Mechanistic basis of nucleation and spreading underlying a Polycomb-mediated epigenetic switch

Project Information

EPISWITCH

Grant agreement ID: 833254

DOI

10.3030/833254

Project closed

EC signature date 17 April 2019

Start date 1 September 2019

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 101 325,00

EU contribution

€ 2 101 325,00

Coordinated by

JOHN INNES CENTRE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Managaement Plan

Data Management Plan

Publications

Peer reviewed articles (14)

Distinct accessory roles of<i>Arabidopsis</i>VEL proteins in Polycomb silencing

Author(s): Elsa Franco-Echevarría, Mathias Nielsen, Anna Schulten, Jitender Cheema, Tomos E. Morgan, Mariann Bienz, Caroline Dean
Published in: Genes &amp; Development, Issue 37, 2023, Page(s) 801-817, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.350814.123

In vivo single-molecule analysis reveals COOLAIR RNA structural diversity

Author(s): Yang M, Zhu P, Cheema J, Bloomer R, Mikulski P, Liu Q, Zhang Y, Dean C, Ding Y
Published in: Nature, Issue 00280836, 2022, Page(s) 394-399, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05135-9

The 3′ processing of antisense RNAs physically links to chromatin-based transcriptional control

Author(s): Xiaofeng Fang, Zhe Wu, Oleg Raitskin, Kimberly Webb, Philipp Voigt, Tiancong Lu, Martin Howard, Caroline Dean
Published in: Proceedings of the National Academy of Sciences, Issue 117/26, 2020, Page(s) 15316-15321, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2007268117

Causal role of a promoter polymorphism in natural variation of the Arabidopsis floral repressor gene FLC

Author(s): Pan Zhu, Michael Schon, Julia Questa, Michael Nodine, Caroline Dean
Published in: Current Biology, Issue 33, 2025, Page(s) 4381-4391.e3, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2023.08.079

Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC

Author(s): Miguel Montez, Danling Zhu, Jan Huertas, M. Julia Maristany, Bas Rutjens, Mathias Nielsen, Rosana Collepardo-Guevara, Caroline Dean
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-60735-z

<i>COOLAIR</i> and PRC2 function in parallel to silence <i>FLC</i> during vernalization

Author(s): Mathias Nielsen, Govind Menon, Yusheng Zhao, Eduardo Mateo-Bonmati, Philip Wolff, Shaoli Zhou, Martin Howard, Caroline Dean
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2311474121

VAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin regulation at Arabidopsis FLC.

Author(s): Mikulski P, Wolff P, Lu T, Nielsen M, Zhu D, Franco-Echevarria E, Questa J, Dean C
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32897-7

Plant vernalization proteins contain unusual PHD superdomains without histone H3 binding activity

Author(s): Franco-Echevarría E, Rutherford TJ, Fiedler M, Dean C, Bienz M
Published in: Journal of Biological Chemistry, Issue 102540, 2022, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.102540

VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing

Author(s): Anna Schulten, Geng-Jen Jang, Alex Payne-Dwyer, Marc Fiedler, Mathias L. Nielsen, Eduardo Mateo-Bonmatí, Mariann Bienz, Mark C. Leake, Caroline Dean
Published in: Molecular Cell, Issue 85, 2026, Page(s) 3321-3332.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2025.08.002

The intersection of DNA replication with antisense 3' RNA processing in Arabidopsis FLC chromatin silencing

Author(s): Baxter CL, Šviković S, Sale JE, Dean C, Costa S
Published in: Proceedings of the National Academy of Sciences, Issue Vol. 118 No. 28, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2107483118

R-loop resolution promotes co-transcriptional chromatin silencing

Author(s): Congyao Xu, Zhe Wu, Hong-Chao Duan, Xiaofeng Fang, Guifang Jia, Caroline Dean
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22083-6

Digital paradigm for Polycomb epigenetic switching and memory

Author(s): Menon G, Schulten A., Dean C., Howard M.
Published in: Current Opinion in Plant Biology, Issue Volume 61, 2021, Page(s) 102012, ISSN 1369-5266
Publisher: Elsevier BV
DOI: 10.1016/j.pbi.2021.102012

Cold-induced Arabidopsis FRIGIDA nuclear condensates for FLC repression

Author(s): Zhu P, Lister, C, Dean C
Published in: Nature, Issue 599, 2021, Page(s) 657-661, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04062-5

Antagonistic cotranscriptional regulation through ARGONAUTE1 and the THO/TREX complex orchestrates FLC transcriptional output

Author(s): Xu C, Fang X, Lu T, Dean C
Published in: Proceedings of the National Academy of Sciences, Issue Vol. 118 No. 47, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2113757118