Risultati finali
Report on the outcomes of the participation of GEMMA at the 8th International Human Microbiome Congress in 2020 (Barcelona)
Final clinical protocolsStudy protocols to submit for the approbation to the ethical committee
Pre-clinical study 2 reportA report providing the results of the trial 2 to investigate if the ASD phenotype is dependent on microbiome-induced systemic immune activation, via adoptive splenocyte transfer studies
Theoretical qualitative models of ASD pathogenesis mechanismsA model specifically detail the mechanisms whereby alterations in gut microbiome may lead to persistent, low-grade feverless systemic inflammation and how this could then affect CNS metabolism and neuronal arborescence preferentially in male developing infants
Pre-clinical study ethical approval reportA study protocol to submit for the approbation to the ethical committee
Pre-clinical study 1 reportA report providing the results of the the trial 1 focus on exploring if the behavioural phenotype of ASD patients is transferrable to mice via faecal transplantation
Genome, epigenome and immune function interplay summary of hypothesisAn hypothesis regarding how the genome/metagenome interplay is responsible for the switch from immune tolerance to immune response to environmental stimuli (antigens) including dietary and microbial factors leading to neuroinflammation responsible of behavioural changes that characterize ASD and gut inflammation causing its GI co-morbidities
Updated state of the art reportReport providing a brief relation about the state of the art in the ASD biomarker and therapy
Microbiome, metabolome and immune function interplay summary of hypothesisAn hypothesis regarding how the gut bacterial dysbiosis leads to epigenetic modifications, changes in metabolic profiles, increased gut permeability, increased antigen trafficking and, ultimately to altered immune responses to promote disease in a subset of individuals at-risk of ASD
Pre-clinical study 3/1 reportA first report providing the results of trial 3 to establish whether correction of dysbiosis by pre/pro/symbiotic intervention prevents and/or treats increased the impaired gut permeability, changes in metabolic profile, modification of the immune response, and, ultimately, the onset of ASD behavioural symptoms in humanized murine models of ASD (mice transplanted with faecal bacterial content of ASD patient donor sample
An algorithms able to associate various biomarker levels observed in infants with ASD and GI symptoms. This alghorithm will use advanced statistical analysis methods such as sparse canonical correlation (a linear correlation method) combined with random forests (a non-linear correlation method) to detect these associations between the omics data.
Second release of the multi-omics platform (observational trials)An analysis of the fitting between the correlations put forward by the multi-omics analyses and the biological outcome of the interventional part of the observational study
OmnomicsNGS v2 releaseA new relase of the software OmnomicsNGS including a tool for dynamic variant analysis and interpretation
GEMMA participation on H2020 open data pilot
Project website: project description, public deliverables, scientific news, other
Pubblicazioni
Autori:
Oommen AM, Cunningham S, O'Súilleabháin PS, Hughes BM, Joshi L
Pubblicato in:
Scientific Reports, Numero (2021) 11:9645, 2021, ISSN 2045-2322
Editore:
Nature Publishing Group
DOI:
10.1038/s41598-021-89040-7
Autori:
Muruzheva ZM, Egorov DS, Absalyamova MT, Traktirov DS, Karpenko MN, and Fetissov SO
Pubblicato in:
Neuroimmunomodulation, Numero 30(1), 2023, Pagina/e 15-27, ISSN 1021-7401
Editore:
S. Karger AG
DOI:
10.1159/000527872
Autori:
Lyudmila V. Gromova, Serguei O. Fetissov, Andrey A. Gruzdkov
Pubblicato in:
Nutrients, Numero 13/7, 2021, Pagina/e 2474, ISSN 2072-6643
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13072474
Autori:
Noemi Di Nanni, Matteo Bersanelli, Luciano Milanesi, Ettore Mosca
Pubblicato in:
Frontiers in Genetics, Numero 11, 2020, ISSN 1664-8021
Editore:
Frontiers Media
DOI:
10.3389/fgene.2020.00106
Autori:
Chiappori F., Cupaioli F.A., Consiglio A., Di Nanni N., Mosca E., Licciulli V.F., Mezzelani A.
Pubblicato in:
Nutrients, Numero 14(7):1340, 2022 Mar 23, 2022, Pagina/e 1-23, ISSN 2072-6643
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu14071340
Autori:
Zheng Y, Prince N, van Hattem C, Garssen J, Pardo PP, Kraneveld AD
Pubblicato in:
Molecular and Celullar Neuroscience, Numero Dec 30;124:103805, 2023, Pagina/e 1-11, ISSN 1044-7431
Editore:
Academic Press
DOI:
10.1016/j.mcn.2022.103805
Autori:
Yuanpeng Zheng, Marie K Bek, Naika Z Prince, Lucia N Peralta Marzal, Johan Garssen, Paula Perez Pardo, Aletta D Kraneveld
Pubblicato in:
Frontiers in Neuroscience, Numero October, 2021, Pagina/e 1401, ISSN 1662-453X
Editore:
Frontiers
DOI:
10.3389/fnins.2021.738220
Autori:
Athanasios Beopoulos, Manuel Gea, Alessio Fasano, François Iris
Pubblicato in:
Nutrients, 2021, ISSN 2072-6643
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu14010065
Autori:
Cupaioli FA, Mosca E, Magri C, Gennarelli M, Moscatelli M, Raggi ME, Landini M, Galluccio N, Villa L, Bonfanti A, Renieri A, Fallerini C, Minelli A, Marabotti A, Milanesi L, Fasano A, Mezzelani A
Pubblicato in:
Scientific Reports, Numero 10(1):7758, 2020 May 8, 2020, Pagina/e 1-11, ISSN 2045-2322
Editore:
Nature Publishing Group
DOI:
10.1038/s41598-020-64679-w
Autori:
Nicol M., Lahaye E., El Mehdi M., do Rego J.-L., do Rego J.-C., Fetissov S.O.
Pubblicato in:
European Eating Disorders Review, 2023, ISSN 1099-0968
Editore:
Wiley
DOI:
10.1002/erv.3004
Autori:
Lucía N. Peralta-Marzal, Naika Prince, Djordje Bajic, Léa Roussin, Laurent Naudon, Sylvie Rabot,
Johan Garssen, Aletta D. Kraneveld and Paula Perez-Pardo
Pubblicato in:
International Journal of Molecular Sciences, Numero Volume 22, Numero 18, 2021, semimonthly, 2021, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms221810052
Autori:
Yuanpeng Zheng, Tessa A. Verhoeff, Paula Perez Pardo, Johan Garssen and Aletta D. Kraneveld
Pubblicato in:
International Journal of Molecular Sciences, Numero volume 22, issue 1, 2021, semimonthly, 2021, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms22010118
Autori:
Zheng, Y.; Prince, N.Z.; Peralta Marzal, L.N.; Ahmed, S.; Garssen, J.; Perez Pardo, P.; Kraneveld, A.D.
Pubblicato in:
Int J Mol Sci, Numero Sep 20;23(19):11013, 2022, Pagina/e 1-17, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms231911013
Autori:
Francesca Anna Cupaioli, Chiara Fallerini, Maria Antonietta Mencarelli, Valentina Perticaroli, Virginia Filippini, Francesca Mari, Alessandra Renieri, Alessandra Mezzelani
Pubblicato in:
Genes, Numero 12/10, 2021, Pagina/e 1605, ISSN 2073-4425
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/genes12101605
Autori:
Ettore Mosca, Matteo Bersanelli, Tommaso Matteuzzi, Noemi Di Nanni, Gastone Castellani, Luciano Milanesi, Daniel Remondini
Pubblicato in:
Briefings in Bioinformatics, 2021, ISSN 1467-5463
Editore:
Oxford University Press
DOI:
10.1093/bib/bbab153
Autori:
Zolotarev V.A., Murovets V.O., Sepp A.L., Sozontov E.A., Lukina E.A., Khropycheva R.P., Pestereva N.S., Ivleva I.S., El Mehdi M., Lahaye E., Chartrel N., Fetissov S.O.
Pubblicato in:
International Journal of Molecular Sciences, Numero 24(13), 10590, 2023, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms241310590
Autori:
Jacopo Troisi, Reija Autio, Thanos Beopoulos, Carmela Bravaccio, Federica Carraturo, Giulio Corrivetti, Stephen Cunningham, Samantha Devane, Daniele Fallin, Serguei Fetissov, Manuel Gea, Antonio Giorgi, François Iris, Lokesh Joshi, Sarah Kadzielski, Aletta Kraneveld, Himanshu Kumar, Christine Ladd-Acosta, Geraldine Leader, Arlene Mannion, Elise Maximin, Alessandra Mezzelani, Luciano Milanesi, Lau
Pubblicato in:
Brain Sciences, Numero 10/10, 2020, Pagina/e 743, ISSN 2076-3425
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/brainsci10100743
Autori:
Martina Lombardi, Jacopo Troisi
Pubblicato in:
Nutrients, Numero 13/10, 2021, Pagina/e 3492, ISSN 2072-6643
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/nu13103492
Autori:
Cupaioli Francesca Anna, Corrivetti Giulio, Tamburro Ilaria, Fasano Alessio, Mezzelani
Alessandra
Pubblicato in:
International Journal of Humanities, Social Sciences and Education, Numero 7/9, 2020, ISSN 2349-0381
Editore:
ARC Publications Pvt Ltd
DOI:
10.20431/2349-0381.0709013
Autori:
Noemi Di Nanni, Matteo Bersanelli, Francesca Anna Cupaioli, Luciano Milanesi, Alessandra Mezzelani, Ettore Mosca
Pubblicato in:
International Journal of Molecular Sciences, Numero 20/13, 2019, Pagina/e 3363, ISSN 1422-0067
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms20133363
Autori:
Léa Roussin, Naika Prince, Paula Perez-Pardo, Aletta D. Kraneveld, Sylvie Rabot, Laurent Naudon
Pubblicato in:
Microorganisms, Numero 8/9, 2020, Pagina/e 1369, ISSN 2076-2607
Editore:
MDPI
DOI:
10.3390/microorganisms8091369
Autori:
Værøy H., Takhlidjt S., Cherifi Y., Lahaye E., Chartrel N., Fetissov S.O.
