Deliverables
An initial press release will be prepared describing the overall goals and ambition of the project and announcing the start of the project. The press release will initially be published on the BfR webpage and will be distributed to all project partners for publication on their individual webpages.
Project brochureThe project brochure within this deliverable will be in folded leaflet format and contain important information similar to what is presented on the website, aimed at presentation of the project e.g. by distribution of the brochure at scientific meetings. An electronic version of the brochure will also be provided on the project website for download; BfR will provide the project partners with printed brochures as required.
Project website for internal access as well as for public accessA website for the project will be generated and made publicly available. The initial website for internal access will serve the purpose of internal data exchange and information (e.g. on scientific events, reporting deadlines, published papers, repository of previous deliverables and reports) and be protected by a password. The publicly available website will contain information on the project goals, partners, current activities and events, recent developments and scientific publications, as well as contact information for stakeholders. Due date: 3/6 and updates
Data management plan is finalised. Availability of the data management plan will guide how research data are to be handled both during the project, and after the project is completed.
A stakeholder workshop to present and discuss the results from the first project phase is organized. If possible, the workshop will take place at the BfR facilities in Berlin, Germany. Organization of the workshop involves compilation of the scientific program, invitation of stakeholders, as well as general conference organization aspects. Stakeholder feedback will be collected, reviewed and used for optimization of the project strategy. A workshop report will be prepared and published as mentioned in the description of deliverable 5.6.
A validated classification system linking ED exposure to adverse outcomeA report detailing the identification of omic-level features that can be used to classify common molecular actions of known ED chemicals. These feature sets will be used to predict novel actions of ED chemicals, a proportion of which will be experimentally validated.
WorkshopJoint meeting for incorporating EDCMET findings
A report detailing the fingerprinting of ED chemical action across a range of omiclevels These fingerprints will be used to predict novel actions biomarkers of ED chemical exposure or effect a proportion of which will be experimentally validated
Report of the Ethical ReviewFormation of External Scientific Advisory Board
Members of the External Scientific Advisory Board are appointed by the end of the first project month.
Report describing standardized protocols for in vivo testing of metabolic effects of EDsThe report will describe the recommended protocols for the main in vivo tests to detect harmful metabolic effects of EDs
Database of mitochondrial screening battery data using ED refset1Validated NR reporter gene assays
Report on testing for ED effects in vulnerable individuals
The report will summarize a protocol for testing metabolic effects of EDs in obese mice Furthermore we shall describe a protocol for testing the metabolic effects of in utero exposure to EDs
Report with potencies of ED reference chemicalsA report of new biomarkers for population studies
Associations of measured ED levels and systemic metabolism by using highthroughput serum nuclear magnetic resonance NMR spectroscopy platform will be made to find new biomarkers for population studies This task needs the information from in vitro and in vivo studies in WP3
A report of the levels of selected EDs and health outcomesThe report consists of the analyzed levels of selected EDs in the study cohorts and literature review about associations of the exposure levels of EDs and health outcomes
Database of expression analysis data of HepaRG treated cells using ED refset1List of relevant events and stakeholders of the project to be involved in further activities
A list of relevant stakeholders with potential interest in the content and achievements of EDCMET is prepared. Stakeholders are identified based on their role in the field (e.g. regulatory agencies, basic science instituted, industry (see also deliverable 5.10)) and publicly available sources such as scientific publications or conference programs. The list will comprise contact persons, email addresses, affiliations and basic information about background, interests and own previous engagement in the field. The list will be hosted by BfR and will be continuously updated throughout the project.
A report of study protocol for monitoring effects of exposure to EDs in cohort studiesPrinciples for the study protocol suitable for detecting associations of the health outcomes and exposure to ED related compounds during pregnancy and later in life
Report with the performance based rank-order of tested metabolic ED assaysReport with the performance based rankorder of tested metabolic ED assays
Detailed dissemination and communication planBased on the list of the identified stakeholders and their particular interests, a dissemination and communication plan will be established. This document will contain considerations on appropriate communication and dissemination tools (e.g. newsletter, announcement on the project website, and others) to be developed and implemented for further use in the project, in order to ensure optimal interaction with the stakeholders.
