Establishment and Exploitation of a European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer

Informazioni relative al progetto

EULAT Eradicate GBC

ID dell’accordo di sovvenzione: 825741

DOI

10.3030/825741

Data della firma CE 21 Agosto 2019

Data di avvio 1 Dicembre 2019

Data di completamento 30 Novembre 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 4 675 932,30

Contributo UE

€ 4 675 932,30

Coordinato da

UNIVERSITATSKLINIKUM HEIDELBERG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Training course programme

The biobank of Universidad de Chile will coordinate the implementation of 1 theoretical courses 2 days 2 handson training 3 days and 3 interview training for the personnel involved in patient recruitment in particular study nurses and Latin American PhD students A detailed training programme will be prepared in collaboration with the experts who designed and implemented the most recent National Health Surveys in Chile aiming at guaranteeing uniform application of standardized study protocols across all recruitment sites

Programme advanced courses

Final programmes for first advanced courses in months 921334557

Other (2)

Advanced courses

Advanced courses taken place in months 1224364860

Recruitment PhD students

Recruitment of three PhD students for first training round

Pubblicazioni

Peer reviewed articles (17)

Inbreeding and Gallbladder Cancer Risk: Homozygosity Associations Adjusted for Indigenous American Ancestry, BMI, and Genetic Risk of Gallstone Disease

Autori: Francisco Ceballos, Felix Boekstegers, Dominique Scherer, Carol Barahona Ponce, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo de Toro, Allan Vera Kortmann, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Bertrán,
Pubblicato in: Cancers, Numero 16, 2025, Pagina/e 4195, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers16244195

NGS allele counts versus called genotypes for testing genetic association

Autori: Rosa González Silos, Christine Fischer, Justo Lorenzo Bermejo
Pubblicato in: Computational and Structural Biotechnology Journal, 2022, Pagina/e 3729-3733, ISSN 2001-0370
Editore: Elsevier on behalf of Research Network of Computational and Structural Biotechnology
DOI: 10.1016/j.csbj.2022.07.016

Small-RNA sequencing reveals potential serum biomarkers for gallbladder cancer: Results from a three-stage collaborative study of large European prospective cohorts

Autori: Alice Blandino, Dominique Scherer, Felix Boekstegers, Trine B. Rounge, Hilde Langseth, Stephanie Roessler, Kristian Hveem, Hermann Brenner, Sonali Pechlivanis, Melanie Waldenberger, Justo Lorenzo Bermejo
Pubblicato in: European Journal of Cancer, Numero 214, 2024, Pagina/e 115138, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2024.115138

RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling

Autori: Dominique Scherer, Marcela Dávila López, Benjamin Goeppert, Sanna Abrahamsson, Rosa González Silos, Igor Nova, Katherine Marcelain, Juan C. Roa, David Ibberson, Sinan U. Umu, Trine Ballestad Rounge, Stephanie Roessler, Justo Lorenzo Bermejo
Pubblicato in: Cancers, Numero 12/9, 2020, Pagina/e 2510, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092510

Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers

Autori: Zollner L., Boekstegers F., Barahona Ponce C., Scherer D., Marcelain K., Garate-Calderon V., Waldenberger M., Morales E., Rojas A., Munoz C., Retamales J., De Toro G., Kortmann A. V., Barajas O., Rivera M. T., Cortes A., Loader D., Saavedra J., Gutierrez L., Ortega A., Bertran M. E., Bartolotti L., Gabler F., Campos M., Alvarado J., Moisan F., Spencer L., Nervi B., Carvajal D., Losada H., Almau M.
Pubblicato in: Cancers, 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15164033

Robust Huber-LASSO for improved prediction of protein, metabolite and gene expression levels relying on individual genotype data

Autori: Heike Deutelmoser, Dominique Scherer, Hermann Brenner, Melanie Waldenberger, Karsten Suhre, Gabi Kastenmüller, Justo Lorenzo Bermejo
Pubblicato in: Briefings in Bioinformatics, 2020, ISSN 1467-5463
Editore: Oxford University Press
DOI: 10.1093/bib/bbaa230

Gallstones, Cholecystectomy, and Kidney Cancer: Observational and Mendelian Randomization Results Based on Large Cohorts

Autori: Kharazmi E., Scherer D., Boekstegers F., Liang Q., Sundquist K., Sundquist J., Fallah M., Lorenzo Bermejo J.
Pubblicato in: Gastroenterology, 2023, ISSN 1528-0012
Editore: AGA
DOI: 10.1053/j.gastro.2023.03.227

Gallstones, Body Mass Index, C‐Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data

Autori: Carol Barahona Ponce, Dominique Scherer, Regina Brinster, Felix Boekstegers, Katherine Marcelain, Valentina Gárate‐Calderón, Bettina Müller, Gonzalo Toro, Javier Retamales, Olga Barajas, Monica Ahumada, Erik Morales, Armando Rojas, Verónica Sanhueza, Denisse Loader, María Teresa Rivera, Lorena Gutiérrez, Giuliano Bernal, Alejandro Ortega, Domingo Montalvo, Sergio Portiño, Maria Enriqueta
Pubblicato in: Hepatology, Numero 73/5, 2021, Pagina/e 1783-1796, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.31537

Data Resource Profile: EULAT Eradicate GBC: the European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer

Autori: Dominique Scherer, Carol Barahona Ponce, Claudio Mengoa, Paola Montenegro, Hector Losada, Ana Lineth Garcia, Armando Rojas, Erik Morales, Allan Vera Kortmann, Loreto Spencer, Alejandro Ortega, Karina Vargas Valdebenito, Juan Carlos Roa, Cristina Inklemona, Alicia Colombo Flores, Romy Kirsten, Linda Zollner, Katherine Marcelain, Trine B Rounge, Hilde Langseth, Sarah Jane Lewis, Gerardo Francisco Ar
Pubblicato in: International Journal of Epidemiology, Numero 54, 2025, ISSN 1464-3685
Editore: Oxford University Press (OUP)
DOI: 10.1093/ije/dyaf127

Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country

Autori: Boekstegers F., Scherer D., Barahona Ponce C., Marcelain K., Garate-Calderon V., Waldenberger M., Morales E., Rojas A., Monoz C., Retamales J., de Toro G., Barajas O., Rivera M. T., Cortes A., Loader D., Saavedra J., Gutierrez L., Ortega A., Bertran M. E., Bartolotti L., Gabler F., Campos M., Alvarado J., Moisan F., Spencer L., Nervi B., Carvajal-Hausdorf D., Losada H., Almau M., Fernandez P., Oll
Pubblicato in: International Journal of Cancer, 2023, ISSN 1097-0215
Editore: Wiley
DOI: 10.1002/ijc.34607

Inbreeding, native American ancestry and child mortality: Linking human selection and paediatric medicine.

Autori: Fabienne Koenigstein; Felix Boekstegers; James F. Wilson; Macarena Fuentes-Guajardo; Rolando González-José; Gabriel Bedoya; Maria Cátira Bortolini; Victor Acuña-Alonzo; Carla Gallo; Andrés Ruiz Linares; Andrés Ruiz Linares; Andrés Ruiz Linares; Francisco Rothhammer; Justo Lorenzo Bermejo
Pubblicato in: Human Molecular Genetics, Numero 2, 2021, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddab302

Validation of an NGS Panel Designed for Detection of Actionable Mutations in Tumors Common in Latin America.

