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A STEP FORWARD TO SPINAL CORD INJURY REPAIR USING INNOVATIVE STIMULATED NANOENGINEERED SCAFFOLDS

Objective

Spinal cord injury (SCI) is a devastating pathology with dramatic lifetime consequences affecting thousands of people worldwide. Therefore, and considering the very limited regeneration ability of the central nervous system, in this project we propose to develop a neural tissue engineered scaffold capable of not only combining fibrous and porous topographic cues in order to mimic the morphology of the native spinal cord, but also potentiating the properties of graphene related materials (GRM) supported in a protein-rich decellularized matrix (adECM). In fact, the suggested 3D microenvironment should present electrical, chemical, mechanical and topographic features able to preserve neural cell survival and enhance neural progenitor cell differentiation towards neuronal and glial cells. Progress in this sense will contribute to a better understanding of the key factors controlling repair in damaged neural tissues and, consequently, bring insights into new therapeutic approaches for spinal cord recovery.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /engineering and technology/nanotechnology/nano-materials/two-dimensional nanostructures/graphene

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSIDADE DE AVEIRO
Address
Campus Universitário De Santiago
3810-193 Aveiro
Portugal
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 075 260

Participants (6)

FUNDACION TECNALIA RESEARCH & INNOVATION
Spain
EU contribution
€ 727 162,50
Address
Parque Cientifico Y Tecnologico De Gipuzkoa Paseo Mikeletegi 2
20009 Donostia/san Sebastian (Gipuzkoa)
Activity type
Research Organisations
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 251 250
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 500 000
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 338 375
Address
N Plastira Str 100
70013 Irakleio
Activity type
Research Organisations
GRAPHENEST SA
Portugal
EU contribution
€ 208 750
Address
Lugar De Estacao Edificio Vougapark Piso 2 Sala 107 2
3740 070 Paradela Svv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STEMMATTERS, BIOTECNOLOGIA E MEDICIINA REGENERATIVA SA
Portugal
EU contribution
€ 403 125
Address
Parque De Ciencia E Tecnologia Avepark Zona Industrial Da Gandra
4805-017 Barco Gmr
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)