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Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways

Objective

Endocrine disruptors (EDs) are defined as exogenous chemicals that alter functions of the endocrine system, thereby causing adverse health effects in an organism or its progeny. Historically, the field of ED research has focused on reproductive endocrinology and related hormones, which is reflected in the regulatory test methods assessing endocrine effects of xenobiotics. However, recent evidence links increased incidence of metabolic syndrome (a cluster of metabolic risk factors including abdominal obesity, dyslipidemia, elevated blood pressure, and elevated fasting glucose) to EDs, increasing the incidence of atherosclerosis and type 2 diabetes. Despite these findings, adequate testing methods for metabolic effects of EDs are lacking. The project “Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways” (EDCMET) brings together experts in various research fields, including systems toxicologists, experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills and ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. This proposal focuses on developing novel test methods and models to assess the metabolic effects of EDs. Combined in silico methods, in vitro and in vivo methods are developed with an emphasis on liver and adipose tissue and endocrine pathways related to their metabolism. In addition, epidemiological and field monitoring data is used to gain information regarding the exposure to chemicals and ED-related metabolic effects. The interdisciplinary approach and complementary expertise of the participants will identify novel mechanisms of action, and in collaboration with the European Commission Joint Research Centre (JRC) providing an interface between the programme and European regulatory agencies, novel validated test methods for regulatory purposes will be generated.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2018-Single-Stage-RTD

Coordinator

ITA-SUOMEN YLIOPISTO
Net EU contribution
€ 2 065 432,50
Address
Yliopistonranta 1 E
70211 Kuopio
Finland

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (10)

OULUN YLIOPISTO
Finland
Net EU contribution
€ 870 193,75
Address
Pentti Kaiteran Katu 1
90014 Oulu

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EUROSAFE
France
Net EU contribution
€ 299 187,50
Address
Parc D Activite De La Breteche Batiment B1
35760 Sant-gregoire

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bretagne Bretagne Ille-et-Vilaine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PAMGENE INTERNATIONAL BV
Netherlands
Net EU contribution
€ 398 000,00
Address
Wolvenhoek 10-12
5211 HH Den Haag

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noord-Brabant Noordoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Net EU contribution
€ 276 510,00
Address
Geschwister-scholl-platz
72074 Tuebingen

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERZITA KARLOVA
Czechia
Net EU contribution
€ 240 000,00
Address
Ovocny Trh 560/5
116 36 Praha 1

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Region
Praha Hlavní město Praha
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
WAGENINGEN UNIVERSITY
Netherlands
Net EU contribution
€ 370 000,00
Address
Droevendaalsesteeg 4
6708 PB Wageningen

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Region
Oost-Nederland Gelderland Veluwe
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF LEEDS
United Kingdom
Net EU contribution
€ 401 031,25
Address
Woodhouse Lane
LS2 9JT Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 360 050,00
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00
BUNDESINSTITUT FUER RISIKOBEWERTUNG
Germany
Net EU contribution
€ 420 000,00
Address
Max Dohrn Strasse 8-10
10589 Berlin

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Region
Berlin Berlin Berlin
Activity type
Research Organisations
Non-EU contribution
€ 0,00
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
Net EU contribution
€ 280 003,75
Address
Hogskoleringen 1
7491 Trondheim

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Region
Norge Trøndelag Trøndelag
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00