Project description
A sustainable route to the production of small molecular building blocks
The ability to readily access small molecular building blocks at will has important implications for the discovery and development of novel medicines and materials. Efficient catalytic processes that are easily executed and utilise readily available starting materials open up an environmentally benign route to the production of optically active products with high regioselectivity, chemoselectivity, diastereoselectivity and enantioselectivity. The EU-funded OLECAT project plans to develop and study a collection of olefin functionalisation reactions that provide access to useful building blocks. These include amines, azides, hydrazines, nitriles and alcohols. The catalyst will be derived from earth-abundant materials, such as iron, manganese and cobalt, and will incorporate novel chiral ligands.
Objective
The ability toThe ability to readily access small-molecule building blocks at will has important consequences for the discovery and development of novel medicines and materials. It is particularly beneficial when the chemical methods are convenient while at the same time economically and environmentally tenable and sustainable. We are especially interested in catalytic processes that are easily executed and utilize readily available starting materials to produce optically active products with high regio, chemo, diastereo, and enantioselectivity.
The proposal aims to discover, develop, and study a collection of enantioselective olefin functionalization reactions that provide access to useful building blocks, such as amines, azides, hydrazines, nitriles, alcohols, involving acyclic, cyclic and bicyclic structures. The catalyst will be derived from earth abundant metals, such as Fe, Mn, and Co and incorporate novel chiral ligands. The study includes the design and preparation of two structural classes of novel, chiral boric acids that are expected to serve as catalyst for the enantioselective functionalization of unsaturated carboxylic acids and boronic acids.
The methods are expected to substantially impact the development of novel strategies for complex molecule synthesis. In this regard, we propose to use the catalysts form this study to convert dienes and trienes into polyols with characteristic stereochemical and oxidation patterns found in bioactive agents, including pharma- and nutraceuticals (carnitine). Such advances enable new approaches that go beyond the well-established methods such as aldol/allylation for the preparation of stereochemically complex fragments. Catalysts will also be developed that convert acyclic olefinic alcohols and amines into optically active, saturated furans, pyrans, pyrrolidines, and piperidines. The implementation of the various catalytic methods in complex settings enables efficient, convergent routes to bioactive agents.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2018-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.