Establishment and Exploitation of a European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer

Informations projet

EULAT Eradicate GBC

N° de convention de subvention: 825741

DOI

10.3030/825741

Date de signature de la CE 21 Août 2019

Date de début 1 Decembre 2019

Date de fin 30 Novembre 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 4 675 932,30

Contribution de l’UE

€ 4 675 932,30

Coordonné par

UNIVERSITATSKLINIKUM HEIDELBERG
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (2)

Training course programme

The biobank of Universidad de Chile will coordinate the implementation of 1 theoretical courses 2 days 2 handson training 3 days and 3 interview training for the personnel involved in patient recruitment in particular study nurses and Latin American PhD students A detailed training programme will be prepared in collaboration with the experts who designed and implemented the most recent National Health Surveys in Chile aiming at guaranteeing uniform application of standardized study protocols across all recruitment sites

Programme advanced courses

Final programmes for first advanced courses in months 921334557

Other (2)

Advanced courses

Advanced courses taken place in months 1224364860

Recruitment PhD students

Recruitment of three PhD students for first training round

Publications

Peer reviewed articles (17)

Inbreeding and Gallbladder Cancer Risk: Homozygosity Associations Adjusted for Indigenous American Ancestry, BMI, and Genetic Risk of Gallstone Disease

Auteurs: Francisco Ceballos, Felix Boekstegers, Dominique Scherer, Carol Barahona Ponce, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo de Toro, Allan Vera Kortmann, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Bertrán,
Publié dans: Cancers, Numéro 16, 2025, Page(s) 4195, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16244195

NGS allele counts versus called genotypes for testing genetic association

Auteurs: Rosa González Silos, Christine Fischer, Justo Lorenzo Bermejo
Publié dans: Computational and Structural Biotechnology Journal, 2022, Page(s) 3729-3733, ISSN 2001-0370
Éditeur: Elsevier on behalf of Research Network of Computational and Structural Biotechnology
DOI: 10.1016/j.csbj.2022.07.016

Small-RNA sequencing reveals potential serum biomarkers for gallbladder cancer: Results from a three-stage collaborative study of large European prospective cohorts

Auteurs: Alice Blandino, Dominique Scherer, Felix Boekstegers, Trine B. Rounge, Hilde Langseth, Stephanie Roessler, Kristian Hveem, Hermann Brenner, Sonali Pechlivanis, Melanie Waldenberger, Justo Lorenzo Bermejo
Publié dans: European Journal of Cancer, Numéro 214, 2024, Page(s) 115138, ISSN 0959-8049
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2024.115138

RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling

Auteurs: Dominique Scherer, Marcela Dávila López, Benjamin Goeppert, Sanna Abrahamsson, Rosa González Silos, Igor Nova, Katherine Marcelain, Juan C. Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge, Stephanie Roessler, Justo Lorenzo Bermejo
Publié dans: Cancers, Numéro 12/9, 2020, Page(s) 2510, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092510

Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers

Auteurs: Zollner L., Boekstegers F., Barahona Ponce C., Scherer D., Marcelain K., Garate-Calderon V., Waldenberger M., Morales E., Rojas A., Munoz C., Retamales J., De Toro G., Kortmann A. V., Barajas O., Rivera M. T., Cortes A., Loader D., Saavedra J., Gutierrez L., Ortega A., Bertran M. E., Bartolotti L., Gabler F., Campos M., Alvarado J., Moisan F., Spencer L., Nervi B., Carvajal D., Losada H., Almau M.
Publié dans: Cancers, 2023, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15164033

Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype data

Auteurs: Heike Deutelmoser, Dominique Scherer, Hermann Brenner, Melanie Waldenberger, Karsten Suhre, Gabi Kastenmüller, Justo Lorenzo Bermejo
Publié dans: Briefings in Bioinformatics, 2020, ISSN 1467-5463
Éditeur: Oxford University Press
DOI: 10.1093/bib/bbaa230

Gallstones, Cholecystectomy, and Kidney Cancer: Observational and Mendelian Randomization Results Based on Large Cohorts

Auteurs: Kharazmi E., Scherer D., Boekstegers F., Liang Q., Sundquist K., Sundquist J., Fallah M., Lorenzo Bermejo J.
Publié dans: Gastroenterology, 2023, ISSN 1528-0012
Éditeur: AGA
DOI: 10.1053/j.gastro.2023.03.227

Gallstones, Body Mass Index, C‐Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data

Auteurs: Carol Barahona Ponce, Dominique Scherer, Regina Brinster, Felix Boekstegers, Katherine Marcelain, Valentina Gárate‐Calderón, Bettina Müller, Gonzalo Toro, Javier Retamales, Olga Barajas, Monica Ahumada, Erik Morales, Armando Rojas, Verónica Sanhueza, Denisse Loader, María Teresa Rivera, Lorena Gutiérrez, Giuliano Bernal, Alejandro Ortega, Domingo Montalvo, Sergio Portiño, Maria Enriqueta
Publié dans: Hepatology, Numéro 73/5, 2021, Page(s) 1783-1796, ISSN 0270-9139
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/hep.31537

Data Resource Profile: EULAT Eradicate GBC: the European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer

Auteurs: Dominique Scherer, Carol Barahona Ponce, Claudio Mengoa, Paola Montenegro, Hector Losada, Ana Lineth Garcia, Armando Rojas, Erik Morales, Allan Vera Kortmann, Loreto Spencer, Alejandro Ortega, Karina Vargas Valdebenito, Juan Carlos Roa, Cristina Inklemona, Alicia Colombo Flores, Romy Kirsten, Linda Zollner, Katherine Marcelain, Trine B Rounge, Hilde Langseth, Sarah Jane Lewis, Gerardo Francisco Ar
Publié dans: International Journal of Epidemiology, Numéro 54, 2025, ISSN 1464-3685
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/ije/dyaf127

Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country

Auteurs: Boekstegers F., Scherer D., Barahona Ponce C., Marcelain K., Garate-Calderon V., Waldenberger M., Morales E., Rojas A., Monoz C., Retamales J., de Toro G., Barajas O., Rivera M. T., Cortes A., Loader D., Saavedra J., Gutierrez L., Ortega A., Bertran M. E., Bartolotti L., Gabler F., Campos M., Alvarado J., Moisan F., Spencer L., Nervi B., Carvajal-Hausdorf D., Losada H., Almau M., Fernandez P., Oll
Publié dans: International Journal of Cancer, 2023, ISSN 1097-0215
Éditeur: Wiley
DOI: 10.1002/ijc.34607

Inbreeding, native American ancestry and child mortality: Linking human selection and paediatric medicine.

Auteurs: Fabienne Koenigstein; Felix Boekstegers; James F. Wilson; Macarena Fuentes-Guajardo; Rolando González-José; Gabriel Bedoya; Maria Cátira Bortolini; Victor Acuña-Alonzo; Carla Gallo; Andrés Ruiz Linares; Andrés Ruiz Linares; Andrés Ruiz Linares; Francisco Rothhammer; Justo Lorenzo Bermejo
Publié dans: Human Molecular Genetics, Numéro 2, 2021, ISSN 0964-6906
Éditeur: Oxford University Press
DOI: 10.1093/hmg/ddab302

Validation of an NGS Panel Designed for Detection of Actionable Mutations in Tumors Common in Latin America.

Auteurs: Mauricio Salvo; Evelin González-Feliú; Jessica Toro; Iván Gallegos; Ignacio Maureira; Nicolás Miranda-González; Olga Barajas; Eva Bustamante; Monica Ahumada; Alicia Colombo; Ricardo Armisen; Camilo Villamán; Carolina Ibañez; María Loreto Bravo; Verónica Sanhueza; M. Loreto Spencer; Gonzalo de Toro; Erik Morales; Carolina Bizama; Patricia García; Ana María Carrasco; Lorena Gutiérrez; Ju
Publié dans: Journal of Personlized Medicine, Numéro 2, 2021, ISSN 2075-4426
Éditeur: MDPI
DOI: 10.3390/jpm11090899

Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression

Auteurs: Alice Blandino, Dominique Scherer, Trine B. Rounge, Sinan U. Umu, Felix Boekstegers, Carol Barahona Ponce, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo de Toro, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Ber
Publié dans: Cancers, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030634

Cholecystectomy and digestive cancer in Chile: Complementary results from interrupted time series and aggregated data analyses

Auteurs: Constanza Gonzalez, Alfonso García‐Pérez, Bruno Nervi, César Munoz, Erik Morales, Hector Losada, Gina Merino‐Pereira, Francisco Rothhammer, Justo Lorenzo Bermejo
Publié dans: International Journal of Cancer, Numéro 156, 2024, Page(s) 91-103, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ijc.35138

Risk of Gynecological Cancers in Cholecystectomized Women: A Large Nationwide Cohort Study

Auteurs: Elham Kharazmi, Kristina Sundquist, Jan Sundquist, Mahdi Fallah, Justo Lorenzo Bermejo
Publié dans: Cancers, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061484

Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer

Auteurs: Johannes Brägelmann, Carol Barahona Ponce, Katherine Marcelain, Stephanie Roessler, Benjamin Goeppert, Ivan Gallegos, Alicia Colombo, Verónica Sanhueza, Erik Morales, María Teresa Rivera, Gonzalo de Toro, Alejandro Ortega, Bettina Müller, Fernando Gabler, Dominique Scherer, Melanie Waldenberger, Eva Reischl, Felix Boekstegers, Valentina Garate-Calderon, Sinan U. Umu, Trine B. Rounge, Odilia Po
Publié dans: Hepatology, 2021, ISSN 1527-3350
Éditeur: AASLD
DOI: 10.1002/hep.31585

Development of an Application for Electronic Retrieval of Patient and Sample Information in Latin American Regions with a High Incidence of Gallbladder Cancer

Auteurs: Sergio Guinez-Molinos, Jaime Gonzalez Diaz, Carol Barahona Ponce andJusto Lorenzo Bermejo
Publié dans: Journal of Personalized Medicine, 2022, ISSN 2075-4426
Éditeur: MDPI
DOI: 10.3390/jpm12091476

Non-peer reviewed articles (2)

Reply

Auteurs: Dominique Scherer, Felix Boekstegers, Justo Lorenzo Bermejo
Publié dans: Gastroenterology, Numéro 165, 2024, Page(s) 1306-1307, ISSN 0016-5085
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2023.08.018

International collaborative research to improve gallbladder cancer prevention

Auteurs: Dominique Scherer, Rajiv Kumar, Justo Lorenzo Bermejo, null null, Carol Barahona Ponce, Claudio Mengoa, Paola Montenegro, Albert Torres, Cristian Pacheco, Hector Losada, Ana Lineth Garcia, Sidney Rojas Orellana, Armando Rojas, Erik Morales, César Muñoz-Castro, Gonzalo de Toro, Allan Vera Kortmann, Loreto Spencer, Fabrizio Moisán, Cristian Lindner, Alejandro Ortega, Karina Vargas Valdebenito, Br
Publié dans: Nature Reviews Gastroenterology & Hepatology, Numéro 22, 2025, Page(s) 293-294, ISSN 1759-5045
Éditeur: Nature Publishing Group
DOI: 10.1038/s41575-025-01061-z