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Cancer Vaccines and Gut Microbiome: a rational approach to optimize cancer immunotherapy

Project description

Is there a link between the gut microbiome and tumour immunity?

Emerging evidence indicates that tumour neoantigens are more likely to be immunogenic if they resemble infectious disease-associated antigens, because they are more likely to be recognised by a T cell. Extending from this observation, the EU-funded VACCIBIOME project aims to investigate the connection between cancer immunity and gut microbiome. The hypothesis is that peripheral T cells which process and present microbiome antigens also infiltrate tumours and cross-react with cancer antigens. Researchers will evaluate the molecular mimicry of gut microbiome and cancer antigens and delineate its importance in tumour immunity. Ultimately this is expected to lead to more effective anti-cancer vaccines.

Host institution

UNIVERSITA DEGLI STUDI DI TRENTO
Net EU contribution
€ 962 500,00
Address
Via Calepina 14
38122 Trento
Italy

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Region
Nord-Est Provincia Autonoma di Trento Trento
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (2)

UNIVERSITA DEGLI STUDI DI TRENTO
Italy
Net EU contribution
€ 962 500,00
Address
Via Calepina 14
38122 Trento

See on map

Region
Nord-Est Provincia Autonoma di Trento Trento
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FONDAZIONE TOSCANA LIFE SCIENCES
Italy
Net EU contribution
€ 1 487 500,00
Address
Via Fiorentina 1
53100 Siena

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Region
Centro (IT) Toscana Siena
Activity type
Research Organisations
Other funding
€ 0,00