Bridging the gap between Mind, Brain and Body: exosome role and monitoring

Project Information

MindGAP

Grant agreement ID: 829040

DOI

10.3030/829040

Project closed

EC signature date 22 February 2019

Start date 1 April 2019

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 4 435 830,00

EU contribution

€ 4 435 830,00

Coordinated by

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (10)

Outer characterization of EXOs

Outer characterization of EXOs, to find biomarkers to link EXOs to their brain origin.

Website, Logo and Media

Report on the website, logo and eventual media accounts e.g. Facebook, Twitter.

PA assembly on non-conductive substrates

Plastic Antibody assembly on nonconductive substrates

Analytical features with standards

Analytical features with standards.NOTE: analysis should be carried out in the prototype.

PA assembly on conductive substrates

Plastic Antibody assembly on conductive substrates

Specification for sensor and designs planned

Specification for sensor and designs planned.

Computing selected conditions for PA

Computing selected conditions to assembly the plastic antibodies.

Report on Kick-off Meeting

Report on Kick-off meeting

Biomarkers in Brain EXOs (individuals)

Biomarkers in Brain EXOs individuals

Inner characterization of EXOs

Inner characterization of EXOs to examine the cargo of brain-EXOs, as a key element of the transmitted information.

Open Research Data Pilot (1)

Data Management Plan (interim)

Data Management Plan, reporting research data type and size, how it will be stored so that is findable, accessible, interoperable and reusable (FAIR) during and after the project.

Publications

Peer reviewed articles (31)

Evidence of psychological and biological effects of structured Mindfulness‐Based Interventions for cancer patients and survivors: A meta‐review

Author(s): Juliana Pedro, Sara Monteiro‐Reis, Carina Carvalho‐Maia, Rui Henrique, Carmen Jerónimo, Eunice R. Silva
Published in: Psycho-Oncology, Issue 30/11, 2021, Page(s) 1836-1848, ISSN 1057-9249
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pon.5771

Human Adult Astrocyte Extracellular Vesicle Transcriptomics Study Identifies Specific RNAs Which Are Preferentially Secreted as EV Luminal Cargo

Author(s): Shanthi, Keerthanaa Balasubramanian, Daniel Fischer, Abhishek Sharma, Antti Kiviniemi, Mika Kaakinen, Seppo J. Vainio, and Geneviève Bart.
Published in: Genes, Issue 14, 2023, Page(s) 853, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14040853

Trisk 95 as a novel skin mirror for normal and diabetic systemic glucose level

Author(s): Nsrein Ali, Hamid Reza Rezvani, Diana Motei, Sufyan Suleman, Walid Mahfouf, Isabelle Marty, Veli-Pekka Ronkainen, Seppo J. Vainio
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-68972-6

Time-gated Raman spectroscopy and proteomics analyses of hypoxic and normoxic renal carcinoma extracellular vesicles.

Author(s): Anatoliy Samoylenko; Martin Kögler; Artem Zhyvolozhnyi; Olha Makieieva; Genevieve Bart; Sampson Saj Andoh; Matthieu Roussey; Seppo Vainio; Jussi Hiltunen
Published in: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021), Issue 20452322, 2021, Page(s) 1-14, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-99004-6

Identification of extracellular nanoparticle subsets by nuclear magnetic resonance.

Author(s): Sharif Ullah; Vladimir V. Zhivonitko; Anatoliy Samoylenko; Artem Zhyvolozhnyi; Sirja Viitala; Santeri Kankaanpää; Sanna Komulainen; Leif Schröder; Seppo Vainio; Ville-Veikko Telkki
Published in: Chemical Science, Issue 20416539, 2021, Page(s) 8311-8319, ISSN 2041-6539
Publisher: RSC
DOI: 10.1039/d1sc01402a

Smart bio-nano interface derived from zein protein as receptors for biotinyl moiety

Author(s): Subramanian Suriyanarayanan, Sudip Mandal, Kothandaraman Ramanujam, Ian A. Nicholls,
Published in: Talanta, Issue 256, 2023, Page(s) 124298, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2023.124298

An ultrasensitive paper-based SERS sensor for detection of nucleolin using silver-nanostars, plastic antibodies and natural antibodies

Author(s): Akmaral Suleimenova, Manuela F. Frasco, M. Goreti F. Sales
Published in: Talanta, Issue 279, 2024, Page(s) 126543, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2024.126543

