Innovative technology to deliver large functional DNA circuitry into mammalian genomes
Gene editing is developing at breathtaking speed and is currently highly effective for local, small genomic DNA edits and insertions. Gene synthesis is now capable of producing thousands of DNA base pairs. The next challenge is genome engineering with the delivery of large multi-component DNA circuitry, including programmable functionalities. The EU-funded DNA-DOCK project aspires to create ground-breaking, easy-to-use technology to enable docking of large DNA cargos with base-pair precision into mammalian genomes, generating multifunctional circuits. Researchers will employ multiple sophisticated technologies to achieve these ambitious goals and accomplish precise DNA integration into specific genomic sites.
Fields of science
Funding SchemeERC-ADG - Advanced Grant
BS8 1QU Bristol
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