Rezultaty
An initial press release will be prepared describing the overall goals and ambition of the project and announcing the start of the project. The press release will initially be published on the BfR webpage and will be distributed to all project partners for publication on their individual webpages.
Project brochureThe project brochure within this deliverable will be in folded leaflet format and contain important information similar to what is presented on the website, aimed at presentation of the project e.g. by distribution of the brochure at scientific meetings. An electronic version of the brochure will also be provided on the project website for download; BfR will provide the project partners with printed brochures as required.
Project website for internal access as well as for public accessA website for the project will be generated and made publicly available. The initial website for internal access will serve the purpose of internal data exchange and information (e.g. on scientific events, reporting deadlines, published papers, repository of previous deliverables and reports) and be protected by a password. The publicly available website will contain information on the project goals, partners, current activities and events, recent developments and scientific publications, as well as contact information for stakeholders. Due date: 3/6 and updates
Data management plan is finalised. Availability of the data management plan will guide how research data are to be handled both during the project, and after the project is completed.
A stakeholder workshop to present and discuss the results from the first project phase is organized. If possible, the workshop will take place at the BfR facilities in Berlin, Germany. Organization of the workshop involves compilation of the scientific program, invitation of stakeholders, as well as general conference organization aspects. Stakeholder feedback will be collected, reviewed and used for optimization of the project strategy. A workshop report will be prepared and published as mentioned in the description of deliverable 5.6.
A validated classification system linking ED exposure to adverse outcomeA report detailing the identification of omic-level features that can be used to classify common molecular actions of known ED chemicals. These feature sets will be used to predict novel actions of ED chemicals, a proportion of which will be experimentally validated.
WorkshopJoint meeting for incorporating EDCMET findings
A report detailing the fingerprinting of ED chemical action across a range of omiclevels These fingerprints will be used to predict novel actions biomarkers of ED chemical exposure or effect a proportion of which will be experimentally validated
Report of the Ethical ReviewFormation of External Scientific Advisory Board
Members of the External Scientific Advisory Board are appointed by the end of the first project month.
Report describing standardized protocols for in vivo testing of metabolic effects of EDsThe report will describe the recommended protocols for the main in vivo tests to detect harmful metabolic effects of EDs
Database of mitochondrial screening battery data using ED refset1Validated NR reporter gene assays
Report on testing for ED effects in vulnerable individuals
The report will summarize a protocol for testing metabolic effects of EDs in obese mice Furthermore we shall describe a protocol for testing the metabolic effects of in utero exposure to EDs
Report with potencies of ED reference chemicalsA report of new biomarkers for population studies
Associations of measured ED levels and systemic metabolism by using highthroughput serum nuclear magnetic resonance NMR spectroscopy platform will be made to find new biomarkers for population studies This task needs the information from in vitro and in vivo studies in WP3
A report of the levels of selected EDs and health outcomesThe report consists of the analyzed levels of selected EDs in the study cohorts and literature review about associations of the exposure levels of EDs and health outcomes
Database of expression analysis data of HepaRG treated cells using ED refset1List of relevant events and stakeholders of the project to be involved in further activities
A list of relevant stakeholders with potential interest in the content and achievements of EDCMET is prepared. Stakeholders are identified based on their role in the field (e.g. regulatory agencies, basic science instituted, industry (see also deliverable 5.10)) and publicly available sources such as scientific publications or conference programs. The list will comprise contact persons, email addresses, affiliations and basic information about background, interests and own previous engagement in the field. The list will be hosted by BfR and will be continuously updated throughout the project.
A report of study protocol for monitoring effects of exposure to EDs in cohort studiesPrinciples for the study protocol suitable for detecting associations of the health outcomes and exposure to ED related compounds during pregnancy and later in life
Report with the performance based rank-order of tested metabolic ED assaysReport with the performance based rankorder of tested metabolic ED assays
Detailed dissemination and communication planBased on the list of the identified stakeholders and their particular interests, a dissemination and communication plan will be established. This document will contain considerations on appropriate communication and dissemination tools (e.g. newsletter, announcement on the project website, and others) to be developed and implemented for further use in the project, in order to ensure optimal interaction with the stakeholders.
