Scaling-up of and evidence-based intervention programme in older people with Diabetes and Frailty in LatinAmerica

Información del proyecto

DIABFRAIL-LATAM

Identificador del acuerdo de subvención: 825546

DOI

10.3030/825546

Proyecto cerrado

Fecha de la firma de la CE 3 Diciembre 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 3 991 925,00

Aportación de la UE

€ 3 891 925,00

Coordinado por

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (4)

Production and validation of training material
Project Webpage & and Visual identity report
Training of study personnel
Report Advocacy and training sessions

Documents, reports (16)

Scaling-up strategy
Feasibility Questionnaires

Feasibility Questionnaires: Designed and sent to the sites to explore the characteristics of the sites involved in the study (number of physicians, primary care or hospital, population covered by the trial site, number of nurses, administrative resources, type of population (economical resources, dispersion, urban/rural)

Final clinical trial report
Report about the scaling up process
Interim monitoring Dissemination, communication & exploitation report
statistical and health economic plan
Progress Report

Progress Report Its aims to make an assessment of the level of compliance of the project implementation with respect to the plan foreseen for its execution including quality assurance deliverables and milestones and use of resources

Preparation of a risk mitigation plan
Risk plan
Preparation of a monitoring plan
Economical resources questionnaire
Final Dissemination, communication & exploitation report
Appointment of the standardisation team
Midterm recruitment report
Final statistical and health economic analysis report
Initial PEDR

Other (3)

Final database available to be uploaded to the Extended Open Research Data Pilot
Project Handbook: Guidelines for partners to consult management procedures
Devices (platform and all regarding devices)

The adherence to the study will be assess through two different methods: Diaries (to self-report the participant or carer the adherence to the study) and Kronowise device (to evaluate the adherence to the programme and physical activity in intervention group)

Demonstrators, pilots, prototypes (4)

Refined plan for the Exploitation and Dissemination of the project results
Clinical Trial Methodology including training manuals, e learning package
First study subject approvals package: protocol approved, registration number in a WHO and Clinicaltrials.gov and ERB and other Regulatory Authorities (if applicable) approval prior to enrolment the first participant

First study subject approvals package protocol approved registration number in a WHO and Clinicaltrialsgov and ERB and other Regulatory Authorities if applicable approval prior to enrolment the first participant

Training and Educational Workshop

Publicaciones

Peer reviewed articles (16)

Residual effects of 12 weeks of power‐oriented resistance training plus high‐intensity interval training on muscle dysfunction, systemic oxidative damage, and antioxidant capacity after 10 months of training cessation in older people with <scp>COPD</scp>

Autores: Ivan Baltasar‐Fernandez, Jose Losa‐Reyna, Aitor Carretero, Carlos Rodriguez‐Lopez, Ana Alfaro‐Acha, Amelia Guadalupe‐Grau, Ignacio Ara, Luis M. Alegre, Mari Carmen Gomez‐Cabrera, Francisco J. García‐García, Julian Alcazar
Publicado en: Scandinavian Journal of Medicine &amp; Science in Sports, Edición 33, 2023, Página(s) 1661-1676, ISSN 0905-7188
Editor: Blackwell Publishing Inc.
DOI: 10.1111/sms.14428

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Autores: Luis Filipe Costa-Machado, Esther Garcia-Dominguez, Rebecca L. McIntyre, Jose Luis Lopez-Aceituno, Álvaro Ballesteros-Gonzalez, Andrea Tapia-Gonzalez, David Fabregat-Safont, Tobias Eisenberg, Jesús Gomez, Adrian Plaza, Aranzazu Sierra-Ramirez, Manuel Perez, David Villanueva-Bermejo, Tiziana Fornari, María Isabel Loza, Gonzalo Herradon, Sebastian J. Hofer, Christoph Magnes, Frank Madeo, Janet S.
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38410-y

Free radicals in Alzheimer's disease: From pathophysiology to clinical trial results

Autores: José Viña, Consuelo Borrás, Cristina Mas-Bargues
Publicado en: Free Radical Biology and Medicine, Edición 225, 2025, Página(s) 296-301, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.09.051

Phenotypic upregulation of hexocylceramides and ether‐linked phosphocholines as markers of human extreme longevity

Autores: Anna Fernàndez‐Bernal, Joaquim Sol, José Daniel Galo‐Licona, Natàlia Mota‐Martorell, Cristina Mas‐Bargues, Ángel Belenguer‐Varea, Èlia Obis, José Viña, Consuelo Borrás, Mariona Jové, Reinald Pamplona
Publicado en: Aging Cell, 2024, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.14429

