkers Identification for Precision Treatment and Primary Prevention of Autism Spectrum Disorders by an Integrated Multi-Omics Systems Biology Approach (se abrirá en una nueva ventana)

Autores: Jacopo Troisi, Reija Autio, Thanos Beopoulos, Carmela Bravaccio, Federica Carraturo, Giulio Corrivetti, Stephen Cunningham, Samantha Devane, Daniele Fallin, Serguei Fetissov, Manuel Gea, Antonio Giorgi, François Iris, Lokesh Joshi, Sarah Kadzielski, Aletta Kraneveld, Himanshu Kumar, Christine Ladd-Acosta, Geraldine Leader, Arlene Mannion, Elise Maximin, Alessandra Mezzelani, Luciano Milanesi, Lau
Publicado en: Brain Sciences, Edición 10/10, 2020, Página(s) 743, ISSN 2076-3425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci10100743

Gut Reactions: How Far Are We from Understanding and Manipulating the Microbiota Complexity and the Interaction with Its Host? Lessons from Autism Spectrum Disorder Studies (se abrirá en una nueva ventana)

Autores: Martina Lombardi, Jacopo Troisi
Publicado en: Nutrients, Edición 13/10, 2021, Página(s) 3492, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13103492

Change of Communication Strategy to Increase Engagement during the SARS-Cov-2Pandemic: The Experience of the European GEMMA Project in Italy (se abrirá en una nueva ventana)

Autores: Cupaioli Francesca Anna, Corrivetti Giulio, Tamburro Ilaria, Fasano Alessio, Mezzelani Alessandra
Publicado en: International Journal of Humanities, Social Sciences and Education, Edición 7/9, 2020, ISSN 2349-0381
Editor: ARC Publications Pvt Ltd
DOI: 10.20431/2349-0381.0709013

Network-Based Integrative Analysis of Genomics, Epigenomics and Transcriptomics in Autism Spectrum Disorders (se abrirá en una nueva ventana)

Autores: Noemi Di Nanni, Matteo Bersanelli, Francesca Anna Cupaioli, Luciano Milanesi, Alessandra Mezzelani, Ettore Mosca
Publicado en: International Journal of Molecular Sciences, Edición 20/13, 2019, Página(s) 3363, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20133363

Role of the Gut Microbiota in the Pathophysiology of Autism Spectrum Disorder: Clinical and Preclinical Evidence (se abrirá en una nueva ventana)

Autores: Léa Roussin, Naika Prince, Paula Perez-Pardo, Aletta D. Kraneveld, Sylvie Rabot, Laurent Naudon
Publicado en: Microorganisms, Edición 8/9, 2020, Página(s) 1369, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms8091369

Blood levels of neuropeptide 26RFa in relation to anxiety and aggressive behavior in humans - an exploratory study (se abrirá en una nueva ventana)

Autores: Værøy H., Takhlidjt S., Cherifi Y., Lahaye E., Chartrel N., Fetissov S.O.
Publicado en: Brain Sciences, Edición 13(2), 237, 2023, ISSN 2076-3425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci13020237

Immunoglobulin G is a natural oxytocin carrier which modulates oxytocin receptor signaling - relevance to aggressive behavior in humans (se abrirá en una nueva ventana)

Autores: Værøy H., Lahaye E., Dubessy C., Benard M., Nicol M., Cherifi Y., Takhlidjt S., do Rego J.-L., do Rego J.-C., Chartrel N., Fetissov S.O.
Publicado en: Discover Mental Health, Edición Oct 19;3(1):21, 2023, Página(s) Volume 3, article number 21, ISSN 2731-4383
Editor: Springer
DOI: 10.1007/s44192-023-00048-z

Autism spectrum disorders pathogenesis: Toward a comprehensive model based on neuroanatomic and neurodevelopment considerations (se abrirá en una nueva ventana)

Autores: Beopoulos A, Géa M, Fasano A, Iris F
Publicado en: Frontiers in neuroscience, Edición Nov 03 3;16:988735, 2022, Página(s) 1-24, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2022.988735

Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism (se abrirá en una nueva ventana)

Autores: Naika Prince, Lucia N. Peralta Marzal, Léa Roussin, Magali Monnoye, Catherine Philippe, Elise Maximin, Sabbir Ahmed, Karoliina Salenius, Jake Lin, Reija Autio, Youri Adolfs, R. Jeroen Pasterkamp, Johan Garssen, Laurent Naudon, Sylvie Rabot, Aletta D. Kraneveld, Paula Perez-Pardo
Publicado en: Gut Microbes, Edición 17, 2025, ISSN 1949-0976
Editor: Landes Bioscience
DOI: 10.1080/19490976.2024.2447822

