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Unlocking Precision Gene Therapy

Project description

Advanced gene-editing tools for safer gene therapy

Gene therapy offers a promising approach to treat incurable diseases by silencing, activating or recoding specific genes. In addition to conventional gene transfer strategies, newly emerged gene-editing technologies provide the potential for precise manipulation of the genome. The EU-funded UPGRADE project aims to address certain gene therapy limitations associated with insertional mutagenesis, off-target effects, or limited efficiency. Researchers will develop disruptive new technologies for precision gene and epigenome editing, as well as for gene insertion. Following stringent validation, the project will lead to advanced medicinal products and versatile tools that could be used for a number of diseases.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2018-Single-Stage-RTD

Coordinator

FONDAZIONE TELETHON ETS
Net EU contribution
€ 3 412 968,75
Address
Via Varese 16/b
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (10)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

OSPEDALE SAN RAFFAELE SRL
Italy
Net EU contribution
€ 1 365 625,00
Address
Via Olgettina 60
20132 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INNOVAVECTOR SRL
Italy
Net EU contribution
€ 110 000,00
Address
Via Campi Flegrei 34
80078 Pozzuoli

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Sud Campania Napoli
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

NEXT GENERATION DIAGNOSTIC SRL
Italy
Net EU contribution
€ 64 375,00
Address
Via Campi Flegrei 34
80078 Pozzuoli

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Sud Campania Napoli
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSIDAD POMPEU FABRA
Spain
Net EU contribution
€ 2 767 377,50
Address
Placa De La Merce, 10-12
08002 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI TRENTO
Italy
Net EU contribution
€ 1 333 798,75
Address
Via Calepina 14
38122 Trento

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Region
Nord-Est Provincia Autonoma di Trento Trento
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNISCHE UNIVERSITAET DRESDEN
Germany
Net EU contribution
€ 1 107 000,00
Address
Helmholtzstrasse 10
01069 Dresden

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Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
VRIJE UNIVERSITEIT BRUSSEL
Belgium
Net EU contribution
€ 1 328 412,50
Address
Pleinlaan 2
1050 Brussel

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NANTES UNIVERSITE
France
Net EU contribution
€ 1 182 500,00
Address
1 Quai De Tourville
44000 Nantes

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Region
Pays de la Loire Pays de la Loire Loire-Atlantique
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 1 106 062,50
Address
Geschwister Scholl Platz 1
80539 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 1 125,00
THE GENERAL HOSPITAL CORPORATION
United States
Net EU contribution
€ 1 217 710,00
Non-EU contribution
€ 0,00