CORDIS - EU research results

BRInGing nano-pHoTonics into the brain


Communication material

Communication materials including visual identity and basic project rules for communication

Design of the plasmonic structures

Geometric design of metallic structures realized on the tapered fibers Results of simulations will be reported in terms of electromagnetic field distribution reflectance and transmission spectrum Two different types of plasmonic structures will be designed one that maximizes scattering and one that maximizes absorption for SERS and heat generation respectively

Implementation of the M-2PL System

A M2PL system will be implemented as described in Task 31 able to perform twophoton lithography along the entire taper We will report the design of the system in terms of optical path its spatial resolution and its writing speed

Project website and logo

The project website is online and the project logo is created The project website will be continuously updated during the project


Wavefront engineering for controlled structuring of far-field intensity and phase patterns from multimodal optical fibers

Author(s): Liam Collard, Filippo Pisano, Marco Pisanello, Antonio Balena, Massimo De Vittorio, Ferruccio Pisanello
Published in: APL Photonics, Issue 6/5, 2021, Page(s) 051301, ISSN 2378-0967
Publisher: AIP
DOI: 10.1063/5.0044666

Holographic Manipulation of Nanostructured Fiber Optics Enables Spatially‐Resolved, Reconfigurable Optical Control of Plasmonic Local Field Enhancement and SERS

Author(s): Collard, Liam; Pisano, Filippo; Zheng, Di; Balena, Antonio; Kashif, Muhammad Fayyaz; Pisanello, Marco; D'Orazio, Antonella; De La Prida, Liset M; Ciracì, Cristian; Grande, Marco; De Vittorio, Massimo; Pisanello, Ferruccio
Published in: Small, Issue 14, 2022, ISSN 1613-6829
Publisher: Whiley
DOI: 10.1002/smll.202200975

Comparative study of autofluorescence in flat and tapered optical fibers towards application in depth-resolved fluorescence lifetime photometry in brain tissue

Author(s): Marco Bianco, Antonio Balena, Marco Pisanello, Filippo Pisano, Leonardo Sileo, Barbara Spagnolo, Cinzia Montinaro, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
Published in: Biomedical Optics Express, Issue 12/2, 2021, Page(s) 993, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.410244

Recent Advances on High-Speed and Holographic Two-Photon Direct Laser Writing

Author(s): Antonio Balena, Marco Bianco, Ferruccio Pisanello, Massimo De Vittorio
Published in: Advanced Functional Materials, 2023, ISSN 1616-3028
Publisher: Whiley
DOI: 10.1002/adfm.202211773

Influence of the anatomical features of different brain regions on the spatial localization of fiber photometry signals

Author(s): Cinzia Montinaro, Marco Pisanello, Marco Bianco, Barbara Spagnolo, Filippo Pisano, Antonio Balena, Francesco De Nuccio, Dario Domenico Lofrumento, Tiziano Verri, Massimo De Vittorio, Ferruccio Pisanello
Published in: Biomedical Optics Express, Issue 12/10, 2021, Page(s) 6081, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.439848

Ray tracing models for estimating light collection properties of microstructured tapered optical fibers for optical neural interfaces

Author(s): Emanuela Maglie, Marco Pisanello, Filippo Pisano, Antonio Balena, Marco Bianco, Barbara Spagnolo, Leonardo Sileo, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
Published in: Optics Letters, Issue 45/14, 2020, Page(s) 3856, ISSN 0146-9592
Publisher: Optical Society of America
DOI: 10.1364/ol.397022

Brain Microenvironment Heterogeneity: Potential Value for Brain Tumors

Author(s): Laura Álvaro-Espinosa, Ana de Pablos-Aragoneses, Manuel Valiente, Neibla Priego
Published in: Frontiers in Oncology, Issue 11, 2021, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.714428

Numerical calculation of the light propagation in tapered optical fibers for optical neural interfaces

Author(s): Rosa Mach Batlle, Marco Pisanello, Filippo Pisano, Massimo De Vittorio, Ferruccio Pisanello, Cristian Ciraci
Published in: Journal of Lightwave Technology, 2021, Page(s) 1-1, ISSN 0733-8724
Publisher: Optical Society of America
DOI: 10.1109/jlt.2021.3118898

