Drosophila sechellia: a novel model to investigate nervous system and behavioral evolution

Project Information

NEUROFLIES

Grant agreement ID: 833548

DOI

10.3030/833548

Project closed

EC signature date 8 April 2019

Start date 1 October 2019

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 327 547,00

EU contribution

€ 2 327 547,00

Coordinated by

UNIVERSITE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Peer reviewed articles (24)

Copy number changes in co-expressed odorant receptor genes enable selection for sensory differences in drosophilid species

Author(s): Thomas O. Auer, Raquel Álvarez-Ocaña, Steeve Cruchet, Richard Benton, J. Roman Arguello
Published in: Nature Ecology & Evolution, Issue 6, 2022, Page(s) 1343-1353, ISSN 2397-334X
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41559-022-01830-y

Odor-regulated oviposition behavior in an ecological specialist

Author(s): Raquel Álvarez-Ocaña, Michael P. Shahandeh, Vijayaditya Ray, Thomas O. Auer, Nicolas Gompel, Richard Benton
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38722-z

Olfactory receptor–dependent receptor repression in Drosophila

Author(s): Kaan Mika, Steeve Cruchet, Phing Chian Chai, Lucia L. Prieto-Godino, Thomas O. Auer, Sylvain Pradervand, Richard Benton
Published in: Science Advances, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abe3745

Functional integration of “undead” neurons in the olfactory system

Author(s): Lucia L. Prieto-Godino, Ana F. Silbering, Mohammed A. Khallaf, Steeve Cruchet, Karolina Bojkowska, Sylvain Pradervand, Bill S. Hansson, Markus Knaden, Richard Benton
Published in: Science Advances, Issue 6/11, 2020, Page(s) eaaz7238, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aaz7238

Olfactory receptor and circuit evolution promote host specialization

Author(s): Thomas O. Auer, Mohammed A. Khallaf, Ana F. Silbering, Giovanna Zappia, Kaitlyn Ellis, Raquel Álvarez-Ocaña, J. Roman Arguello, Bill S. Hansson, Gregory S. X. E. Jefferis, Sophie J. C. Caron, Markus Knaden, Richard Benton
Published in: Nature, Issue 579/7799, 2020, Page(s) 402-408, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2073-7

Molecular mechanisms of olfactory detection in insects: beyond receptors

Author(s): Hayden R. Schmidt, Richard Benton
Published in: Open Biology, Issue 10/10, 2020, Page(s) 200252, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.200252

Olfactory receptor gene regulation in insects: multiple mechanisms for singular expression

Author(s): Kaan Mika, Richard Benton
Published in: Frontiers in Neuroscience, 2021, ISSN 1662-453X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fnins.2021.738088

Remote homolog detection places insect chemoreceptors in a cryptic protein superfamily spanning the tree of life

Author(s): Nathaniel J. Himmel, David Moi, Richard Benton
Published in: Current Biology, Issue 33, 2024, Page(s) 5023-5033.e4, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2023.10.008

A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor

Author(s): Richard Benton, Christophe Dessimoz, David Moi
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.62507

Drosophila sechellia: A Genetic Model for Behavioral Evolution and Neuroecology

Author(s): Thomas O. Auer, Michael P. Shahandeh, RIchard Benton
Published in: Annual Review of Genetics, 2021, ISSN 1545-2948
Publisher: Annual Reviews
DOI: 10.1146/annurev-genet-071719-020719

Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins

Author(s): Richard Benton, Nathaniel J Himmel
Published in: eLife, Issue 12, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.85537

<i>Drosophila</i> olfaction: past, present and future

Author(s): Richard Benton
Published in: Proceedings of the Royal Society B: Biological Sciences, Issue 289, 2023, ISSN 0962-8452
Publisher: Royal Society of London
DOI: 10.1098/rspb.2022.2054

Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants

Author(s): J Roman Arguello, Liliane Abuin, Jan Armida, Kaan Mika, Phing Chian Chai, Richard Benton
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.63036

Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration

Author(s): Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Yuko Maejima, Kenju Shimomura, Hiroshi Mizuma, Aya Mawatari, Hisashi Doi, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Makoto Osanai, Takuma Nishijo, Toshihiko Momiyama, Richard Benton, Kazuto Kobayashi
Published in: Communications Biology, Issue 7, 2024, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-06223-4

Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking

Author(s): Suguru Takagi, Gizem Sancer, Liliane Abuin, S. David Stupski, J. Roman Arguello, Lucia L. Prieto-Godino, David L. Stern, Steeve Cruchet, Raquel Álvarez-Ocaña, Carl F. R. Wienecke, Floris van Breugel, James M. Jeanne, Thomas O. Auer, Richard Benton
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-50808-w

Pheromone sensing in Drosophila requires support cell-expressed Osiris 8

Author(s): Marta Scalzotto, Renny Ng, Steeve Cruchet, Michael Saina, Jan Armida, Chih-Ying Su, Richard Benton
Published in: BMC Biology, Issue 20, 2022, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-022-01425-w

Enhanced Retrieval of Taste Associative Memory by Chemogenetic Activation of Locus Coeruleus Norepinephrine Neurons

Author(s): Ryoji Fukabori, Yoshio Iguchi, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Shingo Tsuji, Akihiro Hazama, Motokazu Uchigashima, Masahiko Watanabe, Hiroshi Mizuma, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Yasunobu Yasoshima, Makoto Osanai, Ryo Inagaki, Kohji Fukunaga, Takuma Nishijo, Toshihiko Momiyama, Richard Benton, Kazuto Kobayashi
Published in: The Journal of Neuroscience, Issue 40/43, 2020, Page(s) 8367-8385, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.1720-20.2020

Molecular reconstruction of recurrent evolutionary switching in olfactory receptor specificity

Author(s): Lucia L. Prieto-Godino, Hayden R. Schmidt, Richard Benton
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.69732

Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation

Author(s): Daehan Lee, Michael P. Shahandeh, Liliane Abuin, Richard Benton
Published in: PLOS Biology, Issue 23, 2025, Page(s) e3003120, ISSN 1545-7885
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pbio.3003120

Mate discrimination among subspecies through a conserved olfactory pathway

Author(s): Mohammed A. Khallaf, Thomas O. Auer, Veit Grabe, Ana Depetris-Chauvin, Byrappa Ammagarahalli, Dan-Dan Zhang, Sofía Lavista-Llanos, Filip Kaftan, Jerrit Weißflog, Luciano M. Matzkin, Stephanie M. Rollmann, Christer Löfstedt, Aleš Svatoš, Hany K. M. Dweck, Silke Sachse, Richard Benton, Bill S. Hansson, Markus Knaden
Published in: Science Advances, Issue 6/25, 2020, Page(s) eaba5279, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aba5279

A chemogenetic technology using insect Ionotropic Receptors to stimulate target cell populations in the mammalian brain

Author(s): Yoshio Iguchi, Richard Benton, Kazuto Kobayashi
Published in: Neuroscience Research, 2024, ISSN 0168-0102
Publisher: Elsevier BV
DOI: 10.1016/j.neures.2024.11.003

Olfactory projection neuron rewiring in the brain of an ecological specialist

Author(s): Benedikt R. Dürr, Enrico Bertolini, Suguru Takagi, Justine Pascual, Liliane Abuin, Giovanna Lucarelli, Richard Benton, Thomas O. Auer
Published in: Cell Reports, Issue 44, 2025, Page(s) 115615, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2025.115615

Circadian plasticity evolves through regulatory changes in a neuropeptide gene

Author(s): Michael P. Shahandeh, Liliane Abuin, Lou Lescuyer De Decker, Julien Cergneux, Rafael Koch, Emi Nagoshi, Richard Benton
Published in: Nature, Issue 635, 2024, Page(s) 951-959, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-08056-x

Evolution of connectivity architecture in the Drosophila mushroom body

Author(s): Kaitlyn Elizabeth Ellis, Sven Bervoets, Hayley Smihula, Ishani Ganguly, Eva Vigato, Thomas O. Auer, Richard Benton, Ashok Litwin-Kumar, Sophie Jeanne Cécile Caron
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-48839-4

Non-peer reviewed articles (1)

Sweet sensors support stressed cell survival

Author(s): Nathaniel J. Himmel, Richard Benton
Published in: PLOS Biology, Issue 20, 2022, Page(s) e3001705, ISSN 1545-7885
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pbio.3001705

Other (2)

An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system

Author(s): Richard Benton, Jérôme Mermet, Andre Jang, Keita Endo, Steeve Cruchet, Karen Menuz
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.16.632927

Multilayer regulation underlies the functional precision and evolvability of the olfactory system

Author(s): Jérôme Mermet, Steeve Cruchet, Asfa Sabrin Borbora, Daehan Lee, Phing Chian Chai, Andre Jang, Karen Menuz, Richard Benton
Published in: bioRxiv, 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.16.632932