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Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

Objective

The ATHENA consortium aims to mobilise the scientific progress made in recent years to close critical gaps left open in test methods for thyroid hormone axis disrupting-chemicals. We will develop new methods for incorporation into existing OECD test guidelines that can capture the consequences of maternal thyroid hormone deficiency on the developing brain, due to disruption of delivery of thyroid hormones to the foetus. To make this possible, we will establish new endpoints for identifying down-stream effects on the developing brain in foetal and post-natal life. We will provide new test methods for chemicals that interfere with the delivery of thyroid hormones to the foetus and the adult brain across physiological barriers such as the placenta, the blood brain barrier and the blood brain cerebrospinal fluid barrier. We will also develop QSARs for the screening of large compound libraries and methods for capturing disruption of the local supply of thyroid hormone by inhibition of deiodinases, dehalogenases and cell membrane transporters. Based on the construction of AOP networks for adverse neurodevelopmental effects, we will deliver a comprehensive testing strategy that can protect from chemicals that have the potential to harm brain development in foetal life and adulthood by disrupting the availability of thyroid hormones. Finally, ATHENA will conceive strategies for the international harmonisation of screening, testing and hazard identification for thyroid hormone axis disrupting chemicals. ATHENA comprises world-leading endocrinologists, experts in endocrine disruption and experts in modelling brain function ex vivo who collectively will deliver a step change in thyroid disruptor testing.

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
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Coordinator

BRUNEL UNIVERSITY LONDON
Address
Kingston Lane
UB8 3PH Uxbridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 052 313,75

Participants (9)

DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 1 071 857,50
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 997 330
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 652 917,50
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
STICHTING VU
Netherlands
EU contribution
€ 698 130
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 778 372,50
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
OREBRO UNIVERSITY
Sweden
EU contribution
€ 157 255
Address
Fakultetsgatan 1
70182 Orebro
Activity type
Higher or Secondary Education Establishments
WATCHFROG
France
EU contribution
€ 576 505
Address
4 Rue Pierre Fontaine
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KARLSTADS UNIVERSITET
Sweden
EU contribution
€ 50 537,50
Address
Universitetsgatan 2
651 88 Karlstad
Activity type
Higher or Secondary Education Establishments
RISE RESEARCH INSTITUTES OF SWEDEN AB
Sweden
EU contribution
€ 530 245
Address
Brinellgatan 4
501 15 Boras
Activity type
Research Organisations