Super-sensitive detection of Alzheimer’s disease biomarkers in plasma by an innovative droplet split-and-stack approach

Rezultaty

Integrated system for calibration and testing
First prototypes of climate chamber module and liquid handling module and specification for the automated system

Realization of the first prototypes of climate chamber module and liquid handling module and specification for the automated system

First prototype of the three individual layers for successive full integration

Realization of the first prototype of the three individual layers for successive full integration of the super-sensor.

Logo and webpage

Realization of the logo of the Project and of a dedicated website with domain .eu in the address.

Flyers with project targets and first results and promotional movie

Flyers which describe the project targets and the first results achieved. Movie which explains the aims of the Project and its impact in order to disseminate as best as possible the research activities.

International Symposium

Organization of an International Symposium involving the main Universities and Research Centers and Companies working in the field of early diagnosis in neurodegenerative diseases but also on fields regarding microscale fluid handling and immunoreactions at sub-microliter levels.

Final plan for dissemination and exploitation

Report on the final plan for dissemination and exploitation of the results

Technical/scientific review meeting 1 documents

Document delivered as first report with a summary on the work in progress and on the use of resources including those regarding the dissemination activities

Report on sensitivity and specificity for tau

Report containing the data obtained for the sensitivity and the specificity of the supersensor for the biomarker tau

Report on sensitivity and specificity for Abeta1-42

Report containing the data concerning the results on the sensitivity and specificity of the supersensor for the biomarker Abeta142

Report on sensitivity and specificity for P-tau

Report document containing the data obtained for the sensitivity and the specificity of the supersensor for the biomarker Ptau

Publikacje

High‐Rate Accumulation of Tiny Aqueous Droplets Using a Pyroelectrohydrodynamic Jet System

Autorzy: Volodymyr Tkachenko, Reinhard Schwödiauer, Romina Rega, Simona Itri, Martina Mugnano, Danila del Giudice, Heidi Ottevaere, Yunfeng Nie, Pietro Ferraro, Simonetta Grilli
Opublikowane w: Advanced Engineering Materials, 2021, Strona(/y) 2100756, ISSN 1438-1656
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adem.202100756

Direct printing of gold nanospheres from colloidal solutions by pyro-electrohydrodynamic jet allows hypersensitive SERS sensing

Autorzy: Marianna Pannico, Pellegrino Musto, Romina Rega, Veronica Vespini, Simonetta Grilli, Pietro Ferraro
Opublikowane w: Applied Surface Science, Numer 531, 2020, Strona(/y) 147393, ISSN 0169-4332
Wydawca: Elsevier BV
DOI: 10.1016/j.apsusc.2020.147393

Miniaturized, high numerical aperture confocal fluorescence detection enhanced with pyroelectric droplet accumulation for sub-attomole analyte diagnosis

Autorzy: YUNFENG NIE, UUSITALO SANNA, TEEMU SIPOLA, ANNUKKA KOKKONEN, INKA PÄKKILÄ, JUHA SUMEN, KATARIINA RAHKAMAA-TOLONEN, VOLODYMYR TKACHENKO, VERONICA VESPINI, SARA COPPOLA, PIETRO FERRARO, SIMONETTA GRILLI, HEIDI OTTEVAERE
Opublikowane w: Biomedical Optics Express, 2023, ISSN 2156-7085
Wydawca: The Optical Society
DOI: 10.1364/boe.504757

High-accuracy characterization of pyroelectric materials: A noncontact method based on surface potential measurements

Autorzy: Reinhard Schwödiauer, Simona Bauer-Gogonea, Martin Kaltenbrunner, Volodymyr Tkachenko, Simonetta Grilli
Opublikowane w: JOURNAL OF ADVANCED DIELECTRICS, 2023, ISSN 2010-1368
Wydawca: World Scientific
DOI: 10.1142/s2010135x23410023

Rapid Formation of Self‐Supporting Polydimethylsiloxane Sheets with Periodic Clusters of Embedded Nickel Nanoparticles

Autorzy: Romina Rega, Juan Francisco Muñoz Martinez, Vito Pagliarulo, Angela Longo, Mariano Palomba, Gianfranco Carotenuto, Pietro Ferraro, Simonetta Grilli
Opublikowane w: Advanced Materials Interfaces, 2021, Strona(/y) 2002216, ISSN 2196-7350
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/admi.202002216

