Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma

Informazioni relative al progetto

T-NHL SUPRESSORS

ID dell’accordo di sovvenzione: 834154

DOI

10.3030/834154

Progetto chiuso

Data della firma CE 4 Giugno 2019

Data di avvio 1 Dicembre 2019

Data di completamento 30 Novembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 492 937,50

Contributo UE

€ 2 492 937,50

Coordinato da

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (20)

Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy

Autori: Vornholz, L., Isay, S.E., Kurgyis, Z., Strobl, D.C., Loll, P., Mosa, M.H., Luecken, M.D., Sterr, M., Lickert, H., Winter, C., Greten, F.R., Farin, H.F., Theis, F.J., Ruland, J.
Pubblicato in: Science Advances, 2023, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.add8564

Harnessing naturally occurring mutations for T-cell therapy: a potential new avenue to enhance treatment efficacy

Autori: Michael Hiltensperger, Jürgen Ruland, Kilian Schober
Pubblicato in: Signal Transduction and Targeted Therapy, Numero 9, 2024, ISSN 2059-3635
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41392-024-01835-y

The fusion oncogene VAV1-MYO1F triggers aberrant T-cell receptor signalling in vivo and drives peripheral T-cell lymphoma in mice

Autori: Morrish, E., Wartewig, T., Kratzert, A., Rosenbaum, M., Steiger, K., Ruland, J.
Pubblicato in: European Journal of Immunology, 2022, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250147

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

Autori: H. Theobald, D. A. Bejarano, N. Katzmarski, J. Haub, J. Schulte-Schrepping, J. Yu, K. Bassler, A. L. Ament, C. Osei-Sarpong, F. Piattini, L. Vornholz, W. T’Jonck, A. H. Györfi, H. Hayer, X. Yu, S.
Pubblicato in: Nature Immunology, Numero 25, 2024, Pagina/e 994-1006, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-024-01830-z

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors

Autori: Maria Reinecke, Paul Brear, Larsen Vornholz, Benedict-Tilmann Berger, Florian Seefried, Stephanie Wilhelm, Patroklos Samaras, Laszlo Gyenis, David William Litchfield, Guillaume Médard, Susanne Mülle
Pubblicato in: Nature Chemical Biology, Numero 20, 2024, Pagina/e 577-585, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-023-01459-3

Enforced CARD11/MALT1 signaling in dendritic cells triggers hemophagocytic lymphohistiocytosis

Autori: Sophie E. Isay, Larsen Vornholz, Theresa Schnalzger, Tanja Groll, Thomas Magg, Patricia Loll, Gregor Weirich, Katja Steiger, Fabian Hauck, Jürgen Ruland
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 121, 2024, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2413162121

PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma

Autori: Wartewig, T., Daniels, J., Schulz, M., Hameister, E., Joshi, A., Park, J., Morrish, E., Venkatasubramani, A.V., Cernilogar, F.M., van Heijster, F.H.A., Hundshammer, C., Schneider, H., Konstantinidis, F., Gabler, J.V., Klement, C., Kurniawan, H., Law, C., Lee, Y., Choi, S., Guitart, J., Forne, I., Giustinani, J., Muschen, M., Jain, S., Weinstock, D.M., Rad, R., Ortonne, N., Schilling, F., Schotta,
Pubblicato in: Nature Cancer, 2023, ISSN 2662-1347
Editore: Nature
DOI: 10.1038/s43018-023-00635-7

Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation

Autori: Zsuzsanna Kurgyis, Larsen Vornholz, Konstanze Pechloff, Lajos V. Kemény, Tim Wartewig, Andreas Muschaweckh, Abhinav Joshi, Katja Kranen, Lara Hartjes, Sigrid Möckel, Katja Steiger, Erik Hameister, Thomas Volz, Mark Mellett, Lars E. French, Tilo Biedermann, Thomas Korn & Jürgen Ruland
Pubblicato in: Science Immunology, 2021, ISSN 2470-9468
Editore: AAAS
DOI: 10.1126/sciimmunol.abi4425

Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia

Autori: Kerle, I.A., Jagerhuber, L., Secci, R., Pfarr, N., Blum, P., Roesch, R., Gotze, K.S., Weichert, W., Bassermann, F., Ruland, J., Winter, C.
Pubblicato in: Cancers (Basel), 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061371

Alpha1-antitrypsin impacts innate host–pathogen interactions with <i>Candida albicans</i> by stimulating fungal filamentation

Autori: Martin Jaeger, Axel Dietschmann, Sophie Austermeier, Sude Dinçer, Pauline Porschitz, Larsen Vornholz, Ralph J.A. Maas, Evelien G.G. Sprenkeler, Jürgen Ruland, Stefan Wirtz, Tania Azam, Leo A.B. Joos
Pubblicato in: Virulence, Numero 15, 2025, ISSN 2150-5594
Editore: Landes Bioscience
DOI: 10.1080/21505594.2024.2333367

Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression

Autori: Tanja Groll; Miguel Silva; Rim Sabrina Jahan Sarker; Markus Tschurtschenthaler; Theresa Schnalzger; Carolin Mogler; Daniela Denk; Sebastian Schölch; Barbara U. Schraml; Jürgen Ruland; Roland Rad; Dieter Saur; Wilko Weichert; Moritz Jesinghaus; Kaspar Matiasek; Katja Steiger
Pubblicato in: Cancers; Volume 14; Numero 9; Pages: 2248, Numero 1, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092248

T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer

Autori: Xue, B., von Heyking, K., Gassmann, H., Poorebrahim, M., Thiede, M., Schober, K., Mautner, J., Hauer, J., Ruland, J., Busch, D.H., Thiel, U., Burdach, S.E.G.
Pubblicato in: Cancers (Basel), 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14225485

Activation of gp130 signaling in T cells drives T _H 17-mediated multi-organ autoimmunity

Autori: Francis Baumgartner, Stefanos A. Bamopoulos, Laura Faletti, Hsiang-Jung Hsiao, Maximilian Holz, Irene Gonzalez-Menendez, Llorenç Boldo, Arik Horne, Sanket Gosavi, Ceren Özerdem, Nikita Singh, Sven L
Pubblicato in: Science Signaling, Numero 17, 2024, ISSN 1937-9145
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.adc9662

The molecular ontogeny of follicular lymphoma: Gene mutations succeeding the <em>BCL2</em> translocation define common precursor cells.

Autori: Sarah Haebe; William Keay; Stefan Alig; Anne‐Wiebe Mohr; Larissa K. Martin; Michael Heide; Ramona Secci; Stefan Krebs; Helmut Blum; Andreas Moosmann; Abner Louissaint; David M. Weinstock; Silvia Thoene; Michael Bergwelt‐Baildon; Jürgen Ruland; Deepak Bararia; Oliver Weigert
Pubblicato in: Br. J. Haematol., DOI: 10.1111/bjh.17990 (2021), Numero 1, 2021, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.17990

Cytotoxic FCER1G+ innate-like T cells: new potential for tumour immunotherapy

Autori: Emma Morrish & Jürgen Ruland
Pubblicato in: Signal Transduction and Targeted Therapy, 2022, ISSN 2095-9907
Editore: Nature Research
DOI: 10.1038/s41392-022-01061-4

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia

Autori: Begüm Alankus, Veronika Ecker, Nathalie Vahl, Martina Braun, Wilko Weichert, Stephan Macher-Göppinger, Torben Gehring, Tanja Neumayer, Thorsten Zenz, Maike Buchner, Jürgen Ruland
Pubblicato in: Journal of Experimental Medicine, Numero 218/2, 2021, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20200517

MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion

Autori: Marc Rosenbaum, Theresa Schnalzger, Thomas Engleitner, Christin Weiß, Ritu Mishra, Cora Mibus, Theresa Mitterer, Roland Rad, Jürgen Ruland
Pubblicato in: European Journal of Immunology, 2021, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202149355

S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis

Autori: Mariano Prado Acosta, Guillaume Goyette-Desjardins, Jörg Scheffel, Anne Dudeck, Jürgen Ruland, Bernd Lepenies
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.602067

Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity

Autori: Park, J., Daniels, J., Wartewig, T., Ringbloom, K.G., Martinez-Escala, M.E., Choi, S., Thomas, J.J., Doukas, P.G., Yang, J., Snowden, C., Law, C., Lee, Y., Lee, K., Zhang, Y., Conran, C., Tegtmeyer, K., Mo, S.H., Pease, D.R., Jothishankar, B., Kwok, P.Y., Abdulla, F.R., Pro, B., Louissaint, A., Boggon, T., Sosman, J., Guitart, J., Rao, D.A., Ruland, J.*, Choi, J.*
Pubblicato in: Blood, 2021, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020009655

B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation

Autori: Iana Gadjalova; Julia M. Heinze; Marie C. Goess; Julian Hofmann; Annalisa Buck; Marie-Christin Weber; Birgit Blissenbach; Maximilian Kampick; Oleg Krut; Katja Steiger; Klaus-Peter Janssen; Philipp-Alexander Neumann; Jürgen Ruland; Selina J. Keppler
Pubblicato in: Crossref, Numero 1, 2024, ISSN 1933-0219
Editore: Nature Publishing Group
DOI: 10.1016/j.mucimm.2023.10.005

Book chapters (1)

Physiological and Pathological Functions of CARD9 Signaling in the Innate Immune System

Autori: Larsen Vornholz, Jürgen Ruland
Pubblicato in: C-Type Lectins in Immune Homeostasis, Numero 429, 2020, Pagina/e 177-203, ISBN 978-3-030-62236-7
Editore: Springer International Publishing
DOI: 10.1007/82_2020_211