Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity

Risultati finali

1st animation

First animation video showing highlights of the project results

2nd animation

Second animation video showing highlights of the project results

Launch of Website, logo and flyer

Set of test compounds

Final list of the set of chemicals tested in WP2 and WP3.

Pubblicazioni

A human stem cell-derived test system for agents modifying neuronal N -methyl- d -aspartate-type glutamate receptor Ca 2+ -signalling

Autori: Stefanie Klima; Markus Brüll; Anna-Sophie Spreng; Ilinca Suciu; Tjalda Falt; Jens Christian Schwamborn; Tanja Waldmann; Christiaan Karreman; Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 6, 2021, ISSN 1432-0738
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03024-0

Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study

Autori: Fatih Özel, Marlene Stratmann, Christian Lindh, Chris Gennings, Carl-Gustaf Bornehag, Joëlle Rüegg
Pubblicato in: Environment International, 2023, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108029

Human neuronal signaling and communication assays to assess functional neurotoxicity.

Autori: Dominik Loser; Jasmin Schaefer; Timm Danker; Clemens Möller; Markus Brüll; Ilinca Suciu; Anna-Katharina Ückert; Stefanie Klima; Marcel Leist; Udo Kraushaar
Pubblicato in: Archives of Toxicology, Numero 5, 2021, ISSN 1432-0738
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02956-3

https://www.altex.org/index.php/altex/article/view/1339

Autori: Alice Krebs, Tanja Waldmann, Martin F. Wilks, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Andrea Terron, Thomas Steger-Hartmann, Joelle Ruegg, Costanza Rovida, Emma Pedersen, Giorgia Pallocca, Mirjam Luijten, Sofia B. Leite, Stefan Kustermann, Hennicke Kamp, Julia Hoeng, Philip Hewitt, Matthias Herzler, Jan G. Hengstler, Tuula Heinonen, Thomas Hartung, Barry Hardy, Florian Gantner, Ellen
Pubblicato in: ALTEX, Numero 36(4), 2019, Pagina/e 682-699, ISSN 1868-596X
Editore: Springer-Verlag Gmb
DOI: 10.14573/altex.1909271

CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes

Autori: Christiaan Karreman
Pubblicato in: ALTEX, Numero 37(2), 2020, Pagina/e 332-336, ISSN 1868-596X
Editore: Springer-Verlag GmbH
DOI: 10.14573/altex.2003191

Organophosphate insecticides disturb neuronal network development and function via non-AChE mediated mechanisms

Autori: Lennart V.J. van Melis, Harm J. Heusinkveld, Celine Langendoen, Anouk Peters, Remco H.S. Westerink
Pubblicato in: NeuroToxicology, 2023, ISSN 0161-813X
Editore: Elsevier BV
DOI: 10.1016/j.neuro.2022.11.002

Endocrine Disrupting Chemicals and Hippocampal Development: The Role of Estrogen and Androgen Signalling

Autori: Diana-Ioana Lupu, Andrea Cediel Ulloa, Joëlle Rüegg
Pubblicato in: Neuroendocrinology, 2023, ISSN 0028-3835
Editore: S. Karger AG
DOI: 10.1159/000531669

LP-32 Comparative Transcriptomics in Developing Rat Hippocampus After Perinatal Exposure to Bisphenol F (BPF), Butylbenzylphthalate (BBzP), 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), Permethrin (PMT), Perfluorooctanesulfonic acid (PFOS), and Triphenylphosphate (TPHP)

Autori: W. Lichtensteiger, C. Bassetti-Gaille, H. Rehrauer, J. Félix, B. Linillos-Pradillo, H. Idrissi, L. Miguélez-Salas, L. Rancan, S.D. Paredes, M. De la Fuente, P. Leonards, J. Rüegg, J.A.F. Tresguerres, M. Schlumpf
Pubblicato in: Toxicology Letters, 2022, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2022.07.772

Association of per- and polyfluoroalkyl substances with thyroid homeostasis during pregnancy in the SELMA study

Autori: Arash Derakhshan, Andreas Kortenkamp, Huan Shu, Maarten A C Broeren, Christian H Lindh, Robin P Peeters, Carl-Gustaf Bornehag, Barbara Demeneix, Tim I M Korevaar
Pubblicato in: Environment International, 2022, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107420

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.

