Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmerica

Informazioni relative al progetto

DIABFRAIL-LATAM

ID dell’accordo di sovvenzione: 825546

DOI

10.3030/825546

Progetto chiuso

Data della firma CE 3 Dicembre 2018

Data di avvio 1 Gennaio 2019

Data di completamento 31 Dicembre 2024

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 3 991 925,00

Contributo UE

€ 3 891 925,00

Coordinato da

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (4)

Production and validation of training material
Project Webpage & and Visual identity report
Training of study personnel
Report Advocacy and training sessions

Documents, reports (16)

Scaling-up strategy
Feasibility Questionnaires

Feasibility Questionnaires: Designed and sent to the sites to explore the characteristics of the sites involved in the study (number of physicians, primary care or hospital, population covered by the trial site, number of nurses, administrative resources, type of population (economical resources, dispersion, urban/rural)

Final clinical trial report
Report about the scaling up process
Interim monitoring Dissemination, communication & exploitation report
statistical and health economic plan
Progress Report

Progress Report Its aims to make an assessment of the level of compliance of the project implementation with respect to the plan foreseen for its execution including quality assurance deliverables and milestones and use of resources

Preparation of a risk mitigation plan
Risk plan
Preparation of a monitoring plan
Economical resources questionnaire
Final Dissemination, communication & exploitation report
Appointment of the standardisation team
Midterm recruitment report
Final statistical and health economic analysis report
Initial PEDR

Other (3)

Final database available to be uploaded to the Extended Open Research Data Pilot
Project Handbook: Guidelines for partners to consult management procedures
Devices (platform and all regarding devices)

The adherence to the study will be assess through two different methods: Diaries (to self-report the participant or carer the adherence to the study) and Kronowise device (to evaluate the adherence to the programme and physical activity in intervention group)

Demonstrators, pilots, prototypes (4)

Refined plan for the Exploitation and Dissemination of the project results
Clinical Trial Methodology including training manuals, e learning package
First study subject approvals package: protocol approved, registration number in a WHO and Clinicaltrials.gov and ERB and other Regulatory Authorities (if applicable) approval prior to enrolment the first participant

First study subject approvals package protocol approved registration number in a WHO and Clinicaltrialsgov and ERB and other Regulatory Authorities if applicable approval prior to enrolment the first participant

Training and Educational Workshop

Pubblicazioni

Peer reviewed articles (16)

Residual effects of 12 weeks of power‐oriented resistance training plus high‐intensity interval training on muscle dysfunction, systemic oxidative damage, and antioxidant capacity after 10 months of training cessation in older people with <scp>COPD</scp>

Autori: Ivan Baltasar‐Fernandez, Jose Losa‐Reyna, Aitor Carretero, Carlos Rodriguez‐Lopez, Ana Alfaro‐Acha, Amelia Guadalupe‐Grau, Ignacio Ara, Luis M. Alegre, Mari Carmen Gomez‐Cabrera, Francisco J. García‐García, Julian Alcazar
Pubblicato in: Scandinavian Journal of Medicine &amp; Science in Sports, Numero 33, 2023, Pagina/e 1661-1676, ISSN 0905-7188
Editore: Blackwell Publishing Inc.
DOI: 10.1111/sms.14428

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Autori: Luis Filipe Costa-Machado, Esther Garcia-Dominguez, Rebecca L. McIntyre, Jose Luis Lopez-Aceituno, Álvaro Ballesteros-Gonzalez, Andrea Tapia-Gonzalez, David Fabregat-Safont, Tobias Eisenberg, Jesús Gomez, Adrian Plaza, Aranzazu Sierra-Ramirez, Manuel Perez, David Villanueva-Bermejo, Tiziana Fornari, María Isabel Loza, Gonzalo Herradon, Sebastian J. Hofer, Christoph Magnes, Frank Madeo, Janet S.
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38410-y

Free radicals in Alzheimer's disease: From pathophysiology to clinical trial results

Autori: José Viña, Consuelo Borrás, Cristina Mas-Bargues
Pubblicato in: Free Radical Biology and Medicine, Numero 225, 2025, Pagina/e 296-301, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.09.051

Phenotypic upregulation of hexocylceramides and ether‐linked phosphocholines as markers of human extreme longevity

Autori: Anna Fernàndez‐Bernal, Joaquim Sol, José Daniel Galo‐Licona, Natàlia Mota‐Martorell, Cristina Mas‐Bargues, Ángel Belenguer‐Varea, Èlia Obis, José Viña, Consuelo Borrás, Mariona Jové, Reinald Pamplona
Pubblicato in: Aging Cell, 2024, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.14429

Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study

Autori: Mariana Nepomuceno, Paloma Monllor, Maria Jose Cardells, Artemis Ftara, Maria Magallon, Francisco Dasí, Mari Carmen Badia, Jose Viña, Ana Lloret
Pubblicato in: Free Radical Biology and Medicine, Numero 215, 2024, Pagina/e 56-63, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.02.021

Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease

Autori: María-Ángeles Bonmatí-Carrión, Maria-Angeles Rol
Pubblicato in: Antioxidants, Numero 13, 2024, Pagina/e 34, ISSN 2076-3921
Editore: Antioxidants
DOI: 10.3390/antiox13010034

The repeated bout effect evokes the training-induced skeletal muscle cellular memory

Autori: Miguel Calvo-Rubio, Esther Garcia-Dominguez, Eva Tamayo-Torres, Silvana Soto-Rodríguez, Gloria Olaso-Gonzalez, Luigi Ferrucci, Rafael de Cabo, Maria Carmen Gómez-Cabrera
Pubblicato in: Free Radical Biology and Medicine, Numero 225, 2025, Pagina/e 247-254, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.09.047

Diet and exercise in frailty and sarcopenia. Molecular aspects

Autori: Fernando Millan-Domingo, Esther Garcia-Dominguez, Juan Gambini, Gloria Olaso-Gonzalez, Jose Viña, Maria Carmen Gomez-Cabrera
Pubblicato in: Molecular Aspects of Medicine, Numero 100, 2024, Pagina/e 101322, ISSN 0098-2997
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101322

Living at the Wrong Time: Effects of Unmatching Official Time in Portugal and Western Spain

Autori: Bonmatí-Carrión MÁ, Casado-Ramirez E, Moreno-Casbas MT, Campos M, ModulEN Consortium, Madrid JA, Rol MA.
Pubblicato in: Biology (Basel), Numero 11(8), 2022, ISSN 2079-7737
Editore: MDPI
DOI: 10.3390/biology11081130.

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

Autori: Mikel Izquierdo, Philipe de Souto Barreto, Hidenori Arai, Heike A. Bischoff-Ferrari, Eduardo L. Cadore, Matteo Cesari, Liang-Kung Chen, Paul M. Coen, Kerry S. Courneya, Gustavo Duque, Luigi Ferrucci, Roger A. Fielding, Antonio García-Hermoso, Luis Miguel Gutiérrez-Robledo, Stephen D.R. Harridge, Ben Kirk, Stephen Kritchevsky, Francesco Landi, Norman Lazarus, Teresa Liu-Ambrose, Emanuele Marzetti
Pubblicato in: The Journal of nutrition, health and aging, Numero 29, 2025, Pagina/e 100401, ISSN 1279-7707
Editore: SERDI Publisher
DOI: 10.1016/j.jnha.2024.100401

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.

Autori: Sanz-Ros J, Romero-García N, Mas-Bargues C, Monleón D, Gordevicius J, Brooke RT, Dromant M, Díaz A, Derevyanko A, Guío-Carrión A, Román-Domínguez A, Inglés M, Blasco MA, Horvath S, Viña J, Borrás C.
Pubblicato in: Sci Adv., Numero Oct 2022, 2022, Pagina/e eabq2226, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abq2226

Phase Response Curve to Light under Ambulatory Conditions: A Pilot Study for Potential Application to Daylight Saving Time Transitions

Autori: Raquel Arguelles-Prieto, Juan Antonio Madrid , Maria Angeles Rol, María Ángeles Bonmatí-Carrión
Pubblicato in: Biology (Basel), Numero 11(11), 2022, ISSN 2079-7737
Editore: MDPI

Multimodal cell atlas of the ageing human skeletal muscle

Autori: Yiwei Lai, Ignacio Ramírez-Pardo, Joan Isern, Juan An, Eusebio Perdiguero, Antonio L. Serrano, Jinxiu Li, Esther García-Domínguez, Jessica Segalés, Pengcheng Guo, Vera Lukesova, Eva Andrés, Jing Zuo, Yue Yuan, Chuanyu Liu, José Viña, Julio Doménech-Fernández, Mari Carmen Gómez-Cabrera, Yancheng Song, Longqi Liu, Xun Xu, Pura Muñoz-Cánoves, Miguel A. Esteban
Pubblicato in: Nature, Numero 629, 2024, Pagina/e 154-164, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07348-6

Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer’s disease

Autori: Angela G. Correas, Gloria Olaso-Gonzalez, Marta Roca, Mari Carmen Blanco-Gandía, Carla Nascimento, Agustin Lahoz, Marta Rodriguez-Arias, José Miñarro, Mari Carmen Gomez-Cabrera, José Viña
Pubblicato in: Redox Biology, Numero 75, 2024, Pagina/e 103242, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2024.103242

Genistein, A Phytoestrogen, Delays the Transition to Dementia in Prodromal Alzheimer’s Disease Patients

Autori: José Viña, Consuelo Borrás, Cristina Mas-Bargues
Pubblicato in: Journal of Alzheimer's Disease, Numero 101, 2024, Pagina/e S275-S283, ISSN 1387-2877
Editore: IOS Press
DOI: 10.3233/jad-240308

Molecular mechanisms of cancer cachexia. Role of exercise training

Autori: Eva Tamayo-Torres, Amanda Garrido, Rafael de Cabo, Julián Carretero, María Carmen Gómez-Cabrera
Pubblicato in: Molecular Aspects of Medicine, Numero 99, 2024, Pagina/e 101293, ISSN 0098-2997
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101293

Non-peer reviewed articles (2)

Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice

Autori: Bernier M, Enamorado IN, Gómez-Cabrera MC, Calvo-Rubio M, González-Reyes JA, Price NL, Cortés-Rodríguez AB, Rodríguez-Aguilera JC, Rodríguez-López S, Mitchell SJ, Murt KN, Kalafut K, Williams KM, Ward CW, Stains JP, Brea-Calvo G, Villalba JM, Cortassa S, Aon MA, de Cabo R.
Pubblicato in: Aging, Numero Jun 27;8(1):8, 2022, Pagina/e 8, ISSN 1945-4589
Editore: NPJ

Glucosamine Supplementation Improves Physical Performance in Trained Mice.

Autori: DE LA Rosa A, Olaso-Gonzalez G, Garcia-Dominguez E, Mastaloudis A, Hester SN, Wood SM, Gomez-Cabrera MC, Viña J.
Pubblicato in: Med Sci Sports Exerc., Numero Mar 1;54(3):466-474., 2022, Pagina/e 466-474, ISSN 1530-0315
Editore: wolters kluwer
DOI: 10.1249/mss.0000000000002821

Other (4)

Real-Life Outcomes of a Multicomponent Exercise Intervention in Community-Dwelling Frail Older Adults and Its Association with Nutritional-Related Factors

Autori: Millan-Domingo F, Tarazona-Santabalbina FJ, Carretero A, Olaso-Gonzalez G, Viña J, Gomez-Cabrera MC.
Pubblicato in: Nutrients, Numero Dec 2022, 2022, Pagina/e 5147, ISSN 2072-6643
Editore: MDPI
DOI: 10.1038/s41514-022-00089-8

Test de los cuatro tiempos. Intelectual property registration. NÚMERO DE ASIENTO REGISTRAL 08 / 2022 / 508

Autori: Rol MA, Gonzalez-Romero P, Madrid JA, Campos M, Martínez-Madrid MJ, Rodriguez-Morilla B.
Pubblicato in: 2022
Editore: -

Glucose 6-P Dehydrogenase-An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise.

Autori: García-Domínguez E, Carretero A, Viña-Almunia A, Domenech-Fernandez J, Olaso-Gonzalez G, Viña J, Gomez-Cabrera MC.
Pubblicato in: Cells, Numero Sep 28;11(19):3041, 2022, Pagina/e 3041, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11193041

Que nada te quite el sueño

Autori: Bonmatí Carrión MA
Pubblicato in: Editorial Crítica, Numero 2023, 2023, ISBN 978-84-9199-497-8
Editore: Editorial Crítica

Conference proceedings (1)

El sueño el cuarto pilar de la salud

Autori: Madrid JA, Tomas-Loba A, Rol MA.
Pubblicato in: dossies revista SEBBM, Numero 44896, 2022, Pagina/e 8
Editore: SEBBM

Monographic books (1)

Cronobiología. Una guía para descubrir tu reloj biológico.

Autori: Madrid JA
Pubblicato in: Plataforma Actual, Numero 2022, 2022, ISBN 978-84-18927-39-3
Editore: Plataforma Actual