Cellular Uptake of Mildly Oxidized Nanographene for Drug-Delivery Applications

Autorzy: M. Mugnano, G. C. Lama, R. Castaldo, V. Marchesano, F. Merola, D. del Giudice, A. Calabuig, G. Gentile, V. Ambrogi, P. Cerruti, P. Memmolo, V. Pagliarulo, P. Ferraro, S. Grilli
Opublikowane w: ACS Applied Nano Materials, Numer 3/1, 2019, Strona(/y) 428-439, ISSN 2574-0970
Wydawca: ACS Publications
DOI: 10.1021/acsanm.9b02035

Detecting Collagen Molecules at Picogram Level through Electric Field-Induced Accumulation

Autorzy: Romina Rega, Martina Mugnano, Emilia Oleandro, Volodymyr Tkachenko, Danila del Giudice, Gianluca Bagnato, Pietro Ferraro, Simonetta Grilli, Sebastiano Gangemi
Opublikowane w: Sensors, Numer 20/12, 2020, Strona(/y) 3567, ISSN 1424-8220
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20123567

Quantitative determination of rapid biomass formation on pyro-electrifiedpolymer sheets

Autorzy: Emilia Oleandro, Romina Rega, Martina Mugnano, Filomena Nazzaro, Pietro Ferraro, Simonetta Grilli
Opublikowane w: Biofilm, Numer 3, 2021, Strona(/y) 100040, ISSN 2590-2075
Wydawca: Elsevier
DOI: 10.1016/j.bioflm.2020.100040

Pyro-Electrification of Freestanding Polymer Sheets: A New Tool for Cation-Free Manipulation of Cell Adhesion in vitro

Autorzy: Romina Rega, Oriella Gennari, Laura Mecozzi, Vito Pagliarulo, Martina Mugnano, Emilia Oleandro, Filomena Nazzaro, Pietro Ferraro, Simonetta Grilli
Opublikowane w: Frontiers in Chemistry, Numer 7, 2019, ISSN 2296-2646
Wydawca: Frontiers
DOI: 10.3389/fchem.2019.00429

A pin-based pyro-electrohydrodynamic jet sensor for tuning theaccumulation of biomolecules down to sub-picogram level detection

Autorzy: The detection of low abundant biomarkers is of great interest in different clinical cases, such as the early diagnosis of Alzheimer's disease. Here we present what we call pin-based pyro-electrohydrodynamic jet (p-jet) sensor that can linearly tune the accumulation rate of biomolecules in tiny droplets. In this newly revealed pinbased configuration we demonstrate the ability to detect biomolecules
Opublikowane w: Sensing and Bio-Sensing Research, Numer 22141804, 2022, ISSN 2214-1804
Wydawca: Elsevier BV
DOI: 10.1016/j.sbsr.2022.100536

Dispensing pico droplets by pyroelectrohydrodynamic jetting: simulations and experimental results

Autorzy: Anna Faraone
Opublikowane w: 2019
Wydawca: Zendo
DOI: 10.5281/zenodo.3530462

Numerical simulations of droplet dynamics through an orifice – pin system for pyroelectrodynamic shooting

Autorzy: Pentella Domenico
Opublikowane w: 2020
Wydawca: Zenodo
DOI: 10.5281/zenodo.4767244

SensApp: a FET-open project for developing a supersensor able to detect Alzheimer's disease biomarkers in blood

Autorzy: Romina Rega, Martina Mugnano, Danila del Giudice, Simona Itri, Volodymyr Tkachenko, Veronica Vespini, Sara Coppola, Pietro Ferraro, Heidi Ottevaere, Yunfeng Nie, Sanna Uusitalo, Reinhard Schwoediauer, Martin Kaltenbrunner, Markku Känsäkoski, Emanuela Mazzon, Pier Luca Maffettone, Gaetano D'Avino, Simonetta Grilli
Opublikowane w: Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, 2021, Strona(/y) 58, ISBN 9781510644076
Wydawca: SPIE
DOI: 10.1117/12.2596966

Highly sensitive detection of low abundant molecules by pyro-electrohydro-dynamic jetting

Autorzy: ROMINA REGA, Martina Mugnano, Danila Del Giudice, Simona Itri, Volodymyr Tkachenko, veronica Vespini, Sara Coppola, Emanuela Mazzon, Emilia Oleandro, Pietro Ferraro, Simonetta Grilli
Opublikowane w: Biophotonics in Point-of-Care, 2020, Strona(/y) 38, ISBN 9781510634954
Wydawca: SPIE
DOI: 10.1117/12.2564859

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