Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma

Información del proyecto

T-NHL SUPRESSORS

Identificador del acuerdo de subvención: 834154

DOI

10.3030/834154

Proyecto cerrado

Fecha de la firma de la CE 4 Junio 2019

Fecha de inicio 1 Diciembre 2019

Fecha de finalización 30 Noviembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 492 937,50

Aportación de la UE

€ 2 492 937,50

Coordinado por

KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (20)

Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy

Autores: Vornholz, L., Isay, S.E., Kurgyis, Z., Strobl, D.C., Loll, P., Mosa, M.H., Luecken, M.D., Sterr, M., Lickert, H., Winter, C., Greten, F.R., Farin, H.F., Theis, F.J., Ruland, J.
Publicado en: Science Advances, 2023, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.add8564

Harnessing naturally occurring mutations for T-cell therapy: a potential new avenue to enhance treatment efficacy

Autores: Michael Hiltensperger, Jürgen Ruland, Kilian Schober
Publicado en: Signal Transduction and Targeted Therapy, Edición 9, 2024, ISSN 2059-3635
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41392-024-01835-y

The fusion oncogene VAV1-MYO1F triggers aberrant T-cell receptor signalling in vivo and drives peripheral T-cell lymphoma in mice

Autores: Morrish, E., Wartewig, T., Kratzert, A., Rosenbaum, M., Steiger, K., Ruland, J.
Publicado en: European Journal of Immunology, 2022, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250147

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

Autores: H. Theobald, D. A. Bejarano, N. Katzmarski, J. Haub, J. Schulte-Schrepping, J. Yu, K. Bassler, A. L. Ament, C. Osei-Sarpong, F. Piattini, L. Vornholz, W. T’Jonck, A. H. Györfi, H. Hayer, X. Yu, S.
Publicado en: Nature Immunology, Edición 25, 2024, Página(s) 994-1006, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-024-01830-z

Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors

Autores: Maria Reinecke, Paul Brear, Larsen Vornholz, Benedict-Tilmann Berger, Florian Seefried, Stephanie Wilhelm, Patroklos Samaras, Laszlo Gyenis, David William Litchfield, Guillaume Médard, Susanne Mülle
Publicado en: Nature Chemical Biology, Edición 20, 2024, Página(s) 577-585, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-023-01459-3

Enforced CARD11/MALT1 signaling in dendritic cells triggers hemophagocytic lymphohistiocytosis

Autores: Sophie E. Isay, Larsen Vornholz, Theresa Schnalzger, Tanja Groll, Thomas Magg, Patricia Loll, Gregor Weirich, Katja Steiger, Fabian Hauck, Jürgen Ruland
Publicado en: Proceedings of the National Academy of Sciences, Edición 121, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2413162121

PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma

Autores: Wartewig, T., Daniels, J., Schulz, M., Hameister, E., Joshi, A., Park, J., Morrish, E., Venkatasubramani, A.V., Cernilogar, F.M., van Heijster, F.H.A., Hundshammer, C., Schneider, H., Konstantinidis, F., Gabler, J.V., Klement, C., Kurniawan, H., Law, C., Lee, Y., Choi, S., Guitart, J., Forne, I., Giustinani, J., Muschen, M., Jain, S., Weinstock, D.M., Rad, R., Ortonne, N., Schilling, F., Schotta,
Publicado en: Nature Cancer, 2023, ISSN 2662-1347
Editor: Nature
DOI: 10.1038/s43018-023-00635-7

Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation

Autores: Zsuzsanna Kurgyis, Larsen Vornholz, Konstanze Pechloff, Lajos V. Kemény, Tim Wartewig, Andreas Muschaweckh, Abhinav Joshi, Katja Kranen, Lara Hartjes, Sigrid Möckel, Katja Steiger, Erik Hameister, Thomas Volz, Mark Mellett, Lars E. French, Tilo Biedermann, Thomas Korn & Jürgen Ruland
Publicado en: Science Immunology, 2021, ISSN 2470-9468
Editor: AAAS
DOI: 10.1126/sciimmunol.abi4425

Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia

Autores: Kerle, I.A., Jagerhuber, L., Secci, R., Pfarr, N., Blum, P., Roesch, R., Gotze, K.S., Weichert, W., Bassermann, F., Ruland, J., Winter, C.
Publicado en: Cancers (Basel), 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14061371

Alpha1-antitrypsin impacts innate host–pathogen interactions with <i>Candida albicans</i> by stimulating fungal filamentation

Autores: Martin Jaeger, Axel Dietschmann, Sophie Austermeier, Sude Dinçer, Pauline Porschitz, Larsen Vornholz, Ralph J.A. Maas, Evelien G.G. Sprenkeler, Jürgen Ruland, Stefan Wirtz, Tania Azam, Leo A.B. Joos
Publicado en: Virulence, Edición 15, 2025, ISSN 2150-5594
Editor: Landes Bioscience
DOI: 10.1080/21505594.2024.2333367

Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression

Autores: Tanja Groll; Miguel Silva; Rim Sabrina Jahan Sarker; Markus Tschurtschenthaler; Theresa Schnalzger; Carolin Mogler; Daniela Denk; Sebastian Schölch; Barbara U. Schraml; Jürgen Ruland; Roland Rad; Dieter Saur; Wilko Weichert; Moritz Jesinghaus; Kaspar Matiasek; Katja Steiger
Publicado en: Cancers; Volume 14; Edición 9; Pages: 2248, Edición 1, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14092248

T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer

Autores: Xue, B., von Heyking, K., Gassmann, H., Poorebrahim, M., Thiede, M., Schober, K., Mautner, J., Hauer, J., Ruland, J., Busch, D.H., Thiel, U., Burdach, S.E.G.
Publicado en: Cancers (Basel), 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14225485

Activation of gp130 signaling in T cells drives T _H 17-mediated multi-organ autoimmunity

Autores: Francis Baumgartner, Stefanos A. Bamopoulos, Laura Faletti, Hsiang-Jung Hsiao, Maximilian Holz, Irene Gonzalez-Menendez, Llorenç Boldo, Arik Horne, Sanket Gosavi, Ceren Özerdem, Nikita Singh, Sven L
Publicado en: Science Signaling, Edición 17, 2024, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.adc9662

The molecular ontogeny of follicular lymphoma: Gene mutations succeeding the <em>BCL2</em> translocation define common precursor cells.

Autores: Sarah Haebe; William Keay; Stefan Alig; Anne‐Wiebe Mohr; Larissa K. Martin; Michael Heide; Ramona Secci; Stefan Krebs; Helmut Blum; Andreas Moosmann; Abner Louissaint; David M. Weinstock; Silvia Thoene; Michael Bergwelt‐Baildon; Jürgen Ruland; Deepak Bararia; Oliver Weigert
Publicado en: Br. J. Haematol., DOI: 10.1111/bjh.17990 (2021), Edición 1, 2021, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.17990

Cytotoxic FCER1G+ innate-like T cells: new potential for tumour immunotherapy

Autores: Emma Morrish & Jürgen Ruland
Publicado en: Signal Transduction and Targeted Therapy, 2022, ISSN 2095-9907
Editor: Nature Research
DOI: 10.1038/s41392-022-01061-4

Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia

Autores: Begüm Alankus, Veronika Ecker, Nathalie Vahl, Martina Braun, Wilko Weichert, Stephan Macher-Göppinger, Torben Gehring, Tanja Neumayer, Thorsten Zenz, Maike Buchner, Jürgen Ruland
Publicado en: Journal of Experimental Medicine, Edición 218/2, 2021, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20200517

MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion

Autores: Marc Rosenbaum, Theresa Schnalzger, Thomas Engleitner, Christin Weiß, Ritu Mishra, Cora Mibus, Theresa Mitterer, Roland Rad, Jürgen Ruland
Publicado en: European Journal of Immunology, 2021, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202149355

S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis

Autores: Mariano Prado Acosta, Guillaume Goyette-Desjardins, Jörg Scheffel, Anne Dudeck, Jürgen Ruland, Bernd Lepenies
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2021.602067

Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity

Autores: Park, J., Daniels, J., Wartewig, T., Ringbloom, K.G., Martinez-Escala, M.E., Choi, S., Thomas, J.J., Doukas, P.G., Yang, J., Snowden, C., Law, C., Lee, Y., Lee, K., Zhang, Y., Conran, C., Tegtmeyer, K., Mo, S.H., Pease, D.R., Jothishankar, B., Kwok, P.Y., Abdulla, F.R., Pro, B., Louissaint, A., Boggon, T., Sosman, J., Guitart, J., Rao, D.A., Ruland, J.*, Choi, J.*
Publicado en: Blood, 2021, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020009655

B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation

Autores: Iana Gadjalova; Julia M. Heinze; Marie C. Goess; Julian Hofmann; Annalisa Buck; Marie-Christin Weber; Birgit Blissenbach; Maximilian Kampick; Oleg Krut; Katja Steiger; Klaus-Peter Janssen; Philipp-Alexander Neumann; Jürgen Ruland; Selina J. Keppler
Publicado en: Crossref, Edición 1, 2024, ISSN 1933-0219
Editor: Nature Publishing Group
DOI: 10.1016/j.mucimm.2023.10.005

Book chapters (1)

Physiological and Pathological Functions of CARD9 Signaling in the Innate Immune System

Autores: Larsen Vornholz, Jürgen Ruland
Publicado en: C-Type Lectins in Immune Homeostasis, Edición 429, 2020, Página(s) 177-203, ISBN 978-3-030-62236-7
Editor: Springer International Publishing
DOI: 10.1007/82_2020_211