Database of NR-cofactor interaction assay battery data using ED refset1Database of NRcofactor interaction assay battery data using ED refset1
Publikacje
Autorzy:
Sakhteman A, Ghosh A, Fortino V
Opublikowane w:
Bioinformatics, 2022, ISSN 1367-4811
Wydawca:
Oxford University Press
DOI:
10.1093/bioinformatics/btac045
Autorzy:
Helmi Ikonen, Johanna Lumme, Jussi Seppälä, Paula Pesonen, Terhi Piltonen, Marjo-Riitta Järvelin, Karl-Heinz Herzig, Jouko Miettunen, Maarit Niinimäki, Saranya Palaniswamy, Sylvain Sebert, Marja Ojaniemi
Opublikowane w:
European Journal of Nutrition, Numer 60/8, 2021, Strona(/y) 4541-4553, ISSN 1436-6207
Wydawca:
Dr. Dietrich Steinkopff Verlag
DOI:
10.1007/s00394-021-02606-z
Autorzy:
Jukka Hakkola; Janne Hukkanen; Mikko Karpale
Opublikowane w:
Cells, Vol 11, Iss 313, p 313 (2022), Numer 29, 2023, ISSN 2073-4409
Wydawca:
MDPI
DOI:
10.3390/cells11030313
Autorzy:
Iohanna Filippi; Natalia Bravo; Joan O. Grimalt; Mariana Butinof; Daniel Lerda; Ricardo A. Fernández; Sonia E. Muñoz; María V. Amé
Opublikowane w:
Environmental Science and Pollution Research, Numer 28, 2021, Strona(/y) 908-953, ISSN 1614-7499
Wydawca:
Springer Science and Business Media LLC
DOI:
10.1007/s11356-021-14397-1
Autorzy:
Kristin Fritsche; Andrea Ziková-Kloas; Philip Marx-Stoelting; Albert Braeuning
Opublikowane w:
International Journal of Molecular Sciences, Numer 25, 2023, ISSN 1422-0067
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms24032686
Autorzy:
Alejandro Díaz-Holguín, Azam Rashidian, Dirk Pijnenburg, Dr. Glaucio Monteiro Ferreira, Alzbeta Stefela, Dr. Miroslav Kaspar, Prof. Eva Kudova, Prof. Antti Poso, Rinie van Beuningen, Prof. Petr Pavek, Dr. Thales Kronenberger
Opublikowane w:
Chem Med Chem, 2022, ISSN 1860-7187
Wydawca:
Wiley-VCH GmbH
DOI:
10.1002/cmdc.202200556
Autorzy:
Oliver Robinson, Marc Chadeau Hyam, Ibrahim Karaman, Rui Climaco Pinto, Mika Ala-Korpela, Evangelos Handakas, Giovanni Fiorito, He Gao, Andy Heard, Marjo‐Riitta Jarvelin, Matthew Lewis, Raha Pazoki, Silvia Polidoro, Ioanna Tzoulaki, Matthias Wielscher, Paul Elliott, Paolo Vineis
Opublikowane w:
Aging Cell, Numer 19/6, 2020, ISSN 1474-9718
Wydawca:
Blackwell Publishing Inc.
DOI:
10.1111/acel.13149
Autorzy:
"""Smutny T, Hyrsova L, Braeuning A,
Ingelman-Sundberg M, Pavek P"""
Opublikowane w:
Archives of toxicology, Numer 95, 2020, Strona(/y) 11-25, ISSN 0340-5761
Wydawca:
Springer Verlag
DOI:
10.1007/s00204-020-02916-x
Autorzy:
Saranya Palaniswamy, Khaled Abass, Jaana Rysä, Jon Øyvind Odland, Joan O. Grimalt, Arja Rautio, Marjo-Riitta Järvelin
Opublikowane w:
Environment International, Numer 156, 2021, Strona(/y) 106766, ISSN 0160-4120
Wydawca:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2021.106766
Autorzy:
Cartwright R, Franklin L, Tikkinen KAO, Kalliala I, Miotla P, Rechberger T, Offiah I, McMahon S, O'Reilly B, Lince S, Kluivers K, Post WM, Poelmans G, Palmer MR, Wessells H, Wong A, Kuh D, Kivimaki M, Kumari M, Mangino M, Spector T, Guggenheim JA, Lehne B, De Silva NMG, Evans DM, Lawlor D, Karhunen V, Männikkö M, Marczak M, Bennett PR, Khullar V, Järvelin M-R, Walley A.
Opublikowane w:
The Journal of urology, Numer 206, 2021, Strona(/y) 679-687, ISSN 0022-5347
Wydawca:
Elsevier BV
DOI:
10.1097/ju.0000000000001822
Autorzy:
Mikko Karpale, Aki Juhani Käräjämäki, Outi Kummu, Helena Gylling, Tuulia Hyötyläinen, Matej Orešič, Ari Tolonen, Heidi Hautajärvi, Markku J. Savolainen, Mika Ala‐Korpela, Janne Hukkanen, Jukka Hakkola
Opublikowane w:
British Journal of Pharmacology, Numer 178/12, 2021, Strona(/y) 2461-2481, ISSN 0007-1188
Wydawca:
Wiley-Blackwell
DOI:
10.1111/bph.15433
Autorzy:
Hukkanen J, Hakkola J
Opublikowane w:
Cells, Numer 9, 2020, Strona(/y) 2445, ISSN 2073-4409
Wydawca:
MDPI
DOI:
10.3390/cells9112445
Autorzy:
Oliver Robinson, Alice R Carter, Mika Ala-Korpela, Juan P Casas, Nishi Chaturvedi, Jorgen Engmann, Laura D Howe, Alun D Hughes, Marjo-Riitta Järvelin, Mika Kähönen, Ville Karhunen, Diana Kuh, Tina Shah, Yoav Ben-Shlomo, Reecha Sofat, Chung-Ho E Lau, Terho Lehtimäki, Usha Menon, Olli Raitakari, Andy Ryan, Rui Providencia, Stephanie Smith, Julie Taylor, Therese Tillin, Jorma Viikari, Andrew Wong
Opublikowane w:
International Journal of Epidemiology, Numer 50/3, 2020, Strona(/y) 768-782, ISSN 0300-5771
Wydawca:
Oxford University Press
DOI:
10.1093/ije/dyaa188
Autorzy:
Xu S, Hansen S, Rautio A, Järvelin M, Abass K, Rysä J, Palaniswamy S, Huber S, Grimalt JO, Dumas P, Odland JO
Opublikowane w:
Environmental Research, Numer 204, 2021, Strona(/y) 111980, ISSN 0013-9351
Wydawca:
Academic Press
DOI:
10.1016/j.envres.2021.111980
Autorzy:
Jenni Küblbeck, Jonna Niskanen, Paavo Honkakoski
Opublikowane w:
Cells, Numer 9/10, 2020, Strona(/y) 2306, ISSN 2073-4409
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/cells9102306
Autorzy:
Skoda J, Dohnalova K, Chalupsky K, Stahl A, Templin M, Maixnerova J, Micuda S, Grontved L, Braeuning A, Pavek P
Opublikowane w:
Biochemical pharmacology, Numer 197, 2022, Strona(/y) 114905-114905, ISSN 0006-2952
Wydawca:
Elsevier BV
DOI:
10.1016/j.bcp.2021.114905
Autorzy:
A. Sakhteman; M. Failli; J. Kublbeck; A.L. Levonen; V. Fortino
Opublikowane w:
Environment International, Numer 156, 2021, Strona(/y) 106751, ISSN 0160-4120
Wydawca:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2021.106751
Autorzy:
Jenni Küblbeck, Taina Vuorio, Jonna Niskanen, Vittorio Fortino, Albert Braeuning, Khaled Abass, Arja Rautio, Jukka Hakkola, Paavo Honkakoski, Anna-Liisa Levonen
Opublikowane w:
International Journal of Molecular Sciences, Numer 21/8, 2020, Strona(/y) 3021, ISSN 1422-0067
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21083021
Autorzy:
Natalia Bravo, Joan O. Grimalt, Darja Mazej, Janja Snoj Tratnik, Dimosthenis Andreas Sarigiannis, Milena Horvat
Opublikowane w:
Environment International, Numer 134, 2020, Strona(/y) 105264, ISSN 0160-4120
Wydawca:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2019.105264
