Project description
Advanced gene-editing tools for safer gene therapy
Gene therapy offers a promising approach to treat incurable diseases by silencing, activating or recoding specific genes. In addition to conventional gene transfer strategies, newly emerged gene-editing technologies provide the potential for precise manipulation of the genome. The EU-funded UPGRADE project aims to address certain gene therapy limitations associated with insertional mutagenesis, off-target effects, or limited efficiency. Researchers will develop disruptive new technologies for precision gene and epigenome editing, as well as for gene insertion. Following stringent validation, the project will lead to advanced medicinal products and versatile tools that could be used for a number of diseases.
Fields of science
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesclinical medicineophthalmology
- medical and health sciencesclinical medicinehematology
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
00185 Roma
Italy
See on map
Participants (10)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
20132 Milano
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
80078 Pozzuoli
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
80078 Pozzuoli
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
08002 Barcelona
See on map
38122 Trento
See on map
01069 Dresden
See on map
1050 Brussel
See on map
44000 Nantes
See on map
80539 Muenchen
See on map
02114 Boston Ma
See on map