Carbon Electrodes with Gold Nanoparticles for the Electrochemical Detection of miRNA 21-5p

Author(s): Verónica Morgado Serrano, Inês Simões Patrício Silva, Ana Rita Cardoso and Maria Goreti Ferreira Sales
Published in: Chemosensors, Issue 22279040, 2022, Page(s) 189, ISSN 2227-9040
Publisher: Chemosensors
DOI: 10.3390/chemosensors10050189

The modulatory role of internet-supported mindfulness-based cognitive therapy on extracellular vesicles and psychological distress in people who have had cancer: a protocol for a two-armed randomized controlled study

Author(s): Diana R. Pereira, Eunice R. Silva, Carina Carvalho-Maia, Sara Monteiro-Reis, Catarina Lourenço, Rita Calisto, Ricardo João Teixeira, Linda E. Carlson, Genevieve Bart, Seppo J. Vainio, M. Goreti F. Sales, Carmen Jerónimo and Rui Henrique 
Published in: Trials, Issue 17456215, 2022, Page(s) 118, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-022-06045-x

Bacterial nanocellulose membrane as novel substrate for biomimetic structural color materials: Application to lysozyme sensing

Author(s): Akmaral Suleimenova, Manuela F. Frasco, Francisco A.G. Soares da Silva, Miguel Gama, Elvira Fortunato, M. Goreti F. Sales
Published in: Biosensors and Bioelectronics: X, Issue 13, 2024, Page(s) 100310, ISSN 2590-1370
Publisher: Elsevier
DOI: 10.1016/j.biosx.2023.100310

Au nanostar nanoparticle as a bio-imaging agent and its detection and visualization in biosystems

Author(s): Perevedentseva, E.; Ali, N.; Lin, Y.-C.; Karmenyan, A.; Chang, C.-C.; Bibikova, O.; Skovorodkin, I.; Prunskaite-Hyyryläinen, R.; Vainio, S. J.; Kinnunen, M.; Cheng, C.-L.
Published in: Biomedical Optics Express, Issue 10, 2020, Page(s) 5872-5885, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.401462

Amplified Sensitivity in SERS Detection of L1CAM With Silver Plasmonic Mesoporous Silica Capsules on an Imprinted Films

Author(s): Yuselis Castaño‐Guerrero, Belén Arjones‐Fernández, Felismina T.C. Moreira, Ramon A. Alvarez‐Puebla, Miguel A. Correa‐Duarte, H. Águas, M. Goreti F. Sales
Published in: Advanced Materials Interfaces, 2024, ISSN 2196-7350
Publisher: Wiley
DOI: 10.1002/admi.202400299

Fabrication and sensing properties of a molecularly imprinted polymer on a photonic PDMS substrate for the optical detection of C-reactive protein

Author(s): Sara Resende, José Fernandes, Patrícia C. Sousa, Carlos Calaza, Manuela F. Frasco, Paulo P. Freitas, M. Goreti F. Sales
Published in: Chemical Engineering Journal, Issue 485, 2024, Page(s) 149924, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/j.cej.2024.149924

Molecular Imprinting on Nanozymes for Sensing Applications

Author(s): Ana R. Cardoso; Manuela F. Frasco; Manuela F. Frasco; Manuela F. Frasco; Verónica M. Serrano; Verónica M. Serrano; Verónica M. Serrano; Elvira Fortunato; Maria Goreti Ferreira Sales; Maria Goreti Ferreira Sales; Maria Goreti Ferreira Sales
Published in: Biosensors, Vol 11, Iss 152, p 152 (2021), Issue 20796374, 2021, Page(s) 152, ISSN 2079-6374
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios11050152

Sustainable synthesis of hierarchically grown chloramphenicol-imprinted poly(caffeic acid) nanostructured films

Author(s): Subramanian Suriyanarayanan, Ganapathi Rao Kandregula, Kothandaraman Ramanujam, Ian A. Nicholls
Published in: Journal of Applied Polymer Synthesis, Issue 140, 2023, Page(s) e53560, ISSN 0021-8995
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/app.53560

Towards Peptide and Protein Recognition by Antibody Mimicking Synthetic Polymers – Background, State of the Art, and Future Outlook

Author(s): Ian A. Nicholls, Jesper G. Wiklander
Published in: Australian Journal of Chemistry, Issue 73/4, 2020, Page(s) 300, ISSN 0004-9425
Publisher: Commonwealth Scientific and Industrial Research Organization Publishing
DOI: 10.1071/ch20020

Recent advances in virus imprinted polymers

Author(s): Mariana S. Amorim, M. Goreti F. Sales and Manuela F. Frasco
Published in: Biosensors and Bioelectronics: X, Issue 25901370, 2022, Page(s) 100131, ISSN 2590-1370
Publisher: Elsevier
DOI: 10.1016/j.biosx.2022.100131

Secreted Extracellular Vesicle Molecular Cargo as a Novel Liquid Biopsy Diagnostics of Central Nervous System Diseases

Author(s): Sara Monteiro-Reis, Carina Carvalho-Maia, Genevieve Bart, Seppo J. Vainio, Juliana Pedro, Eunice R. Silva, Goreti Sales, Rui Henrique, Carmen Jerónimo
Published in: International Journal of Molecular Sciences, Issue 22/6, 2021, Page(s) 3267, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063267

Improved Solvothermal Synthesis of γ-Fe2O3 Magnetic Nanoparticles for SiO2 Coating

Author(s): Rashmi Mahajan, Subramanian Suriyanarayanan, Ian A. Nicholls
Published in: Nanomaterials, Issue 11/8, 2021, Page(s) 1889, ISSN 2079-4991
Publisher: mdpi
DOI: 10.3390/nano11081889

Photonics in nature and bioinspired designs: sustainable approaches for a colourful world

Author(s): Raquel Vaz, Manuela F. Frasco, M. Goreti F. Sales
Published in: Nanoscale Advances, 2020, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0na00445f

Molecular Dynamics in the Study and Development of Molecularly Imprinted Materials – Status Quo, Quo Vadis?

Author(s): Ian A. Nicholls; Kerstin Golker; Jesper G. Wiklander
Published in: Preprints.org, Issue 2022020154, 2022, Page(s) 2022020154, ISSN 2310-287X
Publisher: Preprints
DOI: 10.20944/preprints202202.0154.v1

Portable and Autonomous PEDOT-Modified Flexible Paper-Based Methanol Fuel Cell Sensing Platform Applied to L1CAM Recombinant Protein Detection

Author(s): Liliana P. T. Carneiro, Alexandra M. F. R. Pinto, Dzmitry Ivanou, Adélio M. Mendes, and M. Goreti F. Sales
Published in: ACS applied polymer materials, 2023, Page(s) 3207–3221, ISSN 2637-6105
Publisher: ACS
DOI: 10.1021/acsapm.3c02781

Development of an electrochemical biosensor for galectin-3 detection in point-of-care.

Author(s): Sofia M.V. Cerqueira, Rúben Fernandes, Felismina T.C. Moreira, M. Goreti F. Sales
Published in: Micrhochemical journal, Issue 164, 2021, Page(s) 105992, ISSN 1095-9149
Publisher: Elsevier
DOI: 10.1016/j.microc.2021.105992

Porosity of Molecularly Imprinted Polymers Investigated by ¹²⁹Xe NMR Spectroscopy

Author(s): Matteo Boventi; Michele Mauri; Kerstin Golker; Jesper G. Wiklander; Ian A. Nicholls; Roberto Simonutti
Published in: ACS Applied Polymer Materials, Issue 4, 2022, Page(s) 8740-8749, ISSN 2637-6105
Publisher: ACS
DOI: 10.1021/acsapm.2c01084

Paper-based (bio)sensor for label-free detection of 3-nitrotyrosine in human urine samples using molecular imprinted polymer

Author(s): Gabriela V. Martins, Ana C. Marques, Elvira Fortunato, M. Goreti F. Sales
Published in: Sensing and Bio-Sensing Research, Issue 28, 2020, Page(s) 100333, ISSN 2214-1804
Publisher: Elsevier BV
DOI: 10.1016/j.sbsr.2020.100333

Breaking the classics: Next-generation biosensors for the isolation, profiling and detection of extracellular vesicles

Author(s): Raquel Vaz, Verónica M Serrano, Yuselis Castaño-Guerrero, Ana R. Cardoso, Manuela Frasco, M. Goreti F. Sales
Published in: Biosensors and Bioelectronics: X, Issue 25901370, 2022, Page(s) 100115, ISSN 2590-1370
Publisher: Elsevier
DOI: 10.1016/j.biosx.2022.100115

Urinary volatilomics unveils a candidate biomarker panel for noninvasive detection of clear cell renal cell carcinoma.