Roadmap on perovskite nanophotonics

Author(s): Soci C.; Adamo G.; Cortecchia D.; Wang K.; Xiao S.; Song Q.; Schall-Giesecke A.L.; Cegielski P.J.; Lemme M.C.; Gerace D.; Sanvitto D.; Tian J.; Tonkaev P.A.; Makarov S.V.; Kivshar Y.S.; Jimenez Gordillo O.A.; Melloni A.; Pushkarev A.P.; D'Amato M.; Lhuillier E.; Bramati A.
Published in: Optical Materials X, 2022, ISSN 2590-1478
Publisher: Elsevier
DOI: 10.1016/j.omx.2022.100214

A clinically-compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

Author(s): Zhu L, Retana D, García-Gómez P, Alvaro-Espinosa L, Priego N, Masmudi-Martín M, Yebra N, Miarka L, Hernández-Encinas E, Blanco-Aparicio C, Martínez S, Sobrino C, Ajenjo N, Artiga MJ, Ortega-Paino E, Torres-Ruiz R, Rodríguez-Perales S, RENACER, Soffietti R, Bertero L, Cassoni P, Weiss T, Muñoz J, Sepúlveda JM, González-León P, Jiménez-Roldán L, Moreno LM, Esteban O, Pérez-Núñez A, H
Published in: EMBO Molecular Medicine, 2022, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202114552

Two-photon fluorescence-assisted laser ablation of non-planar metal surfaces: fabrication of optical apertures on tapered fibers for optical neural interfaces

Author(s): Antonio Balena, Marco Bianco, Filippo Pisano, Marco Pisanello, Leonardo Sileo, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
Published in: Optics Express, Issue 28/15, 2020, Page(s) 21368, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.395187

Highly Photostable Perovskite Nanocubes: Toward Integrated Single Photon Sources Based on Tapered Nanofibers

Author(s): Stefano Pierini, Marianna D’Amato, Mayank Goyal, Quentin Glorieux, Elisabeth Giacobino, Emmanuel Lhuillier, Christophe Couteau, Alberto Bramati
Published in: ACS Photonics, Issue 7/8, 2020, Page(s) 2265-2272, ISSN 2330-4022
Publisher: American Chemical Society
DOI: 10.1021/acsphotonics.0c00820

The Potential of Astrocytes as Immune Modulators in Brain Tumors

Author(s): Neibla Priego, Manuel Valiente
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers in
DOI: 10.3389/fimmu.2019.01314

Nanofiber based displacement sensor

Author(s): Chengjie Ding, Maxime Joos, Constanze Bach, Tom Bienaimé, Elisabeth Giacobino, E Wu, Alberto Bramati, Quentin Glorieux
Published in: Applied Physics B, Issue 126/6, 2020, ISSN 0946-2171
Publisher: Springer Verlag
DOI: 10.1007/s00340-020-07452-1

Single-cell micro- and nano-photonic technologies

Author(s): Filippo Pisano, Marco Pisanello, Massimo De Vittorio, Ferruccio Pisanello
Published in: Journal of Neuroscience Methods, Issue 325, 2019, Page(s) 108355, ISSN 0165-0270
Publisher: Elsevier BV
DOI: 10.1016/j.jneumeth.2019.108355

Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy

Author(s): Lucía Zhu, Lauritz Miarka, Patricia Baena, María Perea-García, Manuel Valiente
Published in: STAR Protocols, 2023, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2023.102194

Neurophotonic tools for microscopic measurements and manipulation: status report.

