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Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

Deliverables

Policy briefing no 2 to the European Commission and JRC

Policy briefing no 2 to the European Commission and JRC

Risk assessment procedure

Risk assessment procedure

Concept for interaction with other H2020 projects on EDC test method development

Concept for interaction with other H2020 projects on EDC test method development This will detail a series of activities with the other 7 projects funded under this call

Policy briefing no 1 to the European Commission and JRC

Policy briefing no 1 to the European Commission and JRC: These policy briefing will summarise relevant work in ATHENA, together with policy implications

Preliminary plan for exploitation and dissemination

Release of a preliminary plan for exploitation and dissemination

Data on associations of exposure to major EDC subgroups with maternal thyroid function during pregnancy

Provide data on the association of exposure to major EDCs subgroups with maternal thyroid function during pregnancy (month18) (ERASMUS): We will leverage epidemiological studies with information on EDC exposures and T4 levels in pregnancy to provide criteria for test compound selection in the subsequent WP

Reporting templates and project handbook

Reporting templates and project handbook: we will create reporting templates and a project handbook, to be delivered to all partners to ease the reporting on finances and deliverables

Data Management plan

Submission of a first version of a Data Management Plan (DMP) at month 6 of the project. The DMP will be updated over the course of the project whenever significant changes arise, such as (but not limited to): - new data - changes in consortium policies (e.g. new innovation potential, decision to file for a patent) - changes in consortium composition and external factors (e.g. new consortium members joining or old members leaving).

Project website

Project website The site will link to a portal of all projects funded under this call and will detail the work programme and partners in ATHENA

Publications

Association of urinary bisphenols and triclosan with thyroid function during early pregnancy

Author(s): Arash Derakhshan, Huan Shu, Robin P. Peeters, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Carl-Gustaf Bornehag, Tim I.M. Korevaar
Published in: Environment International, 133, 2019, Page(s) 105123, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2019.105123

Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.

Author(s): Ramhøj L, Svingen T, Frädrich C, Rijntjes E, Wirth EK, Pedersen K, Köhrle J, Axelstad M
Published in: Toxicology Letters, 2021, ISSN 0378-4274
Publisher: Elsevier BV
DOI: 10.1016/j.toxlet.2021.10.010

Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.

Author(s): Delfosse V, Huet T, Harrus D, Granell M, Bourguet M, Gardia-Parège C, Chiavarina B, Grimaldi M, Le Mével S, Blanc P, Huang D, Gruszczyk J, Demeneix B, Cianférani S, Fini JB, Balaguer P, Bourguet W.
Published in: Proceedings of the National Academy of Sciences, 118, 2020, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2020551118

Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

Author(s): Stephan Couderq, Michelle Leemans, Jean-Baptiste Fini
Published in: Molecular and Cellular Endocrinology, 508, 2020, Page(s) 110779, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2020.110779

Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project

Author(s): Andreas Kortenkamp, Marta Axelstad, Asma H. Baig, Åke Bergman, Carl-Gustaf Bornehag, Peter Cenijn, Sofie Christiansen, Barbara Demeneix, Arash Derakhshan, Jean-Baptiste Fini, Caroline Frädrich, Timo Hamers, Lina Hellwig, Josef Köhrle, Tim I.M. Korevaar, Johan Lindberg, Olwenn Martin, Marcel E. Meima, Philipp Mergenthaler, Nikolai Nikolov, David Du Pasquier, Robin P. Peeters, Bjorn Platzack, Lou
Published in: International Journal of Molecular Sciences, 21/9, 2020, Page(s) 3123, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093123

Association of phthalate exposure with thyroid function during pregnancy

Author(s): Arash Derakhshan, Huan Shu, Maarten A.C. Broeren, Christian H. Lindh, Robin P. Peeters, Andreas Kortenkamp, Barbara Demeneix, Carl-Gustaf Bornehag, Tim I.M. Korevaar.
Published in: Environment International, 157, 2021, Page(s) 106795, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106795

Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase.

Author(s): Ramhøj L, Frädrich C, Svingen T, Scholze M, Wirth EK, Rijntjes E, Köhrle J, Kortenkamp A, Axelstad M.
Published in: Environmental Pollution, 2021, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2021.117135

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Author(s): Michelle Leemans, Stephan Couderq, Barbara Demeneix, Jean-Baptiste Fini
Published in: Frontiers in Endocrinology, 10, 2019, ISSN 1664-2392
Publisher: Frontiers
DOI: 10.3389/fendo.2019.00743

Association of urinary bisphenols during pregnancy with maternal, cord blood and childhood thyroid function

Author(s): Arash Derakhshan, Elise M Philips, Akhgar Ghassabian, Susana Santos, Alexandros G Asimakopoulos, Kurunthachalam Kannan, Andreas Kortenkamp, Vincent WV Jaddoe, Leonardo Trasande, Robin P Peeters, Tim IM Korevaar
Published in: Environment International, 146, 2021, Page(s) 106160, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106160