Resultado final
Report on the outcomes of the participation of GEMMA at the 8th International Human Microbiome Congress in 2020 (Barcelona)
Final clinical protocolsStudy protocols to submit for the approbation to the ethical committee
Pre-clinical study 2 reportA report providing the results of the trial 2 to investigate if the ASD phenotype is dependent on microbiome-induced systemic immune activation, via adoptive splenocyte transfer studies
Theoretical qualitative models of ASD pathogenesis mechanismsA model specifically detail the mechanisms whereby alterations in gut microbiome may lead to persistent, low-grade feverless systemic inflammation and how this could then affect CNS metabolism and neuronal arborescence preferentially in male developing infants
Pre-clinical study ethical approval reportA study protocol to submit for the approbation to the ethical committee
Pre-clinical study 1 reportA report providing the results of the the trial 1 focus on exploring if the behavioural phenotype of ASD patients is transferrable to mice via faecal transplantation
Genome, epigenome and immune function interplay summary of hypothesisAn hypothesis regarding how the genome/metagenome interplay is responsible for the switch from immune tolerance to immune response to environmental stimuli (antigens) including dietary and microbial factors leading to neuroinflammation responsible of behavioural changes that characterize ASD and gut inflammation causing its GI co-morbidities
Updated state of the art reportReport providing a brief relation about the state of the art in the ASD biomarker and therapy
Microbiome, metabolome and immune function interplay summary of hypothesisAn hypothesis regarding how the gut bacterial dysbiosis leads to epigenetic modifications, changes in metabolic profiles, increased gut permeability, increased antigen trafficking and, ultimately to altered immune responses to promote disease in a subset of individuals at-risk of ASD
Pre-clinical study 3/1 reportA first report providing the results of trial 3 to establish whether correction of dysbiosis by pre/pro/symbiotic intervention prevents and/or treats increased the impaired gut permeability, changes in metabolic profile, modification of the immune response, and, ultimately, the onset of ASD behavioural symptoms in humanized murine models of ASD (mice transplanted with faecal bacterial content of ASD patient donor sample
An algorithms able to associate various biomarker levels observed in infants with ASD and GI symptoms. This alghorithm will use advanced statistical analysis methods such as sparse canonical correlation (a linear correlation method) combined with random forests (a non-linear correlation method) to detect these associations between the omics data.
Second release of the multi-omics platform (observational trials)An analysis of the fitting between the correlations put forward by the multi-omics analyses and the biological outcome of the interventional part of the observational study
OmnomicsNGS v2 releaseA new relase of the software OmnomicsNGS including a tool for dynamic variant analysis and interpretation
GEMMA participation on H2020 open data pilot
Project website: project description, public deliverables, scientific news, other
Publicaciones
Autores:
Oommen AM, Cunningham S, O'Súilleabháin PS, Hughes BM, Joshi L
Publicado en:
Scientific Reports, Edición (2021) 11:9645, 2021, ISSN 2045-2322
Editor:
Nature Publishing Group
DOI:
10.1038/s41598-021-89040-7
Autores:
Muruzheva ZM, Egorov DS, Absalyamova MT, Traktirov DS, Karpenko MN, and Fetissov SO
Publicado en:
Neuroimmunomodulation, Edición 30(1), 2023, Página(s) 15-27, ISSN 1021-7401
Editor:
S. Karger AG
DOI:
10.1159/000527872
Autores:
Lyudmila V. Gromova, Serguei O. Fetissov, Andrey A. Gruzdkov
Publicado en:
Nutrients, Edición 13/7, 2021, Página(s) 2474, ISSN 2072-6643
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13072474
Autores:
Noemi Di Nanni, Matteo Bersanelli, Luciano Milanesi, Ettore Mosca
Publicado en:
Frontiers in Genetics, Edición 11, 2020, ISSN 1664-8021
Editor:
Frontiers Media
DOI:
10.3389/fgene.2020.00106
Autores:
Chiappori F., Cupaioli F.A., Consiglio A., Di Nanni N., Mosca E., Licciulli V.F., Mezzelani A.