Database of NR-cofactor interaction assay battery data using ED refset1Database of NRcofactor interaction assay battery data using ED refset1
Publications
Author(s):
Sakhteman A, Ghosh A, Fortino V
Published in:
Bioinformatics, 2022, ISSN 1367-4811
Publisher:
Oxford University Press
DOI:
10.1093/bioinformatics/btac045
Author(s):
Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Published in:
European Journal of Nutrition, Issue 60/8, 2021, Page(s) 4541-4553, ISSN 1436-6207
Publisher:
Dr. Dietrich Steinkopff Verlag
DOI:
10.1007/s00394-021-02606-z
Author(s):
Jukka Hakkola; Janne Hukkanen; Mikko Karpale
Published in:
Cells, Vol 11, Iss 313, p 313 (2022), Issue 29, 2023, ISSN 2073-4409
Publisher:
MDPI
DOI:
10.3390/cells11030313
Author(s):
Iohanna Filippi; Natalia Bravo; Joan O. Grimalt; Mariana Butinof; Daniel Lerda; Ricardo A. Fernández; Sonia E. Muñoz; María V. Amé
Published in:
Environmental Science and Pollution Research, Issue 28, 2021, Page(s) 908-953, ISSN 1614-7499
Publisher:
Springer Science and Business Media LLC
DOI:
10.1007/s11356-021-14397-1
Author(s):
Kristin Fritsche; Andrea Ziková-Kloas; Philip Marx-Stoelting; Albert Braeuning
Published in:
International Journal of Molecular Sciences, Issue 25, 2023, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms24032686
Author(s):
Alejandro Díaz-Holguín, Azam Rashidian, Dirk Pijnenburg, Dr. Glaucio Monteiro Ferreira, Alzbeta Stefela, Dr. Miroslav Kaspar, Prof. Eva Kudova, Prof. Antti Poso, Rinie van Beuningen, Prof. Petr Pavek, Dr. Thales Kronenberger
Published in:
Chem Med Chem, 2022, ISSN 1860-7187
Publisher:
Wiley-VCH GmbH
DOI:
10.1002/cmdc.202200556
Author(s):
Oliver Robinson, Marc Chadeau Hyam, Ibrahim Karaman, Rui Climaco Pinto, Mika Ala-Korpela, Evangelos Handakas, Giovanni Fiorito, He Gao, Andy Heard, Marjo‐Riitta Jarvelin, Matthew Lewis, Raha Pazoki, Silvia Polidoro, Ioanna Tzoulaki, Matthias Wielscher, Paul Elliott, Paolo Vineis
Published in:
Aging Cell, Issue 19/6, 2020, ISSN 1474-9718
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/acel.13149
Author(s):
"""Smutny T, Hyrsova L, Braeuning A,
Ingelman-Sundberg M, Pavek P"""
Published in:
Archives of toxicology, Issue 95, 2020, Page(s) 11-25, ISSN 0340-5761
Publisher:
Springer Verlag
DOI:
10.1007/s00204-020-02916-x
Author(s):
Saranya Palaniswamy, Khaled Abass, Jaana Rysä, Jon Øyvind Odland, Joan O. Grimalt, Arja Rautio, Marjo-Riitta Järvelin
Published in:
Environment International, Issue 156, 2021, Page(s) 106766, ISSN 0160-4120
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2021.106766
Author(s):
Cartwright R, Franklin L, Tikkinen KAO, Kalliala I, Miotla P, Rechberger T, Offiah I, McMahon S, O'Reilly B, Lince S, Kluivers K, Post WM, Poelmans G, Palmer MR, Wessells H, Wong A, Kuh D, Kivimaki M, Kumari M, Mangino M, Spector T, Guggenheim JA, Lehne B, De Silva NMG, Evans DM, Lawlor D, Karhunen V, Männikkö M, Marczak M, Bennett PR, Khullar V, Järvelin M-R, Walley A.
Published in:
The Journal of urology, Issue 206, 2021, Page(s) 679-687, ISSN 0022-5347
Publisher:
Elsevier BV
DOI:
10.1097/ju.0000000000001822
Author(s):
Mikko Karpale, Aki Juhani Käräjämäki, Outi Kummu, Helena Gylling, Tuulia Hyötyläinen, Matej Orešič, Ari Tolonen, Heidi Hautajärvi, Markku J. Savolainen, Mika Ala‐Korpela, Janne Hukkanen, Jukka Hakkola
Published in:
British Journal of Pharmacology, Issue 178/12, 2021, Page(s) 2461-2481, ISSN 0007-1188
Publisher:
Wiley-Blackwell
DOI:
10.1111/bph.15433
Author(s):
Hukkanen J, Hakkola J
Published in:
Cells, Issue 9, 2020, Page(s) 2445, ISSN 2073-4409
Publisher:
MDPI
DOI:
10.3390/cells9112445
Author(s):
Oliver Robinson, Alice R Carter, Mika Ala-Korpela, Juan P Casas, Nishi Chaturvedi, Jorgen Engmann, Laura D Howe, Alun D Hughes, Marjo-Riitta Järvelin, Mika Kähönen, Ville Karhunen, Diana Kuh, Tina Shah, Yoav Ben-Shlomo, Reecha Sofat, Chung-Ho E Lau, Terho Lehtimäki, Usha Menon, Olli Raitakari, Andy Ryan, Rui Providencia, Stephanie Smith, Julie Taylor, Therese Tillin, Jorma Viikari, Andrew Wong
Published in:
International Journal of Epidemiology, Issue 50/3, 2020, Page(s) 768-782, ISSN 0300-5771
Publisher:
Oxford University Press
DOI:
10.1093/ije/dyaa188
Author(s):
Xu S, Hansen S, Rautio A, Järvelin M, Abass K, Rysä J, Palaniswamy S, Huber S, Grimalt JO, Dumas P, Odland JO
