Descripción del proyecto
Un dispositivo implantable para restablecer la función cardíaca
Los trastornos cardiovasculares a menudo desembocan en una insuficiencia cardíaca (IC), la cual afecta negativamente a la calidad de vida y conlleva un gran coste socioeconómico. Actualmente, no existe medicación capaz de revertir el daño cardíaco; la única opción ante una IC es el trasplante de corazón. En el proyecto LION-HEARTED, financiado con fondos europeos, se ha desarrollado una novedosa tecnología que aúna luz y nanotecnología para restablecer la función cardíaca y la vascularización. En la estrategia participan fototransductores biocompatibles, que activan las rutas biológicas pertinentes para la reparación en progenitores cardíacos. El objetivo de los investigadores es generar un producto sanitario implantable innovador, capaz de restablecer la función cardiovascular y recuperar la perfusión sanguínea sistémica.
Objetivo
Cardiovascular (CV) disease is the leading cause of mortality and morbidity worldwide, with an increasing incidence in the aging population and a huge socio-economical impact. Heart failure (HF), the common end point of virtually all CV disorders, displays the greatest negative impact on quality of life, leading to the disruption of daily management and increasing dependence on care-givers. Unfortunately, an effective pharmacological treatment is currently lacking, as it is not possible to reverse disease progression; as a consequence, the long-term survival remains poor, and heart transplantation is the only possibility for end-stage HF patients. Thus, a breakthrough approach to preserve or, at least, restore cardiovascular function and to rescue systemic blood perfusion is urgently required.
LION-HEARTED will demonstrate a novel optoceutic platform, based on synergistic combination of light and organic nanotechnology, to restore cardiac function and vascularization, by modulating fate and proliferation of main cardiovascular cell types. Optical modulation will provide unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity in respect to traditional electrical and pharmaceutical control methods. Organic semiconductors will act as efficient, highly biocompatible phototransducers, able to trigger biological pathways relevant to cardiac repair, with a minimally invasive and gene-less approach. This strategy will circumvent most of the hurdles currently limiting the efficacy of molecular therapies, by directly stimulating the reparative phenotype of resident cardiac progenitors, cardiomyocytes, and of circulating endothelial cells homing towards the heart after an ischemic insult. The final outcome will be the realization of a proof of concept, implantable device for enhancing cardiac repair in ischemic, aneurysm and stenosis in vivo animal models.
Ámbito científico
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FETOPEN-2018-2019-2020-01
Régimen de financiación
RIA - Research and Innovation actionCoordinador
16163 Genova
Italia