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''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals

Project description

Development of universal drug to target viral co-infection in the nervous system

Zika, dengue, chikungunya, HIV and measles claim thousands of victims each year. These viral infections of the central nervous system cause neurological impairment. Zika, dengue and chikungunya viruses are spread mainly by mosquitoes of the Aedes genus. Zika virus can get through the blood-placental barrier and then the developing blood-brain barrier of the foetus, causing newborn microcephaly and neurological disorders. Current drug development strategies completely overlook the reality of co-infection for these viruses. The EU-funded NOVIRUSES2BRAIN project will identify and select universal drug candidates that translocate blood-placental and blood-brain barriers to target these viruses, even during pregnancy. This project has international scope, including experts in medicinal chemistry, biochemistry, virology and drug development. NOVIRUSES2BRAIN aims to create a drug that clears all viral species from the brain simultaneously.

Field of science

  • /natural sciences/biological sciences/microbiology/virology
  • /medical and health sciences/health sciences/infectious disease/RNA virus

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Address
Avenida Prof Egas Moniz
1649 028 Lisboa
Portugal
Activity type
Research Organisations
EU contribution
€ 2 113 125

Participants (2)

UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 1 272 840,63
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments
SYNOVO GMBH
Germany
EU contribution
€ 548 000
Address
Paul Ehrlich Str 15
72076 Tuebingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)