Publicado en:
Nutrients, Edición 14(7):1340, 2022 Mar 23, 2022, Página(s) 1-23, ISSN 2072-6643
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu14071340
Autores:
Zheng Y, Prince N, van Hattem C, Garssen J, Pardo PP, Kraneveld AD
Publicado en:
Molecular and Celullar Neuroscience, Edición Dec 30;124:103805, 2023, Página(s) 1-11, ISSN 1044-7431
Editor:
Academic Press
DOI:
10.1016/j.mcn.2022.103805
Autores:
Yuanpeng Zheng, Marie K Bek, Naika Z Prince, Lucia N Peralta Marzal, Johan Garssen, Paula Perez Pardo, Aletta D Kraneveld
Publicado en:
Frontiers in Neuroscience, Edición October, 2021, Página(s) 1401, ISSN 1662-453X
Editor:
Frontiers
DOI:
10.3389/fnins.2021.738220
Autores:
Athanasios Beopoulos, Manuel Gea, Alessio Fasano, François Iris
Publicado en:
Nutrients, 2021, ISSN 2072-6643
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu14010065
Autores:
Cupaioli FA, Mosca E, Magri C, Gennarelli M, Moscatelli M, Raggi ME, Landini M, Galluccio N, Villa L, Bonfanti A, Renieri A, Fallerini C, Minelli A, Marabotti A, Milanesi L, Fasano A, Mezzelani A
Publicado en:
Scientific Reports, Edición 10(1):7758, 2020 May 8, 2020, Página(s) 1-11, ISSN 2045-2322
Editor:
Nature Publishing Group
DOI:
10.1038/s41598-020-64679-w
Autores:
Nicol M., Lahaye E., El Mehdi M., do Rego J.-L., do Rego J.-C., Fetissov S.O.
Publicado en:
European Eating Disorders Review, 2023, ISSN 1099-0968
Editor:
Wiley
DOI:
10.1002/erv.3004
Autores:
Lucía N. Peralta-Marzal, Naika Prince, Djordje Bajic, Léa Roussin, Laurent Naudon, Sylvie Rabot,
Johan Garssen, Aletta D. Kraneveld and Paula Perez-Pardo
Publicado en:
International Journal of Molecular Sciences, Edición Volume 22, Edición 18, 2021, semimonthly, 2021, ISSN 1422-0067
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms221810052
Autores:
Yuanpeng Zheng, Tessa A. Verhoeff, Paula Perez Pardo, Johan Garssen and Aletta D. Kraneveld
Publicado en:
International Journal of Molecular Sciences, Edición volume 22, issue 1, 2021, semimonthly, 2021, ISSN 1422-0067
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms22010118
Autores:
Zheng, Y.; Prince, N.Z.; Peralta Marzal, L.N.; Ahmed, S.; Garssen, J.; Perez Pardo, P.; Kraneveld, A.D.
Publicado en:
Int J Mol Sci, Edición Sep 20;23(19):11013, 2022, Página(s) 1-17, ISSN 1422-0067
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms231911013
Autores:
Francesca Anna Cupaioli, Chiara Fallerini, Maria Antonietta Mencarelli, Valentina Perticaroli, Virginia Filippini, Francesca Mari, Alessandra Renieri, Alessandra Mezzelani
Publicado en:
Genes, Edición 12/10, 2021, Página(s) 1605, ISSN 2073-4425
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/genes12101605
Autores:
Ettore Mosca, Matteo Bersanelli, Tommaso Matteuzzi, Noemi Di Nanni, Gastone Castellani, Luciano Milanesi, Daniel Remondini
Publicado en:
Briefings in Bioinformatics, 2021, ISSN 1467-5463
Editor:
Oxford University Press
DOI:
10.1093/bib/bbab153
Autores:
Zolotarev V.A., Murovets V.O., Sepp A.L., Sozontov E.A., Lukina E.A., Khropycheva R.P., Pestereva N.S., Ivleva I.S., El Mehdi M., Lahaye E., Chartrel N., Fetissov S.O.
Publicado en:
International Journal of Molecular Sciences, Edición 24(13), 10590, 2023, ISSN 1422-0067
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms241310590
Autores:
Jacopo Troisi, Reija Autio, Thanos Beopoulos, Carmela Bravaccio, Federica Carraturo, Giulio Corrivetti, Stephen Cunningham, Samantha Devane, Daniele Fallin, Serguei Fetissov, Manuel Gea, Antonio Giorgi, François Iris, Lokesh Joshi, Sarah Kadzielski, Aletta Kraneveld, Himanshu Kumar, Christine Ladd-Acosta, Geraldine Leader, Arlene Mannion, Elise Maximin, Alessandra Mezzelani, Luciano Milanesi, Lau
Publicado en:
Brain Sciences, Edición 10/10, 2020, Página(s) 743, ISSN 2076-3425
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/brainsci10100743
Autores:
Martina Lombardi, Jacopo Troisi
Publicado en:
Nutrients, Edición 13/10, 2021, Página(s) 3492, ISSN 2072-6643
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13103492
Autores:
Cupaioli Francesca Anna, Corrivetti Giulio, Tamburro Ilaria, Fasano Alessio, Mezzelani
Alessandra
Publicado en:
International Journal of Humanities, Social Sciences and Education, Edición 7/9, 2020, ISSN 2349-0381
Editor:
ARC Publications Pvt Ltd
DOI:
10.20431/2349-0381.0709013
Autores:
Noemi Di Nanni, Matteo Bersanelli, Francesca Anna Cupaioli, Luciano Milanesi, Alessandra Mezzelani, Ettore Mosca
Publicado en:
International Journal of Molecular Sciences, Edición 20/13, 2019, Página(s) 3363, ISSN 1422-0067
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms20133363
Autores:
Léa Roussin, Naika Prince, Paula Perez-Pardo, Aletta D. Kraneveld, Sylvie Rabot, Laurent Naudon
Publicado en:
Microorganisms, Edición 8/9, 2020, Página(s) 1369, ISSN 2076-2607
Editor:
MDPI
DOI:
10.3390/microorganisms8091369
Autores:
Værøy H., Takhlidjt S., Cherifi Y., Lahaye E., Chartrel N., Fetissov S.O.