Autori: Mauricio Salvo; Evelin González-Feliú; Jessica Toro; Iván Gallegos; Ignacio Maureira; Nicolás Miranda-González; Olga Barajas; Eva Bustamante; Monica Ahumada; Alicia Colombo; Ricardo Armisen; Camilo Villamán; Carolina Ibañez; María Loreto Bravo; Verónica Sanhueza; M. Loreto Spencer; Gonzalo de Toro; Erik Morales; Carolina Bizama; Patricia García; Ana María Carrasco; Lorena Gutiérrez; Ju
Pubblicato in: Journal of Personlized Medicine, Numero 2, 2021, ISSN 2075-4426
Editore: MDPI
DOI: 10.3390/jpm11090899

Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression

Autori: Alice Blandino, Dominique Scherer, Trine B. Rounge, Sinan U. Umu, Felix Boekstegers, Carol Barahona Ponce, Katherine Marcelain, Valentina Gárate-Calderón, Melanie Waldenberger, Erik Morales, Armando Rojas, César Munoz, Javier Retamales, Gonzalo de Toro, Olga Barajas, María Teresa Rivera, Analía Cortés, Denisse Loader, Javiera Saavedra, Lorena Gutiérrez, Alejandro Ortega, Maria Enriqueta Ber
Pubblicato in: Cancers, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030634

Cholecystectomy and digestive cancer in Chile: Complementary results from interrupted time series and aggregated data analyses

Autori: Constanza Gonzalez, Alfonso García‐Pérez, Bruno Nervi, César Munoz, Erik Morales, Hector Losada, Gina Merino‐Pereira, Francisco Rothhammer, Justo Lorenzo Bermejo
Pubblicato in: International Journal of Cancer, Numero 156, 2024, Pagina/e 91-103, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.35138

Risk of Gynecological Cancers in Cholecystectomized Women: A Large Nationwide Cohort Study

Autori: Elham Kharazmi, Kristina Sundquist, Jan Sundquist, Mahdi Fallah, Justo Lorenzo Bermejo
Pubblicato in: Cancers, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061484

Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer

Autori: Johannes Brägelmann, Carol Barahona Ponce, Katherine Marcelain, Stephanie Roessler, Benjamin Goeppert, Ivan Gallegos, Alicia Colombo, Verónica Sanhueza, Erik Morales, María Teresa Rivera, Gonzalo de Toro, Alejandro Ortega, Bettina Müller, Fernando Gabler, Dominique Scherer, Melanie Waldenberger, Eva Reischl, Felix Boekstegers, Valentina Garate-Calderon, Sinan U. Umu, Trine B. Rounge, Odilia Po
Pubblicato in: Hepatology, 2021, ISSN 1527-3350
Editore: AASLD
DOI: 10.1002/hep.31585

Development of an Application for Electronic Retrieval of Patient and Sample Information in Latin American Regions with a High Incidence of Gallbladder Cancer

Autori: Sergio Guinez-Molinos, Jaime Gonzalez Diaz, Carol Barahona Ponce andJusto Lorenzo Bermejo
Pubblicato in: Journal of Personalized Medicine, 2022, ISSN 2075-4426
Editore: MDPI
DOI: 10.3390/jpm12091476

Non-peer reviewed articles (2)

Reply

Autori: Dominique Scherer, Felix Boekstegers, Justo Lorenzo Bermejo
Pubblicato in: Gastroenterology, Numero 165, 2024, Pagina/e 1306-1307, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2023.08.018

International collaborative research to improve gallbladder cancer prevention

Autori: Dominique Scherer, Rajiv Kumar, Justo Lorenzo Bermejo, null null, Carol Barahona Ponce, Claudio Mengoa, Paola Montenegro, Albert Torres, Cristian Pacheco, Hector Losada, Ana Lineth Garcia, Sidney Rojas Orellana, Armando Rojas, Erik Morales, César Muñoz-Castro, Gonzalo de Toro, Allan Vera Kortmann, Loreto Spencer, Fabrizio Moisán, Cristian Lindner, Alejandro Ortega, Karina Vargas Valdebenito, Br
Pubblicato in: Nature Reviews Gastroenterology & Hepatology, Numero 22, 2025, Pagina/e 293-294, ISSN 1759-5045
Editore: Nature Publishing Group
DOI: 10.1038/s41575-025-01061-z