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Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

Objective

The ATHENA consortium aims to mobilise the scientific progress made in recent years to close critical gaps left open in test methods for thyroid hormone axis disrupting-chemicals. We will develop new methods for incorporation into existing OECD test guidelines that can capture the consequences of maternal thyroid hormone deficiency on the developing brain, due to disruption of delivery of thyroid hormones to the foetus. To make this possible, we will establish new endpoints for identifying down-stream effects on the developing brain in foetal and post-natal life. We will provide new test methods for chemicals that interfere with the delivery of thyroid hormones to the foetus and the adult brain across physiological barriers such as the placenta, the blood brain barrier and the blood brain cerebrospinal fluid barrier. We will also develop QSARs for the screening of large compound libraries and methods for capturing disruption of the local supply of thyroid hormone by inhibition of deiodinases, dehalogenases and cell membrane transporters. Based on the construction of AOP networks for adverse neurodevelopmental effects, we will deliver a comprehensive testing strategy that can protect from chemicals that have the potential to harm brain development in foetal life and adulthood by disrupting the availability of thyroid hormones. Finally, ATHENA will conceive strategies for the international harmonisation of screening, testing and hazard identification for thyroid hormone axis disrupting chemicals. ATHENA comprises world-leading endocrinologists, experts in endocrine disruption and experts in modelling brain function ex vivo who collectively will deliver a step change in thyroid disruptor testing.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2018-Single-Stage-RTD

Coordinator

BRUNEL UNIVERSITY LONDON
Net EU contribution
€ 1 052 313,75
Address
Kingston Lane
UB8 3PH Uxbridge
United Kingdom

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Region
London Outer London — West and North West Harrow and Hillingdon
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (10)

DANMARKS TEKNISKE UNIVERSITET
Denmark
Net EU contribution
€ 1 071 857,50
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 997 330,00
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 498 610,21
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

MUSEUM NATIONAL D'HISTOIRE NATURELLE
France
Net EU contribution
€ 154 307,29
Address
Rue Cuvier 57
75005 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STICHTING VU
Netherlands
Net EU contribution
€ 698 130,00
Address
De Boelelaan 1105
1081 HV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 778 372,50
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
OREBRO UNIVERSITY
Sweden
Net EU contribution
€ 157 255,00
Address
Fakultetsgatan 1
70182 Orebro

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Region
Östra Sverige Östra Mellansverige Örebro län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
WATCHFROG
France
Net EU contribution
€ 576 505,00
Address
4 Rue Pierre Fontaine
91000 Evry

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
KARLSTADS UNIVERSITET
Sweden
Net EU contribution
€ 50 537,50
Address
Universitetsgatan 2
651 88 Karlstad

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Region
Norra Sverige Norra Mellansverige Värmlands län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
RISE RESEARCH INSTITUTES OF SWEDEN AB
Sweden
Net EU contribution
€ 530 245,00
Address
Brinellgatan 4
501 15 Boras

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Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Research Organisations
Non-EU contribution
€ 0,00