Published in:
Environmental Research, Issue 204, 2021, Page(s) 111980, ISSN 0013-9351
Publisher:
Academic Press
DOI:
10.1016/j.envres.2021.111980
Author(s):
Jenni Küblbeck, Jonna Niskanen, Paavo Honkakoski
Published in:
Cells, Issue 9/10, 2020, Page(s) 2306, ISSN 2073-4409
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cells9102306
Author(s):
Skoda J, Dohnalova K, Chalupsky K, Stahl A, Templin M, Maixnerova J, Micuda S, Grontved L, Braeuning A, Pavek P
Published in:
Biochemical pharmacology, Issue 197, 2022, Page(s) 114905-114905, ISSN 0006-2952
Publisher:
Elsevier BV
DOI:
10.1016/j.bcp.2021.114905
Author(s):
A. Sakhteman; M. Failli; J. Kublbeck; A.L. Levonen; V. Fortino
Published in:
Environment International, Issue 156, 2021, Page(s) 106751, ISSN 0160-4120
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2021.106751
Author(s):
Jenni Küblbeck, Taina Vuorio, Jonna Niskanen, Vittorio Fortino, Albert Braeuning, Khaled Abass, Arja Rautio, Jukka Hakkola, Paavo Honkakoski, Anna-Liisa Levonen
Published in:
International Journal of Molecular Sciences, Issue 21/8, 2020, Page(s) 3021, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21083021
Author(s):
Natalia Bravo, Joan O. Grimalt, Darja Mazej, Janja Snoj Tratnik, Dimosthenis Andreas Sarigiannis, Milena Horvat
Published in:
Environment International, Issue 134, 2020, Page(s) 105264, ISSN 0160-4120
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2019.105264
Author(s):
Eva Junqué, Sergi Garcia, María Ángeles Martínez, Joaquim Rovira, Marta Schuhmacher, Joan O. Grimalt
Published in:
Environmental Research, Issue 182, 2020, Page(s) 108994, ISSN 0013-9351
Publisher:
Academic Press
DOI:
10.1016/j.envres.2019.108994
Author(s):
Eva Junqué, Joan O. Grimalt, Ana Fernández-Somoano, Adonina Tardón
Published in:
Environmental Research, Issue 183, 2020, Page(s) 109147, ISSN 0013-9351
Publisher:
Academic Press
DOI:
10.1016/j.envres.2020.109147
Author(s):
Natalia Bravo, Joan O. Grimalt, Max Chashchin, Valery P. Chashchin, Jon-Øyvind Odland
Published in:
Environment International, Issue 124, 2019, Page(s) 541-552, ISSN 0160-4120
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2019.01.049
Author(s):
Mercè Garí, Joan O. Grimalt, Esther Vizcaino, Adonina Tardón, Ana Fernández-Somoano
Published in:
Environment International, Issue 133, 2019, Page(s) 105241, ISSN 0160-4120
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2019.105241
Author(s):
Natalia Bravo, Soraya Peralta, Joan O. Grimalt, Maria Ángeles Martínez, Joaquim Rovira, Marta Schuhmacher
Published in:
Environmental Research, Issue 182, 2020, Page(s) 109003, ISSN 0013-9351
Publisher:
Academic Press
DOI:
10.1016/j.envres.2019.109003
Author(s):
Brecht Attema; Aafke W.F. Janssen; Deborah Rijkers; Evert M. van Schothorst; Guido J.E.J. Hooiveld; Sander Kersten
Published in:
Molecular Metabolism, Issue 7, 2022, ISSN 2212-8778
Publisher:
Elsevier GmbH
DOI:
10.1016/j.molmet.2022.101602
Author(s):
Barend L. van Drooge; Ioar Rivas; Xavier Querol; Jordi Sunyer; Joan O. Grimalt
Published in:
International Journal of Environmental Research and Public Health, Issue 17, 2020, Page(s) 3685, ISSN 1660-4601
Publisher:
MDPI
DOI:
10.3390/ijerph17103685
Author(s):
Karine Audouze; Elias Zgheib; Khaled Abass; Khaled Abass; Asma H. Baig; Isabel Forner-Piquer; Henrik Holbech; Dries Knapen; Pim E. G. Leonards; Diana I. Lupu; Saranya Palaniswamy; Arja Rautio; Maria Sapounidou; Olwenn V. Martin
Published in:
Frontiers in Toxicology, Issue 3, 2021, ISSN 2673-3080
Publisher:
Frontiers Media S.A
DOI:
10.3389/ftox.2021.787017
Author(s):
Khaled Abass; Olavi Pelkonen; Arja Rautio
Published in:
Current Drug Metabolism, Issue 22, 2022, Page(s) 645-656, ISSN 1389-2002
Publisher:
Bentham Science Publishers
DOI:
10.2174/1389200222666210701164945
Author(s):
Beaumont, R. N., Kotecha, S. J., Wood, A. R., Knight, B. A., Sebert, S., McCarthy, M. I., Hattersley, A. T., Järvelin, M. R., Timpson, N. J., Freathy, R. M., & Kotecha, S.
Published in:
PLoS genetics, Issue 16, 2020, Page(s) e1009191-e1009191, ISSN 1553-7390
Publisher:
Public Library of Science
DOI:
10.1371/journal.pgen.1009191
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