New Horizons in C–H Activation: the ‘Real-World Molecules’ Challenge

Project Information

RuCat

Grant agreement ID: 833337

DOI

10.3030/833337

Project closed

EC signature date 4 April 2019

Start date 1 September 2019

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 498 960,00

EU contribution

€ 2 498 959,00

Coordinated by

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

An air- and moisture-stable ruthenium precatalyst for diverse reactivity

Author(s): Gillian McArthur, Jamie H. Docherty, Mishra Deepak Hareram, Marco Simonetti, Iñigo J. Vitorica-Yrezabal, James J. Douglas, Igor Larrosa
Published in: Nature Chemistry, Issue 16, 2024, Page(s) 1141-1150, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-024-01481-5

Improving the sustainability of the ruthenium-catalysed <i>N</i>-directed C–H arylation of arenes with aryl halides

Author(s): Michael T. Findlay; Ashley S. Hogg; James J. Douglas; Igor Larrosa
Published in: Green Chemistry, Issue 1, 2023, ISSN 1463-9270
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2gc03860a

Ruthenium-Catalyzed Monoselective C–H Methylation and d3-Methylation of Arenes

Author(s): Ashley Hogg, Matthew Wheatley, Pablo Domingo-Legarda, Asier Carral-Menoyo, Naomi Cottam, and Igor Larrosa
Published in: JACS Au, 2022, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.2c00399

The Mechanism of Ruthenium‐Catalyzed Directed C─H Arylation of Arenes: The Key Role of Bis‐Cyclometalated Intermediates

Author(s): Pablo Domingo‐Legarda, Samuel E. Neale, Ambre Carpentier, Claire L. McMullin, Michael Findlay, Igor Larrosa, Stuart A. Macgregor
Published in: Angewandte Chemie International Edition, Issue 64, 2026, Page(s) e202506707, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202506707

Transition-Metal-Catalyzed C–H Bond Activation for the Formation of C–C Bonds in Complex Molecules

Author(s): Jamie H. Docherty; Thomas M. Lister; Gillian Mcarthur; Michael T. Findlay; Pablo Domingo-Legarda; Jacob Kenyon; Shweta Choudhary; Igor Larrosa
Published in: Chemical Reviews, Issue 2, 2023, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.2c00888

Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(sp2)–H functionalization

Author(s): Jamie H. Docherty, Mishra Deepak Hareram, Luke M. Nichols, Ignacio Pérez-Ortega, Iñigo J. Vitorica-Yrezabal, Igor Larrosa
Published in: Nature Catalysis, Issue 8, 2025, Page(s) 301-314, ISSN 2520-1158
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41929-025-01309-6

Unlocking regioselective meta-alkylation with epoxides and oxetanes via dynamic kinetic catalyst control

Author(s): Peng-Bo Bai, Alastair Durie, Gang-Wei Wang, Igor Larrosa
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44219-6

Bis-Cycloruthenated Complexes in Visible Light-Induced C–H Alkylation with Epoxides

Author(s): Kurt Bentley, Mishra Deepak Hareram, Gang-Wei Wang, Alexander A. V. Millman, Ignacio Perez-Ortega, Luke M. Nichols, Cassandre C. Bories, Lauren E. Walker, Adam W. Woodward, Alexander P. Golovanov, Louise S. Natrajan, Igor Larrosa
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 5035-5042, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c14835

Catalysis with cycloruthenated complexes

Author(s): Michael T. Findlay, Pablo Domingo-Legarda, Gillian McArthur, Andy Yen, Igor Larrosa
Published in: Chemical Science, 2022, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc06355c

Organic reaction mechanism classification using machine learning

Author(s): Jordi Burés; Igor Larrosa
Published in: Nature, Issue 1, 2023, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-022-05639-4

Engineered enzymes for enantioselective nucleophilic aromatic substitutions

Author(s): Thomas M. Lister, George W. Roberts, Euan J. Hossack, Fei Zhao, Ashleigh J. Burke, Linus O. Johannissen, Florence J. Hardy, Alexander A. V. Millman, David Leys, Igor Larrosa, Anthony P. Green
Published in: Nature, Issue 639, 2025, Page(s) 375-381, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-08611-0