Author(s): Joana Pinto, Filipa Amaro, Ana Rita Lima, Carina Carvalho-Maia, Carmen Jerónimo, Rui Henrique, Maria de Lourdes Bastos, Márcia Carvalho, and Paula Guedes de Pinho
Published in: Journal of Proteome research, Issue 20, 2021, Page(s) 3068–3077, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00936

MicroRNAs in Extracellular Vesicles in Sweat Change in Response to Endurance Exercise

Author(s): Sira Karvinen, Tero Sievänen, Jari E. Karppinen, Pekka Hautasaari, Geneviève Bart, Anatoliy Samoylenko, Seppo J. Vainio, Juha P. Ahtiainen, Eija K. Laakkonen, Urho M. Kujala
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00676

Oxytocin-Selective Nanogel Antibody Mimics

Author(s): Rashmi Mahajan, Subramanian Suriyanarayanan, Gustaf D. Olsson, Jesper G. Wiklander, Teodor Aastrup, Börje Sellergren and Ian A. Nicholls
Published in: International Journal of Molecular Sciences, Issue 14220067, 2022, Page(s) 2534, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23052534

Green photonic biosensing: Approaching sustainability in point-of-care diagnostics

Author(s): Raquel Vaz, M. Goreti F. Sales, Manuela F. Frasco
Published in: TrAC, Trends in Analytical Chemistry, Issue 177, 2024, Page(s) 117771, ISSN 0165-9936
Publisher: Elsevier BV
DOI: 10.1016/j.trac.2024.117771

Detection of serum calprotectin based on molecularly imprinted photonic hydrogels: A novel approach for IBD diagnosis

Author(s): Sara Resende, Manuela F. Frasco, Paulo P. Freitas, M. Goreti F. Sales
Published in: Biosensors and Bioelectronics: X, Issue 13, 2023, Page(s) 100313, ISSN 2590-1370
Publisher: Elsevier
DOI: 10.1016/j.biosx.2023.100313

Conference proceedings (2)

Bioinspired photonic polymeric sensors for analysing exosomes

Author(s): Vaz, Raquel; Frasco, Manuela; Sales, M. G. F.
Published in: Encontro Ciência'21. Lisboa, Jun 28-30, 2021., 2020
Publisher: FCT

Bioinspired photonic polymeric sensors for analysing exosomes

Author(s): Vaz, Raquel; Frasco, Manuela; Sales, M. G. F.
Published in: Encontro Ciência'21. Lisboa, Jun 28-30, 2021., Issue 7, 2021
Publisher: FCT

Book chapters (3)

Using Molecular in the Study of Molecularly Imprinted

Author(s): Gustaf D. Olsson, Jesper G. Wiklander, Ian A. Nicholls
Published in: Molecularly Imprinted Polymers - Methods and Protocols, Issue 2359, 2021, Page(s) 241-268, ISBN 978-1-0716-1628-4
Publisher: Springer US
DOI: 10.1007/978-1-0716-1629-1_21

Biomimetic strategies for biosensing

Author(s): Ana R. Cardoso, Liliana P.T. Carneiro, Akmaral Suleimenova, Manuela F. Frasco, M. Goreti F. Sales
Published in: Nature-Derived Sensors, 2025, Page(s) 223-265
Publisher: Elsevier
DOI: 10.1016/b978-0-443-22002-9.00003-8

Biosensors: concept and importance in point-of-care disease diagnosis

Author(s): Raquel Vaz, Manuela F. Frasco and M. Goreti F. Sales
Published in: Biosensor Based Advanced Cancer Diagnostics, From Lab to Clinics, 2021, Page(s) 59-84, ISBN 978-0-12-823424-2
Publisher: Academic Press
DOI: 10.1016/b978-0-12-823424-2.00001-6

Non-peer reviewed articles (1)

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

Author(s): Ian A. Nicholls, Kerstin Golker, Gustaf D. Olsson, Subramanian Suriyanarayanan, Jesper G. Wiklander
Published in: Polymers, Issue 13/17, 2021, Page(s) 2841, ISSN 2073-4360
Publisher: mdpi
DOI: 10.3390/polym13172841