Autorzy:
Eva Junqué, Sergi Garcia, María Ángeles Martínez, Joaquim Rovira, Marta Schuhmacher, Joan O. Grimalt
Opublikowane w:
Environmental Research, Numer 182, 2020, Strona(/y) 108994, ISSN 0013-9351
Wydawca:
Academic Press
DOI:
10.1016/j.envres.2019.108994
Autorzy:
Eva Junqué, Joan O. Grimalt, Ana Fernández-Somoano, Adonina Tardón
Opublikowane w:
Environmental Research, Numer 183, 2020, Strona(/y) 109147, ISSN 0013-9351
Wydawca:
Academic Press
DOI:
10.1016/j.envres.2020.109147
Autorzy:
Natalia Bravo, Joan O. Grimalt, Max Chashchin, Valery P. Chashchin, Jon-Øyvind Odland
Opublikowane w:
Environment International, Numer 124, 2019, Strona(/y) 541-552, ISSN 0160-4120
Wydawca:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2019.01.049
Autorzy:
Mercè Garí, Joan O. Grimalt, Esther Vizcaino, Adonina Tardón, Ana Fernández-Somoano
Opublikowane w:
Environment International, Numer 133, 2019, Strona(/y) 105241, ISSN 0160-4120
Wydawca:
Pergamon Press Ltd.
DOI:
10.1016/j.envint.2019.105241
Autorzy:
Natalia Bravo, Soraya Peralta, Joan O. Grimalt, Maria Ángeles Martínez, Joaquim Rovira, Marta Schuhmacher
Opublikowane w:
Environmental Research, Numer 182, 2020, Strona(/y) 109003, ISSN 0013-9351
Wydawca:
Academic Press
DOI:
10.1016/j.envres.2019.109003
Autorzy:
Brecht Attema; Aafke W.F. Janssen; Deborah Rijkers; Evert M. van Schothorst; Guido J.E.J. Hooiveld; Sander Kersten
Opublikowane w:
Molecular Metabolism, Numer 7, 2022, ISSN 2212-8778
Wydawca:
Elsevier GmbH
DOI:
10.1016/j.molmet.2022.101602
Autorzy:
Barend L. van Drooge; Ioar Rivas; Xavier Querol; Jordi Sunyer; Joan O. Grimalt
Opublikowane w:
International Journal of Environmental Research and Public Health, Numer 17, 2020, Strona(/y) 3685, ISSN 1660-4601
Wydawca:
MDPI
DOI:
10.3390/ijerph17103685
Autorzy:
Karine Audouze; Elias Zgheib; Khaled Abass; Khaled Abass; Asma H. Baig; Isabel Forner-Piquer; Henrik Holbech; Dries Knapen; Pim E. G. Leonards; Diana I. Lupu; Saranya Palaniswamy; Arja Rautio; Maria Sapounidou; Olwenn V. Martin
Opublikowane w:
Frontiers in Toxicology, Numer 3, 2021, ISSN 2673-3080
Wydawca:
Frontiers Media S.A
DOI:
10.3389/ftox.2021.787017
Autorzy:
Khaled Abass; Olavi Pelkonen; Arja Rautio
Opublikowane w:
Current Drug Metabolism, Numer 22, 2022, Strona(/y) 645-656, ISSN 1389-2002
Wydawca:
Bentham Science Publishers
DOI:
10.2174/1389200222666210701164945
Autorzy:
Beaumont, R. N., Kotecha, S. J., Wood, A. R., Knight, B. A., Sebert, S., McCarthy, M. I., Hattersley, A. T., Järvelin, M. R., Timpson, N. J., Freathy, R. M., & Kotecha, S.
Opublikowane w:
PLoS genetics, Numer 16, 2020, Strona(/y) e1009191-e1009191, ISSN 1553-7390
Wydawca:
Public Library of Science
DOI:
10.1371/journal.pgen.1009191
Wyszukiwanie danych OpenAIRE...
Podczas wyszukiwania danych OpenAIRE wystąpił błąd
Brak wyników