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A regenerative medicine approach in diabetes.

Publications

In vivo Ca 2+ dynamics in single pancreatic β cells

Author(s): Stefan Jacob, Martin Köhler, Philip Tröster, Montse Visa, Concha F. García‐Prieto, Tomas Alanentalo, Tilo Moede, Barbara Leibiger, Ingo B. Leibiger, Per‐Olof Berggren
Published in: The FASEB Journal, Issue 34/1, 2020, Page(s) 945-959, ISSN 0892-6638
DOI: 10.1096/fj.201901302rr

Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements

Author(s): Ismael Valladolid-Acebes, Karin Åvall, Patricia Recio-López, Noah Moruzzi, Galyna Bryzgalova, Marie Björnholm, Anna Krook, Elena Fauste Alonso, Madelene Ericsson, Fredrik Landfors, Stefan K. Nilsson, Per-Olof Berggren, Lisa Juntti-Berggren
Published in: Science Advances, Issue 7/11, 2021, Page(s) eabc2931, ISSN 2375-2548
DOI: 10.1126/sciadv.abc2931

XPR1 Mediates the Pancreatic beta-Cell Phosphate Flush

Author(s): Barker CJ, Tessaro FHG, Ferreira SS, Simas R, Ayala TS, Köhler M, Rajasekaran SS, Martins JO, Darè E, Berggren P-O
Published in: Diabetes, Issue 70, 2020, Page(s) 111-18, ISSN 0012-1797
DOI: 10.2337/db19-0633

The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity

Author(s): Erwin Ilegems, Per-Olof Berggren
Published in: Frontiers in Endocrinology, Issue 12, 2021, ISSN 1664-2392
DOI: 10.3389/fendo.2021.652853

Alpha cell regulation of beta cell function

Author(s): Tilo Moede, Ingo B. Leibiger, Per-Olof Berggren
Published in: Diabetologia, Issue 63/10, 2020, Page(s) 2064-2075, ISSN 0012-186X
DOI: 10.1007/s00125-020-05196-3

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

Author(s): Yan Xiong, M Julia Scerbo, Anett Seelig, Francesco Volta, Nils O'Brien, Andrea Dicker, Daniela Padula, Heiko Lickert, Jantje Mareike Gerdes, Per-Olof Berggren
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
DOI: 10.7554/elife.56914

Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models

Author(s): Noah Moruzzi, Francesca Lazzeri‐Barcelo, Ismael Valladolid‐Acebes, Tilo Moede, Meike Paschen, Barbara Leibiger, Per‐Olof Berggren, Ingo B. Leibiger
Published in: Journal of Cellular and Molecular Medicine, Issue 25/10, 2021, Page(s) 4800-4813, ISSN 1582-1838
DOI: 10.1111/jcmm.16452

Apolipoprotein CIII Is an Important Piece in the Type-1 Diabetes Jigsaw Puzzle

Author(s): Ismael Valladolid-Acebes, Per-Olof Berggren, Lisa Juntti-Berggren
Published in: International Journal of Molecular Sciences, Issue 22/2, 2021, Page(s) 932, ISSN 1422-0067
DOI: 10.3390/ijms22020932

Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells

Author(s): Tilo Moede, Barbara Leibiger, Pilar Vaca Sanchez, Elisabetta Daré, Martin Köhler, Thusitha P. Muhandiramlage, Ingo B. Leibiger, Per-Olof Berggren
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-76863-z

Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

Author(s): Joan Mir-Coll, Tilo Moede, Meike Paschen, Aparna Neelakandhan, Ismael Valladolid-Acebes, Barbara Leibiger, Adelinn Biernath, Carina Ämmälä, Ingo B. