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Super-sensitive detection of Alzheimer’s disease biomarkers in plasma by an innovative droplet split-and-stack approach

Deliverables

First prototypes of climate chamber module and liquid handling module and specification for the automated system

Realization of the first prototypes of climate chamber module and liquid handling module and specification for the automated system

First prototype of the three individual layers for successive full integration

Realization of the first prototype of the three individual layers for successive full integration of the super-sensor.

Logo and webpage

Realization of the logo of the Project and of a dedicated website with domain .eu in the address.

Flyers with project targets and first results and promotional movie

Flyers which describe the project targets and the first results achieved. Movie which explains the aims of the Project and its impact in order to disseminate as best as possible the research activities.

International Symposium

Organization of an International Symposium involving the main Universities and Research Centers and Companies working in the field of early diagnosis in neurodegenerative diseases but also on fields regarding microscale fluid handling and immunoreactions at sub-microliter levels.

Final plan for dissemination and exploitation

Report on the final plan for dissemination and exploitation of the results

Technical/scientific review meeting 1 documents

Document delivered as first report with a summary on the work in progress and on the use of resources including those regarding the dissemination activities

Report on sensitivity and specificity for tau

Report containing the data obtained for the sensitivity and the specificity of the supersensor for the biomarker tau

Report on sensitivity and specificity for Abeta1-42

Report containing the data concerning the results on the sensitivity and specificity of the supersensor for the biomarker Abeta142

Report on sensitivity and specificity for P-tau

Report document containing the data obtained for the sensitivity and the specificity of the supersensor for the biomarker Ptau

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Publications

High‐Rate Accumulation of Tiny Aqueous Droplets Using a Pyroelectrohydrodynamic Jet System

Author(s): Volodymyr Tkachenko, Reinhard Schwödiauer, Romina Rega, Simona Itri, Martina Mugnano, Danila del Giudice, Heidi Ottevaere, Yunfeng Nie, Pietro Ferraro, Simonetta Grilli
Published in: Advanced Engineering Materials, 2021, Page(s) 2100756, ISSN 1438-1656
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adem.202100756

Direct printing of gold nanospheres from colloidal solutions by pyro-electrohydrodynamic jet allows hypersensitive SERS sensing

Author(s): Marianna Pannico, Pellegrino Musto, Romina Rega, Veronica Vespini, Simonetta Grilli, Pietro Ferraro
Published in: Applied Surface Science, 531, 2020, Page(s) 147393, ISSN 0169-4332
Publisher: Elsevier BV
DOI: 10.1016/j.apsusc.2020.147393

Rapid Formation of Self‐Supporting Polydimethylsiloxane Sheets with Periodic Clusters of Embedded Nickel Nanoparticles

Author(s): Romina Rega, Juan Francisco Muñoz Martinez, Vito Pagliarulo, Angela Longo, Mariano Palomba, Gianfranco Carotenuto, Pietro Ferraro, Simonetta Grilli
Published in: Advanced Materials Interfaces, 2021, Page(s) 2002216, ISSN 2196-7350
Publisher: Wiley-VCH GmbH
DOI: 10.1002/admi.202002216

Cellular Uptake of Mildly Oxidized Nanographene for Drug-Delivery Applications

Author(s): M. Mugnano, G. C. Lama, R. Castaldo, V. Marchesano, F. Merola, D. del Giudice, A. Calabuig, G. Gentile, V. Ambrogi, P. Cerruti, P. Memmolo, V. Pagliarulo, P. Ferraro, S. Grilli
Published in: ACS Applied Nano Materials, 3/1, 2019, Page(s) 428-439, ISSN 2574-0970
Publisher: ACS Publications
DOI: 10.1021/acsanm.9b02035

Detecting Collagen Molecules at Picogram Level through Electric Field-Induced Accumulation

Author(s): Romina Rega, Martina Mugnano, Emilia Oleandro, Volodymyr Tkachenko, Danila del Giudice, Gianluca Bagnato, Pietro Ferraro, Simonetta Grilli, Sebastiano Gangemi
Published in: Sensors, 20/12, 2020, Page(s) 3567, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20123567

Quantitative determination of rapid biomass formation on pyro-electrifiedpolymer sheets

Author(s): Emilia Oleandro, Romina Rega, Martina Mugnano, Filomena Nazzaro, Pietro Ferraro, Simonetta Grilli
Published in: Biofilm, 3, 2021, Page(s) 100040, ISSN 2590-2075
Publisher: Elsevier
DOI: 10.1016/j.bioflm.2020.100040

Pyro-Electrification of Freestanding Polymer Sheets: A New Tool for Cation-Free Manipulation of Cell Adhesion in vitro

Author(s): Romina Rega, Oriella Gennari, Laura Mecozzi, Vito Pagliarulo, Martina Mugnano, Emilia Oleandro, Filomena Nazzaro, Pietro Ferraro, Simonetta Grilli
Published in: Frontiers in Chemistry, 7, 2019, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2019.00429

A pin-based pyro-electrohydrodynamic jet sensor for tuning theaccumulation of biomolecules down to sub-picogram level detection

Author(s): The detection of low abundant biomarkers is of great interest in different clinical cases, such as the early diagnosis of Alzheimer's disease. Here we present what we call pin-based pyro-electrohydrodynamic jet (p-jet) sensor that can linearly tune the accumulation rate of biomolecules in tiny droplets. In this newly revealed pinbased configuration we demonstrate the ability to detect biomolecules
Published in: Sensing and Bio-Sensing Research, 22141804, 2022, ISSN 2214-1804
Publisher: Elsevier BV
DOI: 10.1016/j.sbsr.2022.100536

Dispensing pico droplets by pyroelectrohydrodynamic jetting: simulations and experimental results

Author(s): Anna Faraone
Published in: 2019
Publisher: Zendo
DOI: 10.5281/zenodo.3530462

Numerical simulations of droplet dynamics through an orifice – pin system for pyroelectrodynamic shooting

Author(s): Pentella Domenico
Published in: 2020
Publisher: Zenodo
DOI: 10.5281/zenodo.4767244

SensApp: a FET-open project for developing a supersensor able to detect Alzheimer's disease biomarkers in blood

Author(s): Romina Rega, Martina Mugnano, Danila del Giudice, Simona Itri, Volodymyr Tkachenko, Veronica Vespini, Sara Coppola, Pietro Ferraro, Heidi Ottevaere, Yunfeng Nie, Sanna Uusitalo, Reinhard Schwoediauer, Martin Kaltenbrunner, Markku Känsäkoski, Emanuela Mazzon, Pier Luca Maffettone, Gaetano D'Avino, Simonetta Grilli
Published in: Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, 2021, Page(s) 58, ISBN 9781510644076
Publisher: SPIE
DOI: 10.1117/12.2596966

Highly sensitive detection of low abundant molecules by pyro-electrohydro-dynamic jetting

Author(s): ROMINA REGA, Martina Mugnano, Danila Del Giudice, Simona Itri, Volodymyr Tkachenko, veronica Vespini, Sara Coppola, Emanuela Mazzon, Emilia Oleandro, Pietro Ferraro, Simonetta Grilli
Published in: Biophotonics in Point-of-Care, 2020, Page(s) 38, ISBN 9781510634954
Publisher: SPIE
DOI: 10.1117/12.2564859