A regenerative medicine approach in diabetes.

Publications

Peer reviewed articles (21)

Challenges in stem cell-derived islet replacement therapy can be overcome

Author(s): MH Abdulreda, P-O Berggren
Published in: Cell Transplantation, 30, 2021, Page(s) 1-5, ISSN 1555-3892
Publisher: SAGE Publications
DOI: 10.1177/09636897211045320

Local Dexamethasone Administration Delays Allogeneic Islet Graft Rejection in the Anterior Chamber of the Eye of Non-Human Primates

Author(s): Sai Bo Bo Tun, Minni Chua, Gavin Siew Wei Tan, Ingo Leibiger, Yusuf Ali, Veluchamy Amutha Barathi, Per-Olof Berggren
Published in: Cell Transplantation, Volume 31, 2022, Page(s) 1-14, ISSN 0963-6897
Publisher: Cognizant Communication Corp.
DOI: 10.1177/09636897221098038

In vivo Ca 2+ dynamics in single pancreatic β cells

Author(s): Stefan Jacob, Martin Köhler, Philip Tröster, Montse Visa, Concha F. García‐Prieto, Tomas Alanentalo, Tilo Moede, Barbara Leibiger, Ingo B. Leibiger, Per‐Olof Berggren
Published in: The FASEB Journal, 34/1, 2020, Page(s) 945-959, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201901302rr

Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements

Author(s): Ismael Valladolid-Acebes, Karin Åvall, Patricia Recio-López, Noah Moruzzi, Galyna Bryzgalova, Marie Björnholm, Anna Krook, Elena Fauste Alonso, Madelene Ericsson, Fredrik Landfors, Stefan K. Nilsson, Per-Olof Berggren, Lisa Juntti-Berggren
Published in: Science Advances, 7/11, 2021, Page(s) eabc2931, ISSN 2375-2548
Publisher: AMER ASSOC ADVANCEMENT SCIENCE1200 NEW YORK AVE, NW, WASHINGTON, DC 20005
DOI: 10.1126/sciadv.abc2931

Intravital Ca 2+ imaging of pancreatic β cell function after bariatric surgery

Author(s): P Tröster, P-O Berggren
Published in: Cell Calcium, 104, 2022, ISSN 0143-4160
Publisher: Churchill Livingstone
DOI: 10.1016/j.ceca.2022.102566

XPR1 Mediates the Pancreatic beta-Cell Phosphate Flush

Author(s): Barker CJ, Tessaro FHG, Ferreira SS, Simas R, Ayala TS, Köhler M, Rajasekaran SS, Martins JO, Darè E, Berggren P-O
Published in: Diabetes, 70, 2020, Page(s) 111-18, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db19-0633

The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity

Author(s): Erwin Ilegems, Per-Olof Berggren
Published in: Frontiers in Endocrinology, 12, 2021, ISSN 1664-2392
Publisher: FRONTIERS MEDIA SAAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015
DOI: 10.3389/fendo.2021.652853

Inward and outward currents of native and cloned K(ATP) channels (Kir6.2/SUR1) share single-channel kinetic properties

Author(s): Robert Bränström , Erik Berglund, Robin Fröbom, Ingo B Leibiger, Barbara Leibiger, Craig A Aspinwall, Olof Larsson, Per-Olof Berggren
Published in: Biochemistry and Biophysics Reports, 30, 2022, ISSN 2405-5808
Publisher: Elsevier
DOI: 10.1016/j.bbrep.2022.101260

Alpha cell regulation of beta cell function

Author(s): Tilo Moede, Ingo B. Leibiger, Per-Olof Berggren
Published in: Diabetologia, 63/10, 2020, Page(s) 2064-2075, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05196-3

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

Author(s): Yan Xiong, M Julia Scerbo, Anett Seelig, Francesco Volta, Nils O'Brien, Andrea Dicker, Daniela Padula, Heiko Lickert, Jantje Mareike Gerdes, Per-Olof Berggren
Published in: eLife, 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.56914

Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models

Author(s): Noah Moruzzi, Francesca Lazzeri‐Barcelo, Ismael Valladolid‐Acebes, Tilo Moede, Meike Paschen, Barbara Leibiger, Per‐Olof Berggren, Ingo B. Leibiger
Published in: Journal of Cellular and Molecular Medicine, 25/10, 2021, Page(s) 4800-4813, ISSN 1582-1838
Publisher: Wiley-Blackwell
DOI: 10.1111/jcmm.16452

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes

Author(s): ZHENG X, HO QWC, CHUA M, STELMASHENKO O, YEO XY, MURALIDHARAN S, TORTA F, CHEW EGY, LIAN MM, FOO JN, JUNG S, WONG SH, TAN NS, TONG N, RUTTER AG, WENK MR, SILVER DL, BERGGREN P-O, ALI Y
Published in: Proc Natl Acad Sci, 119, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2113074119

Apolipoprotein CIII Is an Important Piece in the Type-1 Diabetes Jigsaw Puzzle

Author(s): Ismael Valladolid-Acebes, Per-Olof Berggren, Lisa Juntti-Berggren
Published in: International Journal of Molecular Sciences, 22/2, 2021, Page(s) 932, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020932

Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells

Author(s): Tilo Moede, Barbara Leibiger, Pilar Vaca Sanchez, Elisabetta Daré, Martin Köhler, Thusitha P. Muhandiramlage, Ingo B. Leibiger, Per-Olof Berggren
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-76863-z

Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells

Author(s): ZHAO K, SHI Y, YU J, YU L, MAEL A, LI Y, KOLTON A, JOYCE T, ODORICO J, BERGGREN P-O, YANG S-N
Published in: Cell Transplantation, 31, 2022, Page(s) 1-12, ISSN 0963-6897
Publisher: Cognizant Communication Corp.
DOI: 10.1177/09636897211066508

Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

Author(s): Joan Mir-Coll, Tilo Moede, Meike Paschen, Aparna Neelakandhan, Ismael Valladolid-Acebes, Barbara Leibiger, Adelinn Biernath, Carina Ämmälä, Ingo B. Leibiger, Burcak Yesildag, Per-Olof Berggren
Published in: International Journal of Molecular Sciences, 22/4, 2021, Page(s) 1813, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22041813

Apolipoprotein CIII Reduction Protects White Adipose Tissues against Obesity-Induced Inflammation and Insulin Resistance in Mice

Author(s): RECIO-LOPEZ P, VALLADOLID-ACEBES I, BERGGREN P-O, JUNTTI-BERGGREN L
Published in: International Journal of Molecular Science, 23, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23010062

The pancreatic islet: a micro-organ in control

Author(s): MH Abdulreda, P-O Berggren
Published in: CellR4, 9, 2021, ISSN 2329-7042
Publisher: Verduci International LLC
DOI: 10.32113/cellr4_20213_3093

Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive K + channels.

Author(s): Benjamin A. Heitz; Robert Bränström; Wei Yang; Yiding Huang; Tilo Moede; Ingo B. Leibiger; Barbara Leibiger; Liu Qi Chen; Jia Yu; Shao-Nian Yang; Olof Larsson; S. Scott Saavedra; Per Olof Berggren; Craig A. Aspinwall
Published in: ACS Nano, 2, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-00988-y

Enhanced expression of β cell Ca V 3.1 channels impairs insulin release and glucose homeostasis

Author(s): Jia Yu, Yue Shi, Kaixuan Zhao, Guang Yang, Lina Yu, Yuxin Li, Eva-Marie Andersson, Carina Ämmälä, Shao-Nian Yang, Per-Olof Berggren
Published in: Proceedings of the National Academy of Sciences, 117/1, 2020, Page(s) 448-453, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1908691117

Ectopic leptin production by intraocular islet organoids ameliorates the metabolic phenotype of ob/ob mice

Author(s): Leibiger B, Moede T, Valladolid-Acebes I, Paschen M, Visa M, Leibiger IB, Berggren P-O
Published in: Metabolites, 11, 2021, Page(s) 387, ISSN 2218-1989
Publisher: MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL
DOI: 10.3390/metabo11060387