Mechanistic basis of nucleation and spreading underlying a Polycomb-mediated epigenetic switch

Project Information

EPISWITCH

Grant agreement ID: 833254

DOI 10.3030/833254

EC signature date 17 April 2019

Start date 1 September 2019

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 101 325,00

EU contribution € 2 101 325,00

Coordinated by

JOHN INNES CENTRE
United Kingdom

Deliverables

Open Research Data Pilot (1)

Data Managaement Plan

Data Management Plan

Publications

Peer reviewed articles (9)

In vivo single-molecule analysis reveals COOLAIR RNA structural diversity

Author(s): Yang M, Zhu P, Cheema J, Bloomer R, Mikulski P, Liu Q, Zhang Y, Dean C, Ding Y
Published in: Nature, Issue 00280836, 2022, Page(s) 394-399, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05135-9

The 3′ processing of antisense RNAs physically links to chromatin-based transcriptional control

Author(s): Xiaofeng Fang, Zhe Wu, Oleg Raitskin, Kimberly Webb, Philipp Voigt, Tiancong Lu, Martin Howard, Caroline Dean
Published in: Proceedings of the National Academy of Sciences, Issue 117/26, 2020, Page(s) 15316-15321, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2007268117

VAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin regulation at Arabidopsis FLC.

Author(s): Mikulski P, Wolff P, Lu T, Nielsen M, Zhu D, Franco-Echevarria E, Questa J, Dean C
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32897-7

Plant vernalization proteins contain unusual PHD superdomains without histone H3 binding activity

Author(s): Franco-Echevarría E, Rutherford TJ, Fiedler M, Dean C, Bienz M
Published in: Journal of Biological Chemistry, Issue 00219258, 2022, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.102540

The intersection of DNA replication with antisense 3' RNA processing in Arabidopsis FLC chromatin silencing

Author(s): Baxter CL, Šviković S, Sale JE, Dean C, Costa S
Published in: Proceedings of the National Academy of Sciences, Issue Vol. 118 No. 28, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2107483118

R-loop resolution promotes co-transcriptional chromatin silencing

Author(s): Congyao Xu, Zhe Wu, Hong-Chao Duan, Xiaofeng Fang, Guifang Jia, Caroline Dean
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22083-6

Digital paradigm for Polycomb epigenetic switching and memory

Author(s): Menon G, Schulten A., Dean C., Howard M.
Published in: Current Opinion in Plant Biology, Issue Volume 61, 2021, Page(s) 102012, ISSN 1369-5266
Publisher: Elsevier BV
DOI: 10.1016/j.pbi.2021.102012

Cold-induced Arabidopsis FRIGIDA nuclear condensates for FLC repression

Author(s): Zhu P, Lister, C, Dean C
Published in: Nature, Issue 599, 2021, Page(s) 657-661, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04062-5

Antagonistic cotranscriptional regulation through ARGONAUTE1 and the THO/TREX complex orchestrates FLC transcriptional output

Author(s): Xu C, Fang X, Lu T, Dean C
Published in: Proceedings of the National Academy of Sciences, Issue Vol. 118 No. 47, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2113757118