Establishment and Exploitation of a European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer

Project Information

EULAT Eradicate GBC

Grant agreement ID: 825741

DOI

10.3030/825741

EC signature date 21 August 2019

Start date 1 December 2019

End date 30 November 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 4 675 932,30

EU contribution

€ 4 675 932,30

Coordinated by

UNIVERSITATSKLINIKUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Training course programme

The biobank of Universidad de Chile will coordinate the implementation of 1 theoretical courses 2 days 2 handson training 3 days and 3 interview training for the personnel involved in patient recruitment in particular study nurses and Latin American PhD students A detailed training programme will be prepared in collaboration with the experts who designed and implemented the most recent National Health Surveys in Chile aiming at guaranteeing uniform application of standardized study protocols across all recruitment sites

Programme advanced courses

Final programmes for first advanced courses in months 921334557

Other (2)

Advanced courses

Advanced courses taken place in months 1224364860

Recruitment PhD students

Recruitment of three PhD students for first training round

Publications

Peer reviewed articles (17)

Inbreeding and Gallbladder Cancer Risk: Homozygosity Associations Adjusted for Indigenous American Ancestry, BMI, and Genetic Risk of Gallstone Disease

Author(s): Francisco Ceballos, Felix Boekstegers, Dominique Scherer, Carol Barahona Ponce, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo de Toro, Allan Vera Kortmann, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Bertrán,
Published in: Cancers, Issue 16, 2025, Page(s) 4195, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16244195

NGS allele counts versus called genotypes for testing genetic association

Author(s): Rosa González Silos, Christine Fischer, Justo Lorenzo Bermejo
Published in: Computational and Structural Biotechnology Journal, 2022, Page(s) 3729-3733, ISSN 2001-0370
Publisher: Elsevier on behalf of Research Network of Computational and Structural Biotechnology
DOI: 10.1016/j.csbj.2022.07.016

Small-RNA sequencing reveals potential serum biomarkers for gallbladder cancer: Results from a three-stage collaborative study of large European prospective cohorts

Author(s): Alice Blandino, Dominique Scherer, Felix Boekstegers, Trine B. Rounge, Hilde Langseth, Stephanie Roessler, Kristian Hveem, Hermann Brenner, Sonali Pechlivanis, Melanie Waldenberger, Justo Lorenzo Bermejo
Published in: European Journal of Cancer, Issue 214, 2024, Page(s) 115138, ISSN 0959-8049
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2024.115138

RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling

Author(s): Dominique Scherer, Marcela Dávila López, Benjamin Goeppert, Sanna Abrahamsson, Rosa González Silos, Igor Nova, Katherine Marcelain, Juan C. Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge, Stephanie Roessler, Justo Lorenzo Bermejo
Published in: Cancers, Issue 12/9, 2020, Page(s) 2510, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092510

Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers

Author(s): Zollner L., Boekstegers F., Barahona Ponce C., Scherer D., Marcelain K., Garate-Calderon V., Waldenberger M., Morales E., Rojas A., Munoz C., Retamales J., De Toro G., Kortmann A. V., Barajas O., Rivera M. T., Cortes A., Loader D., Saavedra J., Gutierrez L., Ortega A., Bertran M. E., Bartolotti L., Gabler F., Campos M., Alvarado J., Moisan F., Spencer L., Nervi B., Carvajal D., Losada H., Almau M.
Published in: Cancers, 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15164033

Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype data

Author(s): Heike Deutelmoser, Dominique Scherer, Hermann Brenner, Melanie Waldenberger, Karsten Suhre, Gabi Kastenmüller, Justo Lorenzo Bermejo
Published in: Briefings in Bioinformatics, 2020, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbaa230

Gallstones, Cholecystectomy, and Kidney Cancer: Observational and Mendelian Randomization Results Based on Large Cohorts

Author(s): Kharazmi E., Scherer D., Boekstegers F., Liang Q., Sundquist K., Sundquist J., Fallah M., Lorenzo Bermejo J.
Published in: Gastroenterology, 2023, ISSN 1528-0012
Publisher: AGA
DOI: 10.1053/j.gastro.2023.03.227

Gallstones, Body Mass Index, C‐Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data

Author(s): Carol Barahona Ponce, Dominique Scherer, Regina Brinster, Felix Boekstegers, Katherine Marcelain, Valentina Gárate‐Calderón, Bettina Müller, Gonzalo Toro, Javier Retamales, Olga Barajas, Monica Ahumada, Erik Morales, Armando Rojas, Verónica Sanhueza, Denisse Loader, María Teresa Rivera, Lorena Gutiérrez, Giuliano Bernal, Alejandro Ortega, Domingo Montalvo, Sergio Portiño, Maria Enriqueta
Published in: Hepatology, Issue 73/5, 2021, Page(s) 1783-1796, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31537

Data Resource Profile: EULAT Eradicate GBC: the European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer

Author(s): Dominique Scherer, Carol Barahona Ponce, Claudio Mengoa, Paola Montenegro, Hector Losada, Ana Lineth Garcia, Armando Rojas, Erik Morales, Allan Vera Kortmann, Loreto Spencer, Alejandro Ortega, Karina Vargas Valdebenito, Juan Carlos Roa, Cristina Inklemona, Alicia Colombo Flores, Romy Kirsten, Linda Zollner, Katherine Marcelain, Trine B Rounge, Hilde Langseth, Sarah Jane Lewis, Gerardo Francisco Ar
Published in: International Journal of Epidemiology, Issue 54, 2025, ISSN 1464-3685
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ije/dyaf127

Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country

Author(s): Boekstegers F., Scherer D., Barahona Ponce C., Marcelain K., Garate-Calderon V., Waldenberger M., Morales E., Rojas A., Monoz C., Retamales J., de Toro G., Barajas O., Rivera M. T., Cortes A., Loader D., Saavedra J., Gutierrez L., Ortega A., Bertran M. E., Bartolotti L., Gabler F., Campos M., Alvarado J., Moisan F., Spencer L., Nervi B., Carvajal-Hausdorf D., Losada H., Almau M., Fernandez P., Oll
Published in: International Journal of Cancer, 2023, ISSN 1097-0215
Publisher: Wiley
DOI: 10.1002/ijc.34607

Inbreeding, native American ancestry and child mortality: Linking human selection and paediatric medicine.

Author(s): Fabienne Koenigstein; Felix Boekstegers; James F. Wilson; Macarena Fuentes-Guajardo; Rolando González-José; Gabriel Bedoya; Maria Cátira Bortolini; Victor Acuña-Alonzo; Carla Gallo; Andrés Ruiz Linares; Andrés Ruiz Linares; Andrés Ruiz Linares; Francisco Rothhammer; Justo Lorenzo Bermejo
Published in: Human Molecular Genetics, Issue 2, 2021, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddab302

Validation of an NGS Panel Designed for Detection of Actionable Mutations in Tumors Common in Latin America.

Author(s): Mauricio Salvo; Evelin González-Feliú; Jessica Toro; Iván Gallegos; Ignacio Maureira; Nicolás Miranda-González; Olga Barajas; Eva Bustamante; Monica Ahumada; Alicia Colombo; Ricardo Armisen; Camilo Villamán; Carolina Ibañez; María Loreto Bravo; Verónica Sanhueza; M. Loreto Spencer; Gonzalo de Toro; Erik Morales; Carolina Bizama; Patricia García; Ana María Carrasco; Lorena Gutiérrez; Ju
Published in: Journal of Personlized Medicine, Issue 2, 2021, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm11090899

Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression

Author(s): Alice Blandino, Dominique Scherer, Trine B. Rounge, Sinan U. Umu, Felix Boekstegers, Carol Barahona Ponce, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo de Toro, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Ber
Published in: Cancers, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030634

Cholecystectomy and digestive cancer in Chile: Complementary results from interrupted time series and aggregated data analyses

Author(s): Constanza Gonzalez, Alfonso García‐Pérez, Bruno Nervi, César Munoz, Erik Morales, Hector Losada, Gina Merino‐Pereira, Francisco Rothhammer, Justo Lorenzo Bermejo
Published in: International Journal of Cancer, Issue 156, 2024, Page(s) 91-103, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.35138

Risk of Gynecological Cancers in Cholecystectomized Women: A Large Nationwide Cohort Study

Author(s): Elham Kharazmi, Kristina Sundquist, Jan Sundquist, Mahdi Fallah, Justo Lorenzo Bermejo
Published in: Cancers, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061484

Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer

Author(s): Johannes Brägelmann, Carol Barahona Ponce, Katherine Marcelain, Stephanie Roessler, Benjamin Goeppert, Ivan Gallegos, Alicia Colombo, Verónica Sanhueza, Erik Morales, María Teresa Rivera, Gonzalo de Toro, Alejandro Ortega, Bettina Müller, Fernando Gabler, Dominique Scherer, Melanie Waldenberger, Eva Reischl, Felix Boekstegers, Valentina Garate-Calderon, Sinan U. Umu, Trine B. Rounge, Odilia Po
Published in: Hepatology, 2021, ISSN 1527-3350
Publisher: AASLD
DOI: 10.1002/hep.31585

Development of an Application for Electronic Retrieval of Patient and Sample Information in Latin American Regions with a High Incidence of Gallbladder Cancer

Author(s): Sergio Guinez-Molinos, Jaime Gonzalez Diaz, Carol Barahona Ponce andJusto Lorenzo Bermejo
Published in: Journal of Personalized Medicine, 2022, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm12091476

Non-peer reviewed articles (2)

Reply

Author(s): Dominique Scherer, Felix Boekstegers, Justo Lorenzo Bermejo
Published in: Gastroenterology, Issue 165, 2024, Page(s) 1306-1307, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2023.08.018

International collaborative research to improve gallbladder cancer prevention

Author(s): Dominique Scherer, Rajiv Kumar, Justo Lorenzo Bermejo, null null, Carol Barahona Ponce, Claudio Mengoa, Paola Montenegro, Albert Torres, Cristian Pacheco, Hector Losada, Ana Lineth Garcia, Sidney Rojas Orellana, Armando Rojas, Erik Morales, César Muñoz-Castro, Gonzalo de Toro, Allan Vera Kortmann, Loreto Spencer, Fabrizio Moisán, Cristian Lindner, Alejandro Ortega, Karina Vargas Valdebenito, Br
Published in: Nature Reviews Gastroenterology & Hepatology, Issue 22, 2025, Page(s) 293-294, ISSN 1759-5045
Publisher: Nature Publishing Group
DOI: 10.1038/s41575-025-01061-z