Autori: Dominik Loser; Dominik Loser; Karin Grillberger; Maria G. Hinojosa; Jonathan Blum; Yves Haufe; Timm Danker; Ylva Johansson; Clemens Möller; Annette Nicke; Susanne Hougaard Bennekou; Iain Gardner; Caroline Bauch; Paul Walker; Anna Forsby; Gerhard F. Ecker; Udo Kraushaar; Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 7, 2021, ISSN 1432-0738
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03168-z

Environmental influences on brain aging

Autori: Barbara A. Demeneix
Pubblicato in: Aging Brain,Volume 1, 2021, 100003, Numero 7, 2021, ISSN 2589-9589
Editore: Elsevier
DOI: 10.1016/j.nbas.2020.100003

Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

Autori: Alice Krebs
Pubblicato in: ALTEX, Numero 37(1), 2019, Pagina/e 155-163, ISSN 1868-596X
Editore: Springer -Verlag GmbH
DOI: 10.14573/altex.1912021

LP-33 Memory Function in Adult Rat Offspring Following Perinatal Exposure to Chemicals Affecting Gene Expression Patterns in Developing Hippocampus

Autori: M. Schlumpf, J. Félix, B. Linillos-Pradillo, H. Idrissi, L. Miguélez-Salas, L. Rancan, S.D. Paredes, M. De la Fuente, P. Leonards, J. Rüegg, J.A.F. Tresguerres, W. Lichtensteiger
Pubblicato in: Toxicology Letters, 2022, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2022.07.773

From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures

Autori: Nicolò Caporale, Michelle Leemans, Lina Birgersson, Pierre-Luc Germain, Cristina Cheroni, Gábor Borbély, Elin Engdahl, Christian Lindh, Raul Bardini Bressan, Francesca Cavallo, Nadav Even Chorev, Giuseppe Alessandro D’agostino, Steven M. Pollard, Marco Tullio Rigoli, Erika Tenderini, Alejandro Lopez Tobon, Sebastiano Trattaro, Flavia Troglio, Matteo Zanella, Åke Bergman, Pauliina Damdimopoul
Pubblicato in: Science, 2022, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abe8244

Epigenetics of methylmercury

Autori: Andrea Cediel-Ulloa, Sabrina Lindner, Joëlle Rüegg, Karin Broberg
Pubblicato in: NeuroToxicology, 2023, ISSN 0161-813X
Editore: Elsevier BV
DOI: 10.1016/j.neuro.2023.05.004

Association Between Intellectual Functioning and Autistic Traits in the General Population of Children

Autori: Maria Marinopoulou, Eva Billstedt, Catrin Wessman, Carl-Gustaf Bornehag, Maria Unenge Hallerbäck
Pubblicato in: Child Psychiatry and Human Development, 2023, ISSN 0009-398X
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10578-023-01562-5

Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

Autori: Cristina Cheroni; Cristina Cheroni; Nicolò Caporale; Nicolò Caporale; Giuseppe Testa; Giuseppe Testa
Pubblicato in: Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020), Numero 2, 2020, ISSN 2040-2392
Editore: BioMed Central
DOI: 10.1186/s13229-020-00370-1

Oxidative stress increases in liver of lactating rats after BPF-low-dose exposure: perinatal effects in the offspring

Autori: Beatriz Linillos-Pradillo, Lisa Rancan, Julio García Murias, Margret Schlumpf, Walter Lichtensteiger, J. A. F. Tresguerres, Elena Vara, Sergio D. Paredes
Pubblicato in: Scientific Reports, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-38434-w

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

Autori: Johannes Delp; Andrea Cediel-Ulloa; Andrea Cediel-Ulloa; Ilinca Suciu; Petra Kranaster; Barbara M.A. van Vugt-Lussenburg; Vesna Munic Kos; Wanda van der Stel; Giada Carta; Susanne Hougaard Bennekou; Paul Jennings; Bob van de Water; Anna Forsby; Anna Forsby; Marcel Leist
Pubblicato in: Delp , J , Cediel-Ulloa , A , Suciu , I , Kranaster , P , van Vugt-Lussenburg , B M , Munic Kos , V , van der Stel , W , Carta , G , Bennekou , S H , Jennings , P , van de Water , B , Forsby , A & Leist , M 2021 , ' Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors ' , Archives of Toxicology , vol. 95 , pp. 591–615 . https://doi.org/10.1007/s00204-020, Numero 5, 2021, ISSN 1432-0738
Editore: Springer
DOI: 10.1007/s00204-020-02970-5

DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study

Autori: Elin Engdahl, Katherine Svensson, Ping-I Daniel Lin, Ali Alavian-Ghavaninic, Christian Lindh, Joëlle Rüegg, Carl-Gustaf Bornehag
Pubblicato in: Environment International, Volume 156, November 2021, 106617, 2021, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106617

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons.