Redox-associated changes in healthy individuals at risk of Alzheimer's disease. A ten-year follow-up study

Autores: Mariana Nepomuceno, Paloma Monllor, Maria Jose Cardells, Artemis Ftara, Maria Magallon, Francisco Dasí, Mari Carmen Badia, Jose Viña, Ana Lloret
Publicado en: Free Radical Biology and Medicine, Edición 215, 2024, Página(s) 56-63, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.02.021

Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease

Autores: María-Ángeles Bonmatí-Carrión, Maria-Angeles Rol
Publicado en: Antioxidants, Edición 13, 2024, Página(s) 34, ISSN 2076-3921
Editor: Antioxidants
DOI: 10.3390/antiox13010034

The repeated bout effect evokes the training-induced skeletal muscle cellular memory

Autores: Miguel Calvo-Rubio, Esther Garcia-Dominguez, Eva Tamayo-Torres, Silvana Soto-Rodríguez, Gloria Olaso-Gonzalez, Luigi Ferrucci, Rafael de Cabo, Maria Carmen Gómez-Cabrera
Publicado en: Free Radical Biology and Medicine, Edición 225, 2025, Página(s) 247-254, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2024.09.047

Diet and exercise in frailty and sarcopenia. Molecular aspects

Autores: Fernando Millan-Domingo, Esther Garcia-Dominguez, Juan Gambini, Gloria Olaso-Gonzalez, Jose Viña, Maria Carmen Gomez-Cabrera
Publicado en: Molecular Aspects of Medicine, Edición 100, 2024, Página(s) 101322, ISSN 0098-2997
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101322

Living at the Wrong Time: Effects of Unmatching Official Time in Portugal and Western Spain

Autores: Bonmatí-Carrión MÁ, Casado-Ramirez E, Moreno-Casbas MT, Campos M, ModulEN Consortium, Madrid JA, Rol MA.
Publicado en: Biology (Basel), Edición 11(8), 2022, ISSN 2079-7737
Editor: MDPI
DOI: 10.3390/biology11081130.

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

Autores: Mikel Izquierdo, Philipe de Souto Barreto, Hidenori Arai, Heike A. Bischoff-Ferrari, Eduardo L. Cadore, Matteo Cesari, Liang-Kung Chen, Paul M. Coen, Kerry S. Courneya, Gustavo Duque, Luigi Ferrucci, Roger A. Fielding, Antonio García-Hermoso, Luis Miguel Gutiérrez-Robledo, Stephen D.R. Harridge, Ben Kirk, Stephen Kritchevsky, Francesco Landi, Norman Lazarus, Teresa Liu-Ambrose, Emanuele Marzetti
Publicado en: The Journal of nutrition, health and aging, Edición 29, 2025, Página(s) 100401, ISSN 1279-7707
Editor: SERDI Publisher
DOI: 10.1016/j.jnha.2024.100401

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.

Autores: Sanz-Ros J, Romero-García N, Mas-Bargues C, Monleón D, Gordevicius J, Brooke RT, Dromant M, Díaz A, Derevyanko A, Guío-Carrión A, Román-Domínguez A, Inglés M, Blasco MA, Horvath S, Viña J, Borrás C.
Publicado en: Sci Adv., Edición Oct 2022, 2022, Página(s) eabq2226, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.abq2226

Phase Response Curve to Light under Ambulatory Conditions: A Pilot Study for Potential Application to Daylight Saving Time Transitions

Autores: Raquel Arguelles-Prieto, Juan Antonio Madrid , Maria Angeles Rol, María Ángeles Bonmatí-Carrión
Publicado en: Biology (Basel), Edición 11(11), 2022, ISSN 2079-7737
Editor: MDPI

Multimodal cell atlas of the ageing human skeletal muscle

Autores: Yiwei Lai, Ignacio Ramírez-Pardo, Joan Isern, Juan An, Eusebio Perdiguero, Antonio L. Serrano, Jinxiu Li, Esther García-Domínguez, Jessica Segalés, Pengcheng Guo, Vera Lukesova, Eva Andrés, Jing Zuo, Yue Yuan, Chuanyu Liu, José Viña, Julio Doménech-Fernández, Mari Carmen Gómez-Cabrera, Yancheng Song, Longqi Liu, Xun Xu, Pura Muñoz-Cánoves, Miguel A. Esteban
Publicado en: Nature, Edición 629, 2024, Página(s) 154-164, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-024-07348-6

Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer’s disease

Autores: Angela G. Correas, Gloria Olaso-Gonzalez, Marta Roca, Mari Carmen Blanco-Gandía, Carla Nascimento, Agustin Lahoz, Marta Rodriguez-Arias, José Miñarro, Mari Carmen Gomez-Cabrera, José Viña
Publicado en: Redox Biology, Edición 75, 2024, Página(s) 103242, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2024.103242

Genistein, A Phytoestrogen, Delays the Transition to Dementia in Prodromal Alzheimer’s Disease Patients

Autores: José Viña, Consuelo Borrás, Cristina Mas-Bargues
Publicado en: Journal of Alzheimer's Disease, Edición 101, 2024, Página(s) S275-S283, ISSN 1387-2877
Editor: IOS Press
DOI: 10.3233/jad-240308

Molecular mechanisms of cancer cachexia. Role of exercise training

Autores: Eva Tamayo-Torres, Amanda Garrido, Rafael de Cabo, Julián Carretero, María Carmen Gómez-Cabrera
Publicado en: Molecular Aspects of Medicine, Edición 99, 2024, Página(s) 101293, ISSN 0098-2997
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101293

Non-peer reviewed articles (2)

Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice

Autores: Bernier M, Enamorado IN, Gómez-Cabrera MC, Calvo-Rubio M, González-Reyes JA, Price NL, Cortés-Rodríguez AB, Rodríguez-Aguilera JC, Rodríguez-López S, Mitchell SJ, Murt KN, Kalafut K, Williams KM, Ward CW, Stains JP, Brea-Calvo G, Villalba JM, Cortassa S, Aon MA, de Cabo R.
Publicado en: Aging, Edición Jun 27;8(1):8, 2022, Página(s) 8, ISSN 1945-4589
Editor: NPJ

Glucosamine Supplementation Improves Physical Performance in Trained Mice.

Autores: DE LA Rosa A, Olaso-Gonzalez G, Garcia-Dominguez E, Mastaloudis A, Hester SN, Wood SM, Gomez-Cabrera MC, Viña J.
Publicado en: Med Sci Sports Exerc., Edición Mar 1;54(3):466-474., 2022, Página(s) 466-474, ISSN 1530-0315
Editor: wolters kluwer
DOI: 10.1249/mss.0000000000002821

Other (4)

Real-Life Outcomes of a Multicomponent Exercise Intervention in Community-Dwelling Frail Older Adults and Its Association with Nutritional-Related Factors

Autores: Millan-Domingo F, Tarazona-Santabalbina FJ, Carretero A, Olaso-Gonzalez G, Viña J, Gomez-Cabrera MC.
Publicado en: Nutrients, Edición Dec 2022, 2022, Página(s) 5147, ISSN 2072-6643
Editor: MDPI
DOI: 10.1038/s41514-022-00089-8

Test de los cuatro tiempos. Intelectual property registration. NÚMERO DE ASIENTO REGISTRAL 08 / 2022 / 508

Autores: Rol MA, Gonzalez-Romero P, Madrid JA, Campos M, Martínez-Madrid MJ, Rodriguez-Morilla B.
Publicado en: 2022
Editor: -

Glucose 6-P Dehydrogenase-An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise.

Autores: García-Domínguez E, Carretero A, Viña-Almunia A, Domenech-Fernandez J, Olaso-Gonzalez G, Viña J, Gomez-Cabrera MC.
Publicado en: Cells, Edición Sep 28;11(19):3041, 2022, Página(s) 3041, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11193041

Que nada te quite el sueño

Autores: Bonmatí Carrión MA
Publicado en: Editorial Crítica, Edición 2023, 2023, ISBN 978-84-9199-497-8
Editor: Editorial Crítica

Conference proceedings (1)

El sueño el cuarto pilar de la salud

Autores: Madrid JA, Tomas-Loba A, Rol MA.
Publicado en: dossies revista SEBBM, Edición 44896, 2022, Página(s) 8
Editor: SEBBM

Monographic books (1)

Cronobiología. Una guía para descubrir tu reloj biológico.

Autores: Madrid JA
Publicado en: Plataforma Actual, Edición 2022, 2022, ISBN 978-84-18927-39-3
Editor: Plataforma Actual