Project description DEENESFRITPL A stimulus responsive 3D neural scaffold for spinal cord injury Inherently, the central nervous system exhibits limited regenerative capacity. As a result, spinal cord injuries cause partial or total loss of motor and sensory function. To improve our understanding of the key factors controlling repair in damaged neural tissues, the EU-funded NeuroStimSpinal project is working on an engineered neural scaffold that mimics the morphology of the native spinal cord. The scaffold combines graphene materials and a decellularised extracellular matrix to provide electrical, chemical, mechanical and topographic cues to neural progenitor cells. The scaffold will facilitate the progenitor cell differentiation towards neuronal and glial cells, offering an invaluable tool for neuroscience research. Show the project objective Hide the project objective Objective Spinal cord injury (SCI) is a devastating pathology with dramatic lifetime consequences affecting thousands of people worldwide. Therefore, and considering the very limited regeneration ability of the central nervous system, in this project we propose to develop a neural tissue engineered scaffold capable of not only combining fibrous and porous topographic cues in order to mimic the morphology of the native spinal cord, but also potentiating the properties of graphene related materials (GRM) supported in a protein-rich decellularized matrix (adECM). In fact, the suggested 3D microenvironment should present electrical, chemical, mechanical and topographic features able to preserve neural cell survival and enhance neural progenitor cell differentiation towards neuronal and glial cells. Progress in this sense will contribute to a better understanding of the key factors controlling repair in damaged neural tissues and, consequently, bring insights into new therapeutic approaches for spinal cord recovery. Fields of science natural sciencesbiological sciencesneurobiologyengineering and technologynanotechnologynano-materialstwo-dimensional nanostructuresgraphenemedical and health sciencesbasic medicinepathology Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking Call for proposal H2020-FETOPEN-2018-2020 See other projects for this call Sub call H2020-FETOPEN-2018-2019-2020-01 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSIDADE DE AVEIRO Net EU contribution € 1 075 260,00 Address Campus universitário de santiago 3810-193 Aveiro Portugal See on map Region Continente Centro (PT) Região de Aveiro Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all FUNDACION TECNALIA RESEARCH & INNOVATION Spain Net EU contribution € 727 162,50 Address Parque cientifico y tecnologico de gipuzkoa, paseo mikeletegi 2 20009 Donostia-san sebastian (gipuzkoa) See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDAD COMPLUTENSE DE MADRID Spain Net EU contribution € 251 250,00 Address Avenida de seneca 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STICHTING RADBOUD UNIVERSITEIT Participation ended Netherlands Net EU contribution € 99 232,51 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IDRYMA TECHNOLOGIAS KAI EREVNAS Greece Net EU contribution € 338 375,00 Address N plastira str 100 70013 Irakleio See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 GRAPHENEST SA Portugal Net EU contribution € 208 750,00 Address Lugar de estacao edificio vougapark piso 2 sala 107 2 3740 070 Paradela svv See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Norte Área Metropolitana do Porto Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STEMMATTERS, BIOTECNOLOGIA E MEDICIINA REGENERATIVA SA Portugal Net EU contribution € 403 125,00 Address Parque de ciencia e tecnologia avepark zona industrial da gandra 4805-017 Barco gmr See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Norte Ave Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM Netherlands Net EU contribution € 400 767,49 Address Geert grooteplein 10 zuid 6525 GA Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 15 040,00