Autori: Dominik Loser; Maria G. Hinojosa; Jonathan Blum; Jasmin Schaefer; Markus Brüll; Ylva Johansson; Ilinca Suciu; Karin Grillberger; Timm Danker; Clemens Möller; Iain Gardner; Gerhard F. Ecker; Susanne Hougaard Bennekou; Anna Forsby; Udo Kraushaar; Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 1, 2021, ISSN 1432-0738
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03031-1

Identification of mitochondrial toxicants by combined in silico and in vitro studies : a structure-based view on the Adverse Outcome Pathway

Autori: Florentina Troger; Johannes Delp; Melina Funke; Wanda van der Stel; Claire Colas; Marcel Leist; Bob van de Water; Gerhard F. Ecker
Pubblicato in: Computational Toxicology, 14, Numero 8, 2020, ISSN 2468-1113
Editore: Elsevier
DOI: 10.1016/j.comtox.2020.100123

Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models

Autori: Michael Dietrich, Christina Hecker, Elodie Martin, Dominique Langui, Michael Gliem, Bruno Stankoff, Catherine Lubetzki, Joel Gruchot, Peter Göttle, Andrea Issberner, Milad Nasiri, Pamela Ramseier, Christian Beerli, Sarah Tisserand, Nicolau Beckmann, Derya Shimshek, Patrick Petzsch, David Akbar, Bodo Levkau, Holger Stark, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, Sven Günther Meuth, Marc B
Pubblicato in: Neurology Neuroimmunology Neuroinflammation, 2022, ISSN 2332-7812
Editore: American Academy of Neurology
DOI: 10.1212/nxi.0000000000001161

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

Autori: Nadine Dreser, Katrin Madjar, Anna-Katharina Holzer, Marion Kapitza, Christopher Scholz, Petra Kranaster, Simon Gutbier, Stefanie Klima, David Kolb, Christian Dietz, Timo Trefzer, Johannes Meisig, Christoph van Thriel, Margit Henry, Michael R. Berthold, Nils Blüthgen, Agapios Sachinidis, Jörg Rahnenführer, Jan G. Hengstler, Tanja Waldmann, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 94/1, 2020, Pagina/e 151-171, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-019-02612-5

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities

Autori: Karine Audouze, Elias Zgheib, Khaled Abass, Asma H. Baig, Isabel Forner-Piquer, Henrik Holbech, Dries Knapen, Pim E. G. Leonards, Diana I. Lupu, Saranya Palaniswamy, Arja Rautio, Maria Sapounidou, Olwenn V. Martin
Pubblicato in: Front. Toxicol, 2021, ISSN 2673-3080
Editore: Frontiers
DOI: 10.3389/ftox.2021.787017

Predicting Endocrine Disruption Using Conformal Prediction – A Prioritization Strategy to Identify Hazardous Chemicals with Confidence

Autori: Maria Sapounidou, Ulf Norinder, Patrik L. Andersson
Pubblicato in: Chemical Research in Toxicology, 2022, ISSN 0893-228X
Editore: American Chemical Society
DOI: 10.1021/acs.chemrestox.2c00267

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autori: Xenia Dolde; Christiaan Karreman; Marianne Wiechers; Stefan Schildknecht; Marcel Leist
Pubblicato in: International Journal of Molecular Sciences, Vol 22, Iss 10079, p 10079 (2021), Numero 9, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Methylmercury-induced DNA methylation—From epidemiological observations to experimental evidence

Autori: Andrea Cediel-Ulloa, Ximiao Yu, Maria Hinojosa, Ylva Johansson, Anna Forsby, Karin Broberg, Joëlle Rüegg
Pubblicato in: Frontiers in Genetics, 2022, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2022.993387

Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System

Autori: Davide Marangon, Nicolò Caporale, Marta Boccazzi, Maria P. Abbracchio, Giuseppe Testa, Davide Lecca
Pubblicato in: Frontiers in cellular neuroscience, 2021, ISSN 1662-5102
Editore: Frontiers Research Foundation
DOI: 10.3389/fncel.2021.748849

