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Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways

Objective

Endocrine disruptors (EDs) are defined as exogenous chemicals that alter functions of the endocrine system, thereby causing adverse health effects in an organism or its progeny. Historically, the field of ED research has focused on reproductive endocrinology and related hormones, which is reflected in the regulatory test methods assessing endocrine effects of xenobiotics. However, recent evidence links increased incidence of metabolic syndrome (a cluster of metabolic risk factors including abdominal obesity, dyslipidemia, elevated blood pressure, and elevated fasting glucose) to EDs, increasing the incidence of atherosclerosis and type 2 diabetes. Despite these findings, adequate testing methods for metabolic effects of EDs are lacking. The project “Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways” (EDCMET) brings together experts in various research fields, including systems toxicologists, experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills and ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. This proposal focuses on developing novel test methods and models to assess the metabolic effects of EDs. Combined in silico methods, in vitro and in vivo methods are developed with an emphasis on liver and adipose tissue and endocrine pathways related to their metabolism. In addition, epidemiological and field monitoring data is used to gain information regarding the exposure to chemicals and ED-related metabolic effects. The interdisciplinary approach and complementary expertise of the participants will identify novel mechanisms of action, and in collaboration with the European Commission Joint Research Centre (JRC) providing an interface between the programme and European regulatory agencies, novel validated test methods for regulatory purposes will be generated.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases/arteriosclerosis

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ITA-SUOMEN YLIOPISTO
Address
Yliopistonranta 1 E
70211 Kuopio
Finland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 065 432,50

Participants (10)

OULUN YLIOPISTO
Finland
EU contribution
€ 870 193,75
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
EUROSAFE
France
EU contribution
€ 299 187,50
Address
Parc D Activite De La Breteche Batiment B1
35760 Sant-gregoire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PAMGENE INTERNATIONAL BV
Netherlands
EU contribution
€ 398 000
Address
Wolvenhoek 10-12
5211 HH Den Haag
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 276 510
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 240 000
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 370 000
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 401 031,25
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 360 050
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
BUNDESINSTITUT FUER RISIKOBEWERTUNG
Germany
EU contribution
€ 420 000
Address
Max Dohrn Strasse 8-10
10589 Berlin
Activity type
Research Organisations
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 280 003,75
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments