Project description
Is there a link between the gut microbiome and tumour immunity?
Emerging evidence indicates that tumour neoantigens are more likely to be immunogenic if they resemble infectious disease-associated antigens, because they are more likely to be recognised by a T cell. Extending from this observation, the EU-funded VACCIBIOME project aims to investigate the connection between cancer immunity and gut microbiome. The hypothesis is that peripheral T cells which process and present microbiome antigens also infiltrate tumours and cross-react with cancer antigens. Researchers will evaluate the molecular mimicry of gut microbiome and cancer antigens and delineate its importance in tumour immunity. Ultimately this is expected to lead to more effective anti-cancer vaccines.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
38122 Trento
Italy
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Beneficiaries (2)
38122 Trento
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53100 Siena
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