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Autori: Michelle Leemans, Stephan Couderq, Barbara Demeneix, Jean-Baptiste Fini
Pubblicato in: Frontiers in Endocrinology, Numero 10, 2019, ISSN 1664-2392
Editore: Frontiers
DOI: 10.3389/fendo.2019.00743

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

Autori: Diana Lupu, Patrik Andersson, Carl-Gustaf Bornehag, Barbara Demeneix, Ellen Fritsche, Chris Gennings, Walter Lichtensteiger, Marcel Leist, Pim E. G. Leonards, Anne-Louise Ponsonby, Martin Scholze, Giuseppe Testa, Jesus A. F. Tresguerres, Remco H. S. Westerink, Bernard Zalc, Joëlle Rüegg
Pubblicato in: International Journal of Molecular Sciences, Numero 21/11, 2020, Pagina/e 3978, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21113978

Evidence for Prenatal Exposure to Thyroid Disruptors and Adverse Effects on Brain Development

Autori: Barbara A. Demeneix
Pubblicato in: European Thyroid Journal, Numero 8/6, 2019, Pagina/e 283-292, ISSN 2235-0640
Editore: S. Karger AG
DOI: 10.1159/000504668

TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs

Autori: Jördis Klose, Julia Tigges, Stefan Masjosthusmann, Katharina Schmuck, Farina Bendt, Ulrike Hübenthal, Patrick Petzsch, Karl Köhrer, Katharina Koch, Ellen Fritsche
Pubblicato in: ALTEX, 2021, ISSN 1868-8551
Editore: Springer spectrum
DOI: 10.14573/altex.2007201

Handling deviating control values in concentration-response curves.

Autori: Franziska Kappenberg; Tim Brecklinghaus; Wiebke Albrecht; Jonathan Blum; Carola van der Wurp; Marcel Leist; Jan G. Hengstler; Jörg Rahnenführer
Pubblicato in: Archives of Toxicology, Numero 2, 2020, ISSN 1432-0738
Editore: Springer Verlag
DOI: 10.1007/s00204-020-02913-0

Culture of Rat Primary Cortical Cells for Microelectrode Array (MEA) Recordings to Screen for Acute and Developmental Neurotoxicity

Autori: Lora-Sophie Gerber, Lennart V J van Melis, Regina G D M van Kleef, Aart de Groot, Remco H S Westerink
Pubblicato in: Curr Protoc . 2021 Jun;1(6):e158, 2021, ISSN 2691-1299
Editore: Wiley
DOI: 10.1002/cpz1.158

Using Metrics of a Mixture Effect and Nutrition from an Observational Study for Consideration towards Causal Inference

Autori: Chris Gennings, Katherine Svensson, Alicja Wolk, Christian Lindh, Hannu Kiviranta, Carl-Gustaf Bornehag
Pubblicato in: International Journal of Environmental Research and Public Health, 2022, ISSN 1661-7827
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19042273

Impact of endocrine disrupting chemicals on neurodevelopment: the need for better testing strategies for endocrine disruption-induced developmental neurotoxicity

Autori: Andrea Cediel-Ulloa, Diana Loana Lupu, Ylva Johansson, Maria Hinojosa, Fatih Özel, Joëlle Rüegg
Pubblicato in: Expert Review of Endocrinology & Metabolism, 2022, ISSN 1744-6651
Editore: Future Drugs Ltd.
DOI: 10.1080/17446651.2022.2044788

Is WISC-IV Working Memory Index associated with ADHD symptoms in 7–8-year-olds?

Autori: Maria Marinopoulou, Maria Unenge Hallerbäck, Carl-Gustaf Bornehag, Eva Billstedt
Pubblicato in: Applied Neuropsychology: Child, 2023, ISSN 2162-2965
Editore: Taylor and Francis Inc.
DOI: 10.1080/21622965.2023.2176232

Monitoring recovery after CNS demyelination, a novel tool to de-risk pro-remyelinating strategies

Autori: Esther Henriet, Elodie M Martin, Pauline Jubin, Dominique Langui, Abdelkrim Mannioui, Bruno Stankoff, Catherine Lubetzki, Arseny Khakhalin, Bernard Zalc
Pubblicato in: Brain, 2023, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awad051

Low Dose of BPA Induces Liver Injury through Oxidative Stress, Inflammation and Apoptosis in Long–Evans Lactating Rats and Its Perinatal Effect on Female PND6 Offspring

Autori: Beatriz Linillos-Pradillo, Lisa Rancan, Sergio D. Paredes, Margret Schlumpf, Walter Lichtensteiger, Elena Vara, Jesús Á. F. Tresguerres
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054585

The sociability spectrum: evidence from reciprocal genetic copy number variations.

