Project description
Controlling migration across the body's internal borders to treat disease
The cells and tissues in the body act like little countries defending their borders, carefully controlling what goes in and out as an integral part of homeostasis and signalling. They can also coordinate activities. Among the allies in these functionally relevant synergies are blood and lymphatic vessels, critical for managing fluid flow. When the collaboration breaks down, it can lead to fluid build-up, chronic inflammation and even neurological and cardiovascular disease. BreakingBarriers is studying molecules that modulate the barriers in these two systems both in health and disease. Insight could provide novel ways to treat numerous diseases and conditions ranging from enhanced drug delivery to the brain to lowering lipid uptake to combat obesity.
Fields of science
- natural sciencesbiological sciencesneurobiology
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesclinical medicinecardiologycardiovascular diseases
- medical and health sciencesbasic medicinephysiologyhomeostasis
- medical and health scienceshealth sciencesnutritionobesity
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced GrantHost institution
75654 Paris
France
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Beneficiaries (1)
75654 Paris
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