Publicado en:
Brain Sciences, Edición 13(2), 237, 2023, ISSN 2076-3425
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/brainsci13020237
Autores:
Værøy H., Lahaye E., Dubessy C., Benard M., Nicol M., Cherifi Y., Takhlidjt S., do Rego J.-L., do Rego J.-C., Chartrel N., Fetissov S.O.
Publicado en:
Discover Mental Health, Edición Oct 19;3(1):21, 2023, Página(s) Volume 3, article number 21, ISSN 2731-4383
Editor:
Springer
DOI:
10.1007/s44192-023-00048-z
Autores:
Beopoulos A, Géa M, Fasano A, Iris F
Publicado en:
Frontiers in neuroscience, Edición Nov 03 3;16:988735, 2022, Página(s) 1-24, ISSN 1662-453X
Editor:
Frontiers
DOI:
10.3389/fnins.2022.988735
Autores:
Noemi Di Nanni, Matteo Gnocchi, Marco Moscatelli, Luciano Milanesi, Ettore Mosca
Publicado en:
Bioinformatics, 2019, ISSN 1367-4803
Editor:
Oxford University Press
DOI:
10.1093/bioinformatics/btz652
Autores:
Oommen A, Cunningham S, Joshi L.
Publicado en:
Viruses, Edición Jan 8;13(1):82, 2021, Página(s) 1-15, ISSN 1999-4915
Editor:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/v13010082
Autores:
J. Troisi, M. Lombardi, SJK Symes, G. Scala, M. Delli Carri, SM Richards & GEMMA Consortium
Publicado en:
Bioinformatics and Computational Biology Conference, 2022
Editor:
F1000 Research
DOI:
10.7490/f1000research.1119307.1
Autores:
Mezzelani A, Cupaioli F.A.
Publicado en:
Brain Science, Edición 2023 Dec 7;13(12):1688, 2023, ISSN 2076-3425
Editor:
MDPI
DOI:
10.3390/brainsci13121688
Autores:
Brittany D. Needham, Mark D. Adame, Gloria Serena, Destanie R. Rose, Gregory M. Preston, Mary C. Conrad, A. Stewart Campbell, David H. Donabedian, Alessio Fasano, Paul Ashwood, Sarkis K. Mazmanian
Publicado en:
Journal Biological Psychiatry, Edición Volume 89, Edición 5, 2021, Página(s) 451-462, ISSN 0006-3223
Editor:
Elsevier
DOI:
10.1016/j.biopsych.2020.09.025
Autores:
Fetissov SO
Publicado en:
Microorganisms, Edición 11(3), 749, 2023, ISSN 2076-2607
Editor:
MDPI
DOI:
10.3390/microorganisms11030749
Autores:
Asbjornsdottir, B.; Snorradottir, H.; Andresdottir, E.; Fasano, A.; Lauth, B.; Gudmundsson, L.S.; Gottfredsson, M.; Halldorsson, T.I.; Birgisdottir, B.E.
Publicado en:
Nutrients, Edición Jul 3;12(7):1982, 2020, Página(s) 1-27, ISSN 2072-6643
Editor:
MDPI
DOI:
10.3390/nu12071982
Autores:
Patrone, D.; Alessio, N.; Antonucci, N.; Brigida, A.L.; Peluso, G.; Galderisi, U.; Siniscalco, D.
Publicado en:
Journal Methods Protoc, Edición Feb 24;5(2):20, 2022, Página(s) 1-6, ISSN 2409-9279
Editor:
MDPI
DOI:
10.3390/mps5020020
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