Pubblicato in:
Brain Sciences, Numero 13(2), 237, 2023, ISSN 2076-3425
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/brainsci13020237
Autori:
Værøy H., Lahaye E., Dubessy C., Benard M., Nicol M., Cherifi Y., Takhlidjt S., do Rego J.-L., do Rego J.-C., Chartrel N., Fetissov S.O.
Pubblicato in:
Discover Mental Health, Numero Oct 19;3(1):21, 2023, Pagina/e Volume 3, article number 21, ISSN 2731-4383
Editore:
Springer
DOI:
10.1007/s44192-023-00048-z
Autori:
Beopoulos A, Géa M, Fasano A, Iris F
Pubblicato in:
Frontiers in neuroscience, Numero Nov 03 3;16:988735, 2022, Pagina/e 1-24, ISSN 1662-453X
Editore:
Frontiers
DOI:
10.3389/fnins.2022.988735
Autori:
Noemi Di Nanni, Matteo Gnocchi, Marco Moscatelli, Luciano Milanesi, Ettore Mosca
Pubblicato in:
Bioinformatics, 2019, ISSN 1367-4803
Editore:
Oxford University Press
DOI:
10.1093/bioinformatics/btz652
Autori:
Oommen A, Cunningham S, Joshi L.
Pubblicato in:
Viruses, Numero Jan 8;13(1):82, 2021, Pagina/e 1-15, ISSN 1999-4915
Editore:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/v13010082
Autori:
J. Troisi, M. Lombardi, SJK Symes, G. Scala, M. Delli Carri, SM Richards & GEMMA Consortium
Pubblicato in:
Bioinformatics and Computational Biology Conference, 2022
Editore:
F1000 Research
DOI:
10.7490/f1000research.1119307.1
Autori:
Mezzelani A, Cupaioli F.A.
Pubblicato in:
Brain Science, Numero 2023 Dec 7;13(12):1688, 2023, ISSN 2076-3425
Editore:
MDPI
DOI:
10.3390/brainsci13121688
Autori:
Brittany D. Needham, Mark D. Adame, Gloria Serena, Destanie R. Rose, Gregory M. Preston, Mary C. Conrad, A. Stewart Campbell, David H. Donabedian, Alessio Fasano, Paul Ashwood, Sarkis K. Mazmanian
Pubblicato in:
Journal Biological Psychiatry, Numero Volume 89, Numero 5, 2021, Pagina/e 451-462, ISSN 0006-3223
Editore:
Elsevier
DOI:
10.1016/j.biopsych.2020.09.025
Autori:
Fetissov SO
Pubblicato in:
Microorganisms, Numero 11(3), 749, 2023, ISSN 2076-2607
Editore:
MDPI
DOI:
10.3390/microorganisms11030749
Autori:
Asbjornsdottir, B.; Snorradottir, H.; Andresdottir, E.; Fasano, A.; Lauth, B.; Gudmundsson, L.S.; Gottfredsson, M.; Halldorsson, T.I.; Birgisdottir, B.E.
Pubblicato in:
Nutrients, Numero Jul 3;12(7):1982, 2020, Pagina/e 1-27, ISSN 2072-6643
Editore:
MDPI
DOI:
10.3390/nu12071982
Autori:
Patrone, D.; Alessio, N.; Antonucci, N.; Brigida, A.L.; Peluso, G.; Galderisi, U.; Siniscalco, D.
Pubblicato in:
Journal Methods Protoc, Numero Feb 24;5(2):20, 2022, Pagina/e 1-6, ISSN 2409-9279
Editore:
MDPI
DOI:
10.3390/mps5020020
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