Project description
Innovative pancreatic islet transplantation platform for long-term diabetes treatment
Pancreatic islet transplantation is essential for diabetes treatment. The EU-funded EYELETS project aims to create a transferable platform for monitoring and treatment of insulin-dependent diabetes in mice. The objective is to combine tissue engineering of islet cell organoids, transplantation, synthetic biology and novel microelectronic/optical readout systems for islet cells. Researchers established the anterior chamber of the eye (ACE) as a favourable environment for the long-term survival of islet grafts and the cornea, as a natural window for non-invasive monitoring of islet function. ACE engrafted islets maintain blood glucose homeostasis in diabetic animals. The project will test the hypothesis that genetically engineered islet organoids are superior to native pancreatic islets to treat insulin-dependent diabetes.
Fields of science
- medical and health sciencesmedical biotechnologytissue engineering
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineophthalmology
- medical and health sciencesclinical medicinetransplantation
- medical and health sciencesbasic medicinephysiologyhomeostasis
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
17177 Stockholm
Sweden
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Beneficiaries (1)
17177 Stockholm
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