Autori: Alejandro López-Tobón; Alejandro López-Tobón; Sebastiano Trattaro; Sebastiano Trattaro; Giuseppe Testa; Giuseppe Testa
Pubblicato in: Molecular Autism, Vol 11, Iss 1, Pp 1-13 (2020), Numero 2, 2020, ISSN 2040-2392
Editore: BioMed Central
DOI: 10.1186/s13229-020-00347-0

Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation.

Autori: Johannes Meisig; Johannes Meisig; Nadine Dreser; Marion Kapitza; Margit Henry; Tamara Rotshteyn; Jörg Rahnenführer; Jan G. Hengstler; Agapios Sachinidis; Tanja Waldmann; Marcel Leist; Nils Blüthgen; Nils Blüthgen
Pubblicato in: Nucleic Acids Research, Numero 1, 2020, ISSN 1362-4962
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa1089

From Cohort to Cohort: A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data

Autori: Maria Sapounidou,Patrik L. Andersson ,Michelle Leemans, Jean-Baptiste Fini, Barbara Demeneix, Joëlle Rüegg, Carl-Gustaf Bornehag, Chris Gennings
Pubblicato in: Toxics, 2023, ISSN 2305-6304
Editore: Basel: MDPI AG, 2013-
DOI: 10.3390/toxics11040331

A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice

Autori: Michela Di Criscio, Jennifer Ekholm Lodahl, Antonios Stamatakis, Efthymia Kitraki, Ioannis Bakoyiannis, Anastasia Repouskou, Carl-Gustaf Bornehag, Chris Gennings, Diana Lupu, Joëlle Rüegg
Pubblicato in: Chemosphere, 2022, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.137633

Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis

Autori: Alejandro López-Tobón, Carlo Emanuele Villa, Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Paola Conforti, Raffaele Iennaco, Maria Lachgar, Marco Tullio Rigoli, Berta Marcó de la Cruz, Pietro Lo Riso, Erika Tenderini, Flavia Troglio, Marco De Simone, Isabel Liste-Noya, Giuseppe Macino, Massimiliano Pagani, Elena Cattaneo, Giuseppe Testa
Pubblicato in: Stem Cell Reports, Numero 13/5, 2019, Pagina/e 847-861, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2019.09.005

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

Autori: Markus Brüll
Pubblicato in: ALTEX, Numero 37(3), 2020, Pagina/e 409-428, ISSN 1868-596X
Editore: Springer-Verlag GmbH
DOI: 10.14573/altex.1911111

SOC-VI-03 Applicability of the murine neural progenitor C17.2 cell-line for assessment of developmental neurotoxicity induced by endocrine disruptors

Autori: A. Cediel-Ulloa, R. Awoga, X. Yu, A. Gliga, A. Forsby, J. Rüegg
Pubblicato in: Toxicology Letters, 2022, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/j.toxlet.2022.07.223

Myelin replacement triggered by single-cell demyelination in mouse cortex.

Autori: Nicolas Snaidero; Martina Schifferer; Aleksandra Mezydlo; Bernard Zalc; Martin Kerschensteiner; Thomas Misgeld; Thomas Misgeld
Pubblicato in: Nature Communications, Numero 8, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-18632-0

SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

Autori: Christiaan Karreman
Pubblicato in: ALTEX, Numero 36(3), 2019, Pagina/e 518-520, ISSN 1868-596X
Editore: Springer - Verlag GMB
DOI: 10.14573/altex.1906251

Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolution

Autori: Nicolò Caporale, Davide Castaldi, Marco Tullio Rigoli, Cristina Cheroni, Sebastiano Trattaro, Alessia Valenti, Matteo Bonfanti, Sarah Stucchi, Alejandro Lopez Tobon, Dario Ricca, Manuel Lessi, Martina Pezzali, Alessandro Vitriolo, Katharina T. Schmid, Matthias Heinig, Fabian J. Theis, Carlo Emanuele Villa, Giuseppe Testa
Pubblicato in: 2023
Editore: BioRxiv
DOI: 10.1101/2023.08.21.553507

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