Project description
Cancer immunotherapy finds its niche
Activating an immune response to harmful pathogens requires the interaction of several types of immune cells. Specialised 'niches' found in lymph organs, inflammation sites and tumour microenvironments are the sites of this activity. ARTimmune is engineering very powerful synthetic immune niches to enhance cancer immunotherapy. Scientists will increase understanding of cellular interactions in lymph nodes, leading to the targeted design of powerful immunomodulating molecules. Then, like commandos with powerful weapons dropped into a target, the molecules will be injected into the lymph nodes along with a scaffold that encourages immune cell infiltration. Locally enhancing immune activity could prove more effective with far fewer side effects than conventional systemic immunotherapy, changing the prognoses for millions of cancer patients.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
6525 GA Nijmegen
Netherlands
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Beneficiaries (2)
6525 GA Nijmegen
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Participation ended
6525 XZ Nijmegen
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