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Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients with Bone Metastasis

Objective

Bone metastases are a common manifestation of advanced cancer, with pain as a devastating consequence. Due to rising cancer incidence rates and improving survival, the number of cancer patients living long enough to develop bone metastases is increasing rapidly. Metastatic bone pain is difficult to manage and has a detrimental impact on quality of life of patients, their partners and care-givers.

Radiation therapy (RT), the standard treatment for palliation of metastatic bone pain, is easy to administer and well tolerated. However, RT is only effective in 60-70% of patients and usually takes four weeks before inducing pain response. Inadequate pain relief is therefore common and alternative treatment options are urgently needed.

Pain palliation may be substantially improved by including MR-HIFU as alternative or in addition to RT. Preliminary studies suggest that MR-HIFU induces rapid pain relief (within days), and may palliate pain in patients in whom RT is not effective. Currently, strong evidence and context is lacking for wide-spread implementation of MR-HIFU into routine care.

The FURTHER project aims to demonstrate (cost)effectiveness of MR-HIFU as an alternative or additional treatment option to relief metastatic bone pain. For this purpose, a three arm international randomized controlled trial (RCT) including 216 patients will be conducted comparing early and late pain response in patients treated with RT only, MR-HIFU only, and RT with MR-HIFU. A prediction model will be developed to identify patients who are likely to benefit from MR-HIFU in order to allow (cost-) effective use of the treatment. A pilot pathway RCT will be conducted to explore the effectiveness of MR-HIFU as part of a comprehensive pain management strategy. Finally, FURTHER will map and analyse socio-economic barriers for integration of MR-HIFU in routine care in the wider European context and make recommendations on how to provide equal access to this promising new treatment.

Field of science

  • /natural sciences/physical sciences/acoustics/ultrasound
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 971 312,50

Participants (9)

VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 430 250
Address
Kiinamyllynkatu 4-8
20520 Turku
Activity type
Research Organisations
STICHTING ISALA KLINIEKEN
Netherlands
EU contribution
€ 386 250
Address
Dokter Van Heesweg 2
8025 AB Zwolle
Activity type
Other
CENTRO SA.NA. SERVIZI SANITARI PRIVATI SRL
Italy
EU contribution
€ 260 625
Address
Via Peschiera Snc
04011 Aprilia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 646 415
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 158 750
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
ISTITUTO ORTOPEDICO RIZZOLI
Italy
EU contribution
€ 280 835
Address
Via Di Barbiano 1/10
40136 Bologna
Activity type
Research Organisations
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 107 495
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
EU contribution
€ 756 192,50
Address
Old Brompton Road 123
SW7 3RP London
Activity type
Higher or Secondary Education Establishments
FOCUSED ULTRASOUND FOUNDATION
United States
EU contribution
€ 0
Address
Cedars Court
22903 Charlottesville
Activity type
Other