Programmable ARTificial immune systems to fight cancer

Project Information

ARTimmune

Grant agreement ID: 834618

DOI

10.3030/834618

Project closed

EC signature date 5 June 2019

Start date 1 November 2019

End date 31 July 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Insights in the host response towards biomaterial-based scaffolds for cancer therapy

Author(s): Schluck, M., Weiden, J., Verdoes, M., and Figdor, C.G
Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, 2023, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2023.1149943

Biomolecule Conjugation Strategy for HAGM Cryogels to Create 3D Immune Niches that Induce Multifunctional T Cells

Author(s): Marjolein Schluck, Jorieke Weiden, Roel Hammink, Lea Weiss, M. Eloisa Vega Quiroz, Maren Pfirrmann, Laia Junquera Guinovart, Vincent van der Steen, Chadia Archidi, Leanne H. Minall, René Classens, Mahboobeh Rezaeeyazdi, Thibault Colombani, Sidi A. Bencherif, Carl G. Figdor, Martijn Verdoes
Published in: ACS Biomaterials Science & Engineering, Issue 11, 2025, Page(s) 4773-4787, ISSN 2373-9878
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.5c00134

Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Author(s): Weiss, L.; Weiden, J.; Dolen, Y.; Grad, E.M.; van Dinther, E.A.W.; Schluck, M.; Eggermont, L.J.; van Mierlo, G.; van Mierlo, G.; Gileadi, U.; Bartoló-Ibars, A.; Raavé, R.; Gorris, M.A.J.; Maassen, L.; Verrijp, K.; Valente, M.C.P.; Deplancke, B.; Verdoes, M.; Benitez-Ribas, D.; Heskamp, S.; van Spriel, A.B.; Figdor, C.G.; Hammink, R.
Published in: ACS Nano, 17, 13, pp. 12101-12117, Issue 6, 2023, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c11884

Artificial Antigen-Presenting Cell Topology Dictates T Cell Activation

Author(s): Wauters, A.C., Scheerstra, J.F., Vermeijlen, I.G., Hammink, R., Schluck, M., Woythe, L., Wu, H., Albertazzi, L., Figdor, C.G., Tel, J., Abdelmohsen, L., and van Hest, J.C.M.
Published in: ACS Nano, Issue 16, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c06211

Dictating Phenotype, Function, and Fate of Human T Cells with Co-Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics

Author(s): Schluck, M, Eggermont, LJ, Weiden, J, Popelier, C, Weiss, L, Pilzecker, B, Kolder, S, Heinemans, A, Mogeda, CR, Verdoes, M, Figdor, CG, Hammink, R.
Published in: Advanced Therapeutics, 2022, ISSN 2366-3987
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/adtp.202200019

Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells

Author(s): Lea Weiss, Marjolein Schluck, René Classens, Paul K.J.D. de Jonge, Anniek van der Waart, Khue G. Nguyen, Tam T. Nguyen, David A. Zaharoff, Karl-Johan Malmberg, Harry Dolstra, Carl G. Figdor, Ebba Sohlberg, Roel Hammink
Published in: Acta Biomaterialia, Issue 191, 2024, Page(s) 386-397, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2024.11.012

Semi‐Flexible Immunobrushes Facilitate Effective and Selective Expansion of Antigen‐Specific T Cells

Author(s): Lotte Gerrits, Lea Weiss, Emilia M. Grad, Marjolein Schluck, Lisa Maassen, René Classens, Chadia Archidi, Martijn Verdoes, Carl G. Figdor, Paul H. J. Kouwer, Roel Hammink
Published in: Advanced Functional Materials, Issue 34, 2024, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202307606

Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion

Author(s): Roel Hammink, Jorieke Weiden, Dion Voerman, Carlijn Popelier, Loek J. Eggermont, Marjolein Schluck, Carl G. Figdor, Martijn Verdoes
Published in: ACS Applied Materials & Interfaces, Issue 13/14, 2021, Page(s) 16007-16018, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.0c21994

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

Author(s): Di Blasio, S, van Wigcheren, GF, Becker, A, van Duffelen, A, Gorris, M, Verrijp, K, Stefanini, I, Bakker, GJ, Bloemendal, M, Halilovic, A, Vasaturo, A, Bakdash, G, Hato, SV, de Wilt, JHW, Schalkwijk, J, de Vries, IJM, Textor, JC, van den Bogaard, EH, Tazzari, M, Figdor, CG.
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16583-0

Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots.

Author(s): Jorieke Weiden; Marjolein Schluck; Melina Ioannidis; Eric A. W. van Dinther; Mahboobeh Rezaeeyazdi; Fawad Omar; Juulke Steuten; Dion Voerman; Jurjen Tel; Mustafa Diken; Sidi A. Bencherif; Carl G. Figdor; Martijn Verdoes
Published in: ACS Biomaterials Science & Engineering, Issue 2, 2021, ISSN 2373-9878
Publisher: ACS Publications
DOI: 10.1021/acsbiomaterials.0c01648

Immunofilaments Are Well Tolerated after Local or Systemic Administration in Mice

Author(s): Lea Weiss, René Classens, Marjolein Schluck, Emilia Grad, Yusuf Dölen, Lieke van der Woude, Dominique van Midden, Lisa Maassen, Kiek Verrijp, Koen van Riessen, Eric van Dinther, Philipp M. Hagemann, Carl G. Figdor, Roel Hammink
Published in: ACS Pharmacology & Translational Science, Issue 7, 2024, Page(s) 1874-1883, ISSN 2575-9108
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsptsci.4c00180