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Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

Ziel

The ATHENA consortium aims to mobilise the scientific progress made in recent years to close critical gaps left open in test methods for thyroid hormone axis disrupting-chemicals. We will develop new methods for incorporation into existing OECD test guidelines that can capture the consequences of maternal thyroid hormone deficiency on the developing brain, due to disruption of delivery of thyroid hormones to the foetus. To make this possible, we will establish new endpoints for identifying down-stream effects on the developing brain in foetal and post-natal life. We will provide new test methods for chemicals that interfere with the delivery of thyroid hormones to the foetus and the adult brain across physiological barriers such as the placenta, the blood brain barrier and the blood brain cerebrospinal fluid barrier. We will also develop QSARs for the screening of large compound libraries and methods for capturing disruption of the local supply of thyroid hormone by inhibition of deiodinases, dehalogenases and cell membrane transporters. Based on the construction of AOP networks for adverse neurodevelopmental effects, we will deliver a comprehensive testing strategy that can protect from chemicals that have the potential to harm brain development in foetal life and adulthood by disrupting the availability of thyroid hormones. Finally, ATHENA will conceive strategies for the international harmonisation of screening, testing and hazard identification for thyroid hormone axis disrupting chemicals. ATHENA comprises world-leading endocrinologists, experts in endocrine disruption and experts in modelling brain function ex vivo who collectively will deliver a step change in thyroid disruptor testing.

Aufforderung zur Vorschlagseinreichung

H2020-SC1-2018-Single-Stage-RTD
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BRUNEL UNIVERSITY LONDON
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United Kingdom
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DANMARKS TEKNISKE UNIVERSITET
Dänemark
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Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
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CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Deutschland
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Chariteplatz 1
10117 Berlin
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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Frankreich
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€ 652 917,50
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Rue Michel Ange 3
75794 Paris
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STICHTING VU
Niederlande
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€ 698 130
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De Boelelaan 1105
1081 HV Amsterdam
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ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Niederlande
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€ 778 372,50
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Dr Molewaterplein 40
3015 GD Rotterdam
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OREBRO UNIVERSITY
Schweden
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€ 157 255
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Fakultetsgatan 1
70182 Orebro
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WATCHFROG
Frankreich
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Rue Pierre Fontaine 4
91000 Evry
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KARLSTADS UNIVERSITET
Schweden
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Universitetsgatan 2
651 88 Karlstad
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RISE RESEARCH INSTITUTES OF SWEDEN AB
Schweden
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Brinellgatan 4
501 15 Boras
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