Targeting endothelial barriers to combat disease

Project Information

BreakingBarriers

Grant agreement ID: 834161

DOI

10.3030/834161

Project closed

EC signature date 4 June 2019

Start date 1 July 2019

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 969,00

EU contribution

€ 2 499 969,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Endothelial Unc5B control blood brain barrier integrity

Author(s): Boyé K, Geraldo LH, Furtado J, Pibouin-Fragner L, Poulet M, Kim D, Nelson B, Xu Y, Jacob L, Maissa N, Agalliu D, Claesson-Welsh L, Ackerman SL, Eichmann A
Published in: Nature Commun, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-28785-9

Conserved meningeal lymphatic drainage circuits in mice and humans

Author(s): Laurent Jacob, Jose de Brito Neto, Stephanie Lenck, Celine Corcy, Farhat Benbelkacem, Luiz Henrique Geraldo, Yunling Xu, Jean-Mickael Thomas, Marie-Renee El Kamouh, Myriam Spajer, Marie-Claude Potier, Stephane Haik, Michel Kalamarides, Bruno Stankoff, Stephane Lehericy, Anne Eichmann, Jean-Leon Thomas
Published in: Journal of Experimental Medicine, Issue 219, 2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20220035

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

Author(s): Ligia Simoes Braga Boisserand, Luiz Henrique Geraldo, Jean Bouchart, Marie-Renee El Kamouh, Seyoung Lee, Basavaraju G. Sanganahalli, Myriam Spajer, Shenqi Zhang, Sungwoon Lee, Maxime Parent, Yuechuan Xue, Mario Skarica, Xiangyun Yin, Justine Guegan, Kevin Boyé, Felipe Saceanu Leser, Laurent Jacob, Mathilde Poulet, Mingfeng Li, Xiaodan Liu, Sofia E. Velazquez, Ruchith Singhabahu, Mark E. Robinson,
Published in: Journal of Experimental Medicine, Issue 221, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20221983

Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood–retina barrier integrity

Author(s): Jessica Furtado, Luiz Henrique Geraldo, Felipe Saceanu Leser, Bartlomiej Bartkowiak, Mathilde Poulet, Hyojin Park, Mark Robinson, Laurence Pibouin-Fragner, Anne Eichmann, Kevin Boyé
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2408674121

Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression

Author(s): Jessica Furtado, Thomas E. Zapadka, Hyojin Park, Kevin Boyé, Jonathan B. Demb, Anne Eichmann
Published in: Cellular and Molecular Life Sciences, Issue 82, 2025, ISSN 1420-9071
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00018-025-05903-6

Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels

Author(s): Marie-Renee El Kamouh, Myriam Spajer, Ruchith Singhabahu, Anne-Laure Joly Marolany, Kurt A. Sailor, Laura Mouton, Diana Doukhi, Sunil Koundal, Tanner Metcalfe, Dominique Langui, Abel Grine, Kevin Boyé, Felipe Saceanu Leser, Justus Ninnemann, Joshua Gottschalk, Cyrus Sadeghi, Han Xu, Ligia Simoes Braga Boisserand, David Akbar, Jerome Van Wassenhove, Anthony Ruze, Amelle Nasri, Marie-Charlotte Bour
Published in: Nature Neuroscience, 2026, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-026-02358-1