Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmerica

Project Information

DIABFRAIL-LATAM

Grant agreement ID: 825546

DOI

10.3030/825546

Project closed

EC signature date 3 December 2018

Start date 1 January 2019

End date 31 December 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 3 991 925,00

EU contribution

€ 3 891 925,00

Coordinated by

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (4)

Production and validation of training material
Project Webpage & and Visual identity report
Training of study personnel
Report Advocacy and training sessions

Documents, reports (16)

Scaling-up strategy
Feasibility Questionnaires

Feasibility Questionnaires: Designed and sent to the sites to explore the characteristics of the sites involved in the study (number of physicians, primary care or hospital, population covered by the trial site, number of nurses, administrative resources, type of population (economical resources, dispersion, urban/rural)

Final clinical trial report
Report about the scaling up process
Interim monitoring Dissemination, communication & exploitation report
statistical and health economic plan
Progress Report

Progress Report Its aims to make an assessment of the level of compliance of the project implementation with respect to the plan foreseen for its execution including quality assurance deliverables and milestones and use of resources

Preparation of a risk mitigation plan
Risk plan
Preparation of a monitoring plan
Economical resources questionnaire
Final Dissemination, communication & exploitation report
Appointment of the standardisation team
Midterm recruitment report
Final statistical and health economic analysis report
Initial PEDR

Other (3)

Final database available to be uploaded to the Extended Open Research Data Pilot
Project Handbook: Guidelines for partners to consult management procedures
Devices (platform and all regarding devices)

The adherence to the study will be assess through two different methods: Diaries (to self-report the participant or carer the adherence to the study) and Kronowise device (to evaluate the adherence to the programme and physical activity in intervention group)

Demonstrators, pilots, prototypes (4)

Refined plan for the Exploitation and Dissemination of the project results
Clinical Trial Methodology including training manuals, e learning package
First study subject approvals package: protocol approved, registration number in a WHO and Clinicaltrials.gov and ERB and other Regulatory Authorities (if applicable) approval prior to enrolment the first participant

First study subject approvals package protocol approved registration number in a WHO and Clinicaltrialsgov and ERB and other Regulatory Authorities if applicable approval prior to enrolment the first participant

Training and Educational Workshop

Publications

Peer reviewed articles (16)

Residual effects of 12 weeks of power‐oriented resistance training plus high‐intensity interval training on muscle dysfunction, systemic oxidative damage, and antioxidant capacity after 10 months of training cessation in older people with <scp>COPD</scp>

Author(s): Ivan Baltasar‐Fernandez, Jose Losa‐Reyna, Aitor Carretero, Carlos Rodriguez‐Lopez, Ana Alfaro‐Acha, Amelia Guadalupe‐Grau, Ignacio Ara, Luis M. Alegre, Mari Carmen Gomez‐Cabrera, Francisco J. García‐García, Julian Alcazar
Published in: Scandinavian Journal of Medicine &amp; Science in Sports, Issue 33, 2023, Page(s) 1661-1676, ISSN 0905-7188
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/sms.14428

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Author(s): Luis Filipe Costa-Machado, Esther Garcia-Dominguez, Rebecca L. McIntyre, Jose Luis Lopez-Aceituno, Álvaro Ballesteros-Gonzalez, Andrea Tapia-Gonzalez, David Fabregat-Safont, Tobias Eisenberg, Jesús Gomez, Adrian Plaza, Aranzazu Sierra-Ramirez, Manuel Perez, David Villanueva-Bermejo, Tiziana Fornari, María Isabel Loza, Gonzalo Herradon, Sebastian J. Hofer, Christoph Magnes, Frank Madeo, Janet S.
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38410-y

Free radicals in Alzheimer's disease: From pathophysiology to clinical trial results

Author(s): José Viña, Consuelo Borrás, Cristina Mas-Bargues
Published in: Free Radical Biology and Medicine, Issue 225, 2025, Page(s) 296-301, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.09.051

Phenotypic upregulation of hexocylceramides and ether‐linked phosphocholines as markers of human extreme longevity

Author(s): Anna Fernàndez‐Bernal, Joaquim Sol, José Daniel Galo‐Licona, Natàlia Mota‐Martorell, Cristina Mas‐Bargues, Ángel Belenguer‐Varea, Èlia Obis, José Viña, Consuelo Borrás, Mariona Jové, Reinald Pamplona
Published in: Aging Cell, 2024, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.14429

Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study

Author(s): Mariana Nepomuceno, Paloma Monllor, Maria Jose Cardells, Artemis Ftara, Maria Magallon, Francisco Dasí, Mari Carmen Badia, Jose Viña, Ana Lloret
Published in: Free Radical Biology and Medicine, Issue 215, 2024, Page(s) 56-63, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.02.021

Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease

Author(s): María-Ángeles Bonmatí-Carrión, Maria-Angeles Rol
Published in: Antioxidants, Issue 13, 2024, Page(s) 34, ISSN 2076-3921
Publisher: Antioxidants
DOI: 10.3390/antiox13010034

The repeated bout effect evokes the training-induced skeletal muscle cellular memory

Author(s): Miguel Calvo-Rubio, Esther Garcia-Dominguez, Eva Tamayo-Torres, Silvana Soto-Rodríguez, Gloria Olaso-Gonzalez, Luigi Ferrucci, Rafael de Cabo, Maria Carmen Gómez-Cabrera
Published in: Free Radical Biology and Medicine, Issue 225, 2025, Page(s) 247-254, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.09.047

Diet and exercise in frailty and sarcopenia. Molecular aspects

Author(s): Fernando Millan-Domingo, Esther Garcia-Dominguez, Juan Gambini, Gloria Olaso-Gonzalez, Jose Viña, Maria Carmen Gomez-Cabrera
Published in: Molecular Aspects of Medicine, Issue 100, 2024, Page(s) 101322, ISSN 0098-2997
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101322

Living at the Wrong Time: Effects of Unmatching Official Time in Portugal and Western Spain

Author(s): Bonmatí-Carrión MÁ, Casado-Ramirez E, Moreno-Casbas MT, Campos M, ModulEN Consortium, Madrid JA, Rol MA.
Published in: Biology (Basel), Issue 11(8), 2022, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology11081130.

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

Author(s): Mikel Izquierdo, Philipe de Souto Barreto, Hidenori Arai, Heike A. Bischoff-Ferrari, Eduardo L. Cadore, Matteo Cesari, Liang-Kung Chen, Paul M. Coen, Kerry S. Courneya, Gustavo Duque, Luigi Ferrucci, Roger A. Fielding, Antonio García-Hermoso, Luis Miguel Gutiérrez-Robledo, Stephen D.R. Harridge, Ben Kirk, Stephen Kritchevsky, Francesco Landi, Norman Lazarus, Teresa Liu-Ambrose, Emanuele Marzetti
Published in: The Journal of nutrition, health and aging, Issue 29, 2025, Page(s) 100401, ISSN 1279-7707
Publisher: SERDI Publisher
DOI: 10.1016/j.jnha.2024.100401

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.

Author(s): Sanz-Ros J, Romero-García N, Mas-Bargues C, Monleón D, Gordevicius J, Brooke RT, Dromant M, Díaz A, Derevyanko A, Guío-Carrión A, Román-Domínguez A, Inglés M, Blasco MA, Horvath S, Viña J, Borrás C.
Published in: Sci Adv., Issue Oct 2022, 2022, Page(s) eabq2226, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abq2226

Phase Response Curve to Light under Ambulatory Conditions: A Pilot Study for Potential Application to Daylight Saving Time Transitions

Author(s): Raquel Arguelles-Prieto, Juan Antonio Madrid , Maria Angeles Rol, María Ángeles Bonmatí-Carrión
Published in: Biology (Basel), Issue 11(11), 2022, ISSN 2079-7737
Publisher: MDPI

Multimodal cell atlas of the ageing human skeletal muscle

Author(s): Yiwei Lai, Ignacio Ramírez-Pardo, Joan Isern, Juan An, Eusebio Perdiguero, Antonio L. Serrano, Jinxiu Li, Esther García-Domínguez, Jessica Segalés, Pengcheng Guo, Vera Lukesova, Eva Andrés, Jing Zuo, Yue Yuan, Chuanyu Liu, José Viña, Julio Doménech-Fernández, Mari Carmen Gómez-Cabrera, Yancheng Song, Longqi Liu, Xun Xu, Pura Muñoz-Cánoves, Miguel A. Esteban
Published in: Nature, Issue 629, 2024, Page(s) 154-164, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07348-6

Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer’s disease

Author(s): Angela G. Correas, Gloria Olaso-Gonzalez, Marta Roca, Mari Carmen Blanco-Gandía, Carla Nascimento, Agustin Lahoz, Marta Rodriguez-Arias, José Miñarro, Mari Carmen Gomez-Cabrera, José Viña
Published in: Redox Biology, Issue 75, 2024, Page(s) 103242, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2024.103242

Genistein, A Phytoestrogen, Delays the Transition to Dementia in Prodromal Alzheimer’s Disease Patients

Author(s): José Viña, Consuelo Borrás, Cristina Mas-Bargues
Published in: Journal of Alzheimer's Disease, Issue 101, 2024, Page(s) S275-S283, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-240308

Molecular mechanisms of cancer cachexia. Role of exercise training

Author(s): Eva Tamayo-Torres, Amanda Garrido, Rafael de Cabo, Julián Carretero, María Carmen Gómez-Cabrera
Published in: Molecular Aspects of Medicine, Issue 99, 2024, Page(s) 101293, ISSN 0098-2997
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101293

Non-peer reviewed articles (2)

Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice

Author(s): Bernier M, Enamorado IN, Gómez-Cabrera MC, Calvo-Rubio M, González-Reyes JA, Price NL, Cortés-Rodríguez AB, Rodríguez-Aguilera JC, Rodríguez-López S, Mitchell SJ, Murt KN, Kalafut K, Williams KM, Ward CW, Stains JP, Brea-Calvo G, Villalba JM, Cortassa S, Aon MA, de Cabo R.
Published in: Aging, Issue Jun 27;8(1):8, 2022, Page(s) 8, ISSN 1945-4589
Publisher: NPJ

Glucosamine Supplementation Improves Physical Performance in Trained Mice.

Author(s): DE LA Rosa A, Olaso-Gonzalez G, Garcia-Dominguez E, Mastaloudis A, Hester SN, Wood SM, Gomez-Cabrera MC, Viña J.
Published in: Med Sci Sports Exerc., Issue Mar 1;54(3):466-474., 2022, Page(s) 466-474, ISSN 1530-0315
Publisher: wolters kluwer
DOI: 10.1249/mss.0000000000002821

Other (4)

Real-Life Outcomes of a Multicomponent Exercise Intervention in Community-Dwelling Frail Older Adults and Its Association with Nutritional-Related Factors

Author(s): Millan-Domingo F, Tarazona-Santabalbina FJ, Carretero A, Olaso-Gonzalez G, Viña J, Gomez-Cabrera MC.
Published in: Nutrients, Issue Dec 2022, 2022, Page(s) 5147, ISSN 2072-6643
Publisher: MDPI
DOI: 10.1038/s41514-022-00089-8

Test de los cuatro tiempos. Intelectual property registration. NÚMERO DE ASIENTO REGISTRAL 08 / 2022 / 508

Author(s): Rol MA, Gonzalez-Romero P, Madrid JA, Campos M, Martínez-Madrid MJ, Rodriguez-Morilla B.
Published in: 2022
Publisher: -

Glucose 6-P Dehydrogenase-An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise.

Author(s): García-Domínguez E, Carretero A, Viña-Almunia A, Domenech-Fernandez J, Olaso-Gonzalez G, Viña J, Gomez-Cabrera MC.
Published in: Cells, Issue Sep 28;11(19):3041, 2022, Page(s) 3041, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11193041

Que nada te quite el sueño

Author(s): Bonmatí Carrión MA
Published in: Editorial Crítica, Issue 2023, 2023, ISBN 978-84-9199-497-8
Publisher: Editorial Crítica

Conference proceedings (1)

El sueño el cuarto pilar de la salud

Author(s): Madrid JA, Tomas-Loba A, Rol MA.
Published in: dossies revista SEBBM, Issue 44896, 2022, Page(s) 8
Publisher: SEBBM

Monographic books (1)

Cronobiología. Una guía para descubrir tu reloj biológico.

Author(s): Madrid JA
Published in: Plataforma Actual, Issue 2022, 2022, ISBN 978-84-18927-39-3
Publisher: Plataforma Actual