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Establishment and Exploitation of a European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer

Deliverables

Training course programme

The biobank of Universidad de Chile will coordinate the implementation of 1 theoretical courses 2 days 2 handson training 3 days and 3 interview training for the personnel involved in patient recruitment in particular study nurses and Latin American PhD students A detailed training programme will be prepared in collaboration with the experts who designed and implemented the most recent National Health Surveys in Chile aiming at guaranteeing uniform application of standardized study protocols across all recruitment sites

Programme advanced courses

Final programmes for first advanced courses in months 921334557

Advanced courses

Advanced courses taken place in months 1224364860

Recruitment PhD students

Recruitment of three PhD students for first training round

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Publications

RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling

Author(s): Dominique Scherer, Marcela Dávila López, Benjamin Goeppert, Sanna Abrahamsson, Rosa González Silos, Igor Nova, Katherine Marcelain, Juan C. Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge, Stephanie Roessler, Justo Lorenzo Bermejo
Published in: Cancers, 12/9, 2020, Page(s) 2510, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092510

Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype data

Author(s): Heike Deutelmoser, Dominique Scherer, Hermann Brenner, Melanie Waldenberger, Karsten Suhre, Gabi Kastenmüller, Justo Lorenzo Bermejo
Published in: Briefings in Bioinformatics, 2020, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbaa230

Gallstones, Body Mass Index, C‐Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data

Author(s): Carol Barahona Ponce, Dominique Scherer, Regina Brinster, Felix Boekstegers, Katherine Marcelain, Valentina Gárate‐Calderón, Bettina Müller, Gonzalo Toro, Javier Retamales, Olga Barajas, Monica Ahumada, Erik Morales, Armando Rojas, Verónica Sanhueza, Denisse Loader, María Teresa Rivera, Lorena Gutiérrez, Giuliano Bernal, Alejandro Ortega, Domingo Montalvo, Sergio Portiño, Maria Enriqueta
Published in: Hepatology, 73/5, 2021, Page(s) 1783-1796, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31537

Inbreeding, native American ancestry and child mortality: Linking human selection and paediatric medicine.

Author(s): Fabienne Koenigstein; Felix Boekstegers; James F. Wilson; Macarena Fuentes-Guajardo; Rolando González-José; Gabriel Bedoya; Maria Cátira Bortolini; Victor Acuña-Alonzo; Carla Gallo; Andrés Ruiz Linares; Andrés Ruiz Linares; Andrés Ruiz Linares; Francisco Rothhammer; Justo Lorenzo Bermejo
Published in: Human Molecular Genetics, 2, 2021, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddab302

Validation of an NGS Panel Designed for Detection of Actionable Mutations in Tumors Common in Latin America.

Author(s): Mauricio Salvo; Evelin González-Feliú; Jessica Toro; Iván Gallegos; Ignacio Maureira; Nicolás Miranda-González; Olga Barajas; Eva Bustamante; Monica Ahumada; Alicia Colombo; Ricardo Armisen; Camilo Villamán; Carolina Ibañez; María Loreto Bravo; Verónica Sanhueza; M. Loreto Spencer; Gonzalo de Toro; Erik Morales; Carolina Bizama; Patricia García; Ana María Carrasco; Lorena Gutiérrez; Ju
Published in: Journal of Personlized Medicine, 2, 2021, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm11090899

Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression

Author(s): Alice Blandino, Dominique Scherer, Trine B. Rounge, Sinan U. Umu, Felix Boekstegers, Carol Barahona Ponce, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo de Toro, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Ber
Published in: Cancers, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030634

Risk of Gynecological Cancers in Cholecystectomized Women: A Large Nationwide Cohort Study

Author(s): Elham Kharazmi, Kristina Sundquist, Jan Sundquist, Mahdi Fallah, Justo Lorenzo Bermejo
Published in: Cancers, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061484

Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer

Author(s): Johannes Brägelmann, Carol Barahona Ponce, Katherine Marcelain, Stephanie Roessler, Benjamin Goeppert, Ivan Gallegos, Alicia Colombo, Verónica Sanhueza, Erik Morales, María Teresa Rivera, Gonzalo de Toro, Alejandro Ortega, Bettina Müller, Fernando Gabler, Dominique Scherer, Melanie Waldenberger, Eva Reischl, Felix Boekstegers, Valentina Garate-Calderon, Sinan U. Umu, Trine B. Rounge, Odilia Po
Published in: Hepatology, 2021, ISSN 1527-3350
Publisher: AASLD
DOI: 10.1002/hep.31585