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Targeting endothelial barriers to combat disease

Project description

Controlling migration across the body's internal borders to treat disease

The cells and tissues in the body act like little countries defending their borders, carefully controlling what goes in and out as an integral part of homeostasis and signalling. They can also coordinate activities. Among the allies in these functionally relevant synergies are blood and lymphatic vessels, critical for managing fluid flow. When the collaboration breaks down, it can lead to fluid build-up, chronic inflammation and even neurological and cardiovascular disease. BreakingBarriers is studying molecules that modulate the barriers in these two systems both in health and disease. Insight could provide novel ways to treat numerous diseases and conditions ranging from enhanced drug delivery to the brain to lowering lipid uptake to combat obesity.

Host institution

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 2 499 969,00
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00

Beneficiaries (1)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 2 499 969,00
Address
Rue De Tolbiac 101
75654 Paris

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00