Author(s): Ahmed Abdelfattah; Srinivasa Rao Allu; Robert E. Campbell; Xiaojun Cheng; Tomáš Cižmár; Irene Costantini; Valentina Emiliani; Natalie Fomin-Thunemann; Ariel Gilad; Tomás Fernández Alfonso; Christopher G. L. Ferri; Andrew Harris; Elizabeth M. C. Hillman; Matthew G. Holt; Kivilcim Kiliç; Evan W. Miller; Rickson C. Mesquita; K.M. Naga Srinivas Nadella; U. Valentin Nägerl; Citlali Perez Campos
Published in: Neurophotonics, Issue 18, 2022, ISSN 2329-4248
Publisher: SPIE

Label-free biomechanical nanosensor based on LSPR for biological applications

Author(s): M. Salbini, T. Stomeo, C. Ciracì, R. Fiammengo, V. Mangini, A. Toma, F. Pisano, F. Pisanello, T. Verri, D. R. Smith, M. De Vittorio
Published in: Optical Materials Express, Issue 10/5, 2020, Page(s) 1264, ISSN 2159-3930
Publisher: Optical Society of America
DOI: 10.1364/ome.385713

Plasmonics on a Neural Implant: Engineering Light–Matter Interactions on the Nonplanar Surface of Tapered Optical Fibers

Author(s): Pisano, Filippo; Kashif, Muhammad Fayyaz; Balena, Antonio; Pisanello, Marco; De Angelis, Francesco; Prida, Liset M; Valiente, Manuel; D'Orazio, Antonella; De Vittorio, Massimo; Grande, Marco; Pisanello, Ferruccio
Published in: Advanced Optical materials, 2022, ISSN 2195-1071
Publisher: Wiley
DOI: 10.1002/adom.202101649

High transmission from 2D periodic plasmonic finite arrays with sub-20 nm gaps realized with Ga focused ion beam milling

Author(s): Filippo Pisano, Antonio Balena, Muhammad Fayyaz Kashif, Marco Pisanello, Gaia de Marzo, Luciana Algieri, Antonio Qualtieri, Leonardo Sileo, Tiziana Stomeo, Antonella D’Orazio, Massimo De Vittorio, Ferruccio Pisanello, Marco Grande
Published in: Nanotechnology, Issue 31/43, 2020, Page(s) 435301, ISSN 0957-4484
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6528/aba57a

Tapered fibertrodes for optoelectrical neural interfacing in small brain volumes with reduced artefacts

Author(s): Spagnolo, Barbara; Balena, Antonio; Peixoto, Rui T.; Pisanello, Marco; Sileo, Leonardo; Bianco, Marco; Rizzo, Alessandro; Pisano, Filippo; Qualtieri, Antonio; Lofrumento, Dario Domenico; De Nuccio, Francesco; Assad, John A.; Sabatini, Bernardo L.; De Vittorio, Massimo; Pisanello, Ferruccio
Published in: Nature Materials, Issue 16, 2022, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-022-01272-8

Toward Plasmonic Neural Probes: SERS Detection of Neurotransmitters through Gold-Nanoislands-Decorated Tapered Optical Fibers with Sub-10 nm Gaps

Author(s): Di Zheng, Filippo Pisano, Liam Collard, Antonio Balena, Marco Pisanello, Barbara Spagnolo, Rosa Mach-Batlle, Francesco Tantussi, Luigi Carbone, Francesco De Angelis, Manuel Valiente, Liset M. de la Prida, Cristian Ciracì, Massimo De Vittorio, Ferruccio Pisanello
Published in: Advanced Materials, 2023, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/adma.202200902

An open source three-mirror laser scanning holographic two-photon lithography system

Author(s): Pisanello, Marco; Zheng, Di; Balena, Antonio; Pisano, Filippo; De Vittorio, Massimo; Pisanello, Ferruccio
Published in: Plos One, Issue 16, 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0265678

Orthogonalization of far-field detection in tapered optical fibers for depth-selective fiber photometry in brain tissue

Author(s): Marco Bianco, Marco Pisanello, Antonio Balena, Cinzia Montinaro, Filippo Pisano, Barbara Spagnolo, Bernardo L. Sabatini; Massimo De Vittorio; Ferruccio Pisanello
Published in: APL Photonics, 2022, ISSN 2378-0967
Publisher: AIP Publishing
DOI: 10.1063/5.0073594

Color-Tunable Mixed-Cation Perovskite Single Photon Emitters

Author(s): Marianna D’Amato, Qi Ying Tan, Quentin Glorieux, Alberto Bramati, and Cesare Soci
Published in: ACS Photonics, 2023, ISSN 2330-4022
Publisher: American Chemical Society
DOI: 10.1021/acsphotonics.2c01437

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