Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma

Informazioni relative al progetto

T-NHL SUPRESSORS

ID dell’accordo di sovvenzione: 834154

DOI 10.3030/834154

Data della firma CE 4 Giugno 2019

Data di avvio 1 Dicembre 2019

Data di completamento 30 Novembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 492 937,50

Contributo UE € 2 492 937,50

Coordinato da

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany

Pubblicazioni

Peer reviewed articles (11)

The fusion oncogene VAV1-MYO1F triggers aberrant T-cell receptor signalling in vivo and drives peripheral T-cell lymphoma in mice

Autori: Morrish, E., Wartewig, T., Kratzert, A., Rosenbaum, M., Steiger, K., Ruland, J.
Pubblicato in: European Journal of Immunology, 2022, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250147

Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation

Autori: Zsuzsanna Kurgyis, Larsen Vornholz, Konstanze Pechloff, Lajos V. Kemény, Tim Wartewig, Andreas Muschaweckh, Abhinav Joshi, Katja Kranen, Lara Hartjes, Sigrid Möckel, Katja Steiger, Erik Hameister, Thomas Volz, Mark Mellett, Lars E. French, Tilo Biedermann, Thomas Korn & Jürgen Ruland
Pubblicato in: Science Immunology, 2021, ISSN 2470-9468
Editore: AAAS
DOI: 10.1126/sciimmunol.abi4425

Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia

Autori: Kerle, I.A., Jagerhuber, L., Secci, R., Pfarr, N., Blum, P., Roesch, R., Gotze, K.S., Weichert, W., Bassermann, F., Ruland, J., Winter, C.
Pubblicato in: Cancers (Basel), 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061371

Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression

Autori: Tanja Groll; Miguel Silva; Rim Sabrina Jahan Sarker; Markus Tschurtschenthaler; Theresa Schnalzger; Carolin Mogler; Daniela Denk; Sebastian Schölch; Barbara U. Schraml; Jürgen Ruland; Roland Rad; Dieter Saur; Wilko Weichert; Moritz Jesinghaus; Kaspar Matiasek; Katja Steiger
Pubblicato in: Cancers; Volume 14; Numero 9; Pages: 2248, Numero 1, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092248

T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer

Autori: Xue, B., von Heyking, K., Gassmann, H., Poorebrahim, M., Thiede, M., Schober, K., Mautner, J., Hauer, J., Ruland, J., Busch, D.H., Thiel, U., Burdach, S.E.G.
Pubblicato in: Cancers (Basel), 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14225485

The molecular ontogeny of follicular lymphoma: Gene mutations succeeding the <em>BCL2</em> translocation define common precursor cells.

Autori: Sarah Haebe; William Keay; Stefan Alig; Anne‐Wiebe Mohr; Larissa K. Martin; Michael Heide; Ramona Secci; Stefan Krebs; Helmut Blum; Andreas Moosmann; Abner Louissaint; David M. Weinstock; Silvia Thoene; Michael Bergwelt‐Baildon; Jürgen Ruland; Deepak Bararia; Oliver Weigert
Pubblicato in: Br. J. Haematol., DOI: 10.1111/bjh.17990 (2021), Numero 1, 2021, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.17990

Cytotoxic FCER1G+ innate-like T cells: new potential for tumour immunotherapy

Autori: Emma Morrish & Jürgen Ruland
Pubblicato in: Signal Transduction and Targeted Therapy, 2022, ISSN 2095-9907
Editore: Nature Research
DOI: 10.1038/s41392-022-01061-4

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia

Autori: Begüm Alankus, Veronika Ecker, Nathalie Vahl, Martina Braun, Wilko Weichert, Stephan Macher-Göppinger, Torben Gehring, Tanja Neumayer, Thorsten Zenz, Maike Buchner, Jürgen Ruland
Pubblicato in: Journal of Experimental Medicine, Numero 218/2, 2021, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20200517

MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion

Autori: Marc Rosenbaum, Theresa Schnalzger, Thomas Engleitner, Christin Weiß, Ritu Mishra, Cora Mibus, Theresa Mitterer, Roland Rad, Jürgen Ruland
Pubblicato in: European Journal of Immunology, 2021, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202149355

S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis

Autori: Mariano Prado Acosta, Guillaume Goyette-Desjardins, Jörg Scheffel, Anne Dudeck, Jürgen Ruland, Bernd Lepenies
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.602067

Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity

Autori: Park, J., Daniels, J., Wartewig, T., Ringbloom, K.G., Martinez-Escala, M.E., Choi, S., Thomas, J.J., Doukas, P.G., Yang, J., Snowden, C., Law, C., Lee, Y., Lee, K., Zhang, Y., Conran, C., Tegtmeyer, K., Mo, S.H., Pease, D.R., Jothishankar, B., Kwok, P.Y., Abdulla, F.R., Pro, B., Louissaint, A., Boggon, T., Sosman, J., Guitart, J., Rao, D.A., Ruland, J.*, Choi, J.*
Pubblicato in: Blood, 2021, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020009655

Book chapters (1)

Physiological and Pathological Functions of CARD9 Signaling in the Innate Immune System

Autori: Larsen Vornholz, Jürgen Ruland
Pubblicato in: C-Type Lectins in Immune Homeostasis, Numero 429, 2020, Pagina/e 177-203, ISBN 978-3-030-62236-7
Editore: Springer International Publishing
DOI: 10.1007/82_2020_211