Gene relevance based on multiple evidences in complex networks (se abrirá en una nueva ventana)

Autores: Noemi Di Nanni, Matteo Gnocchi, Marco Moscatelli, Luciano Milanesi, Ettore Mosca
Publicado en: Bioinformatics, 2019, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btz652

Transcriptomic Analysis of Respiratory Tissue and Cell Line Models to Examine Glycosylation Machinery during SARS-CoV-2 Infection (se abrirá en una nueva ventana)

Autores: Oommen A, Cunningham S, Joshi L.
Publicado en: Viruses, Edición Jan 8;13(1):82, 2021, Página(s) 1-15, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13010082

Food, nutrition, and autism: from soil to fork (se abrirá en una nueva ventana)

Autores: Melissa Maitin-Shepard, Perrie O’Tierney-Ginn, Aletta D Kraneveld, Kristen Lyall, Daniele Fallin, Manish Arora, Alessio Fasano, Noel T Mueller, Xiaobin Wang, Laura E Caulfield, Aisha S Dickerson, Rochellys Diaz Heijtz, Tomo Tarui, Jeffrey B Blumberg, Calliope Holingue, Rebecca J Schmidt, Johan Garssen, Katherine Almendinger, Pi-I Debby Lin, Dariush Mozaffarian
Publicado en: The American Journal of Clinical Nutrition, Edición 120, 2025, Página(s) 240-256, ISSN 0002-9165
Editor: American Society for Clinical Nutrition, Inc.
DOI: 10.1016/j.ajcnut.2024.04.020

Genome, Environment, Microbiome and Metabolome in Autism (GEMMA) Study: Beyond biomarker identification for the precision treatment and early detection of autism spectrum disorders (se abrirá en una nueva ventana)

Autores: J. Troisi, M. Lombardi, SJK Symes, G. Scala, M. Delli Carri, SM Richards & GEMMA Consortium
Publicado en: Bioinformatics and Computational Biology Conference, 2022
Editor: F1000 Research
DOI: 10.7490/f1000research.1119307.1

Progress in the Puzzle Resolution: The Molecular Genetics Underpinning Autism Spectrum Disorders (se abrirá en una nueva ventana)

Autores: Mezzelani A, Cupaioli F.A.
Publicado en: Brain Science, Edición 2023 Dec 7;13(12):1688, 2023, ISSN 2076-3425
Editor: MDPI
DOI: 10.3390/brainsci13121688

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder (se abrirá en una nueva ventana)

Autores: Brittany D. Needham, Mark D. Adame, Gloria Serena, Destanie R. Rose, Gregory M. Preston, Mary C. Conrad, A. Stewart Campbell, David H. Donabedian, Alessio Fasano, Paul Ashwood, Sarkis K. Mazmanian
Publicado en: Journal Biological Psychiatry, Edición Volume 89, Edición 5, 2021, Página(s) 451-462, ISSN 0006-3223
Editor: Elsevier
DOI: 10.1016/j.biopsych.2020.09.025

Gut Microbiota-Brain Axis in Regulation of Feeding Behavior (se abrirá en una nueva ventana)

Autores: Fetissov SO
Publicado en: Microorganisms, Edición 11(3), 749, 2023, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms11030749

Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis (se abrirá en una nueva ventana)

Autores: Asbjornsdottir, B.; Snorradottir, H.; Andresdottir, E.; Fasano, A.; Lauth, B.; Gudmundsson, L.S.; Gottfredsson, M.; Halldorsson, T.I.; Birgisdottir, B.E.
Publicado en: Nutrients, Edición Jul 3;12(7):1982, 2020, Página(s) 1-27, ISSN 2072-6643
Editor: MDPI
DOI: 10.3390/nu12071982

Optimization of Peripheral Blood Mononuclear Cell Extraction from Small Volume of Blood Samples: Potential Implications for Children-Related Diseases (se abrirá en una nueva ventana)

Autores: Patrone, D.; Alessio, N.; Antonucci, N.; Brigida, A.L.; Peluso, G.; Galderisi, U.; Siniscalco, D.
Publicado en: Journal Methods Protoc, Edición Feb 24;5(2):20, 2022, Página(s) 1-6, ISSN 2409-9279
Editor: MDPI
DOI: 10.3390/mps5020020

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