Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma

Project Information

T-NHL SUPRESSORS

Grant agreement ID: 834154

DOI 10.3030/834154

EC signature date 4 June 2019

Start date 1 December 2019

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 492 937,50

EU contribution € 2 492 937,50

Coordinated by

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany

Publications

Peer reviewed articles (11)

The fusion oncogene VAV1-MYO1F triggers aberrant T-cell receptor signalling in vivo and drives peripheral T-cell lymphoma in mice

Author(s): Morrish, E., Wartewig, T., Kratzert, A., Rosenbaum, M., Steiger, K., Ruland, J.
Published in: European Journal of Immunology, 2022, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250147

Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation

Author(s): Zsuzsanna Kurgyis, Larsen Vornholz, Konstanze Pechloff, Lajos V. Kemény, Tim Wartewig, Andreas Muschaweckh, Abhinav Joshi, Katja Kranen, Lara Hartjes, Sigrid Möckel, Katja Steiger, Erik Hameister, Thomas Volz, Mark Mellett, Lars E. French, Tilo Biedermann, Thomas Korn & Jürgen Ruland
Published in: Science Immunology, 2021, ISSN 2470-9468
Publisher: AAAS
DOI: 10.1126/sciimmunol.abi4425

Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia

Author(s): Kerle, I.A., Jagerhuber, L., Secci, R., Pfarr, N., Blum, P., Roesch, R., Gotze, K.S., Weichert, W., Bassermann, F., Ruland, J., Winter, C.
Published in: Cancers (Basel), 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061371

Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression

Author(s): Tanja Groll; Miguel Silva; Rim Sabrina Jahan Sarker; Markus Tschurtschenthaler; Theresa Schnalzger; Carolin Mogler; Daniela Denk; Sebastian Schölch; Barbara U. Schraml; Jürgen Ruland; Roland Rad; Dieter Saur; Wilko Weichert; Moritz Jesinghaus; Kaspar Matiasek; Katja Steiger
Published in: Cancers; Volume 14; Issue 9; Pages: 2248, Issue 1, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092248

T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer

Author(s): Xue, B., von Heyking, K., Gassmann, H., Poorebrahim, M., Thiede, M., Schober, K., Mautner, J., Hauer, J., Ruland, J., Busch, D.H., Thiel, U., Burdach, S.E.G.
Published in: Cancers (Basel), 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14225485

The molecular ontogeny of follicular lymphoma: Gene mutations succeeding the <em>BCL2</em> translocation define common precursor cells.

Author(s): Sarah Haebe; William Keay; Stefan Alig; Anne‐Wiebe Mohr; Larissa K. Martin; Michael Heide; Ramona Secci; Stefan Krebs; Helmut Blum; Andreas Moosmann; Abner Louissaint; David M. Weinstock; Silvia Thoene; Michael Bergwelt‐Baildon; Jürgen Ruland; Deepak Bararia; Oliver Weigert
Published in: Br. J. Haematol., DOI: 10.1111/bjh.17990 (2021), Issue 1, 2021, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.17990

Cytotoxic FCER1G+ innate-like T cells: new potential for tumour immunotherapy

Author(s): Emma Morrish & Jürgen Ruland
Published in: Signal Transduction and Targeted Therapy, 2022, ISSN 2095-9907
Publisher: Nature Research
DOI: 10.1038/s41392-022-01061-4

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia

Author(s): Begüm Alankus, Veronika Ecker, Nathalie Vahl, Martina Braun, Wilko Weichert, Stephan Macher-Göppinger, Torben Gehring, Tanja Neumayer, Thorsten Zenz, Maike Buchner, Jürgen Ruland
Published in: Journal of Experimental Medicine, Issue 218/2, 2021, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20200517

MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion

Author(s): Marc Rosenbaum, Theresa Schnalzger, Thomas Engleitner, Christin Weiß, Ritu Mishra, Cora Mibus, Theresa Mitterer, Roland Rad, Jürgen Ruland
Published in: European Journal of Immunology, 2021, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202149355

S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis

Author(s): Mariano Prado Acosta, Guillaume Goyette-Desjardins, Jörg Scheffel, Anne Dudeck, Jürgen Ruland, Bernd Lepenies
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.602067

Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity

Author(s): Park, J., Daniels, J., Wartewig, T., Ringbloom, K.G., Martinez-Escala, M.E., Choi, S., Thomas, J.J., Doukas, P.G., Yang, J., Snowden, C., Law, C., Lee, Y., Lee, K., Zhang, Y., Conran, C., Tegtmeyer, K., Mo, S.H., Pease, D.R., Jothishankar, B., Kwok, P.Y., Abdulla, F.R., Pro, B., Louissaint, A., Boggon, T., Sosman, J., Guitart, J., Rao, D.A., Ruland, J.*, Choi, J.*
Published in: Blood, 2021, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020009655

Book chapters (1)

Physiological and Pathological Functions of CARD9 Signaling in the Innate Immune System

Author(s): Larsen Vornholz, Jürgen Ruland
Published in: C-Type Lectins in Immune Homeostasis, Issue 429, 2020, Page(s) 177-203, ISBN 978-3-030-62236-7
Publisher: Springer International Publishing
DOI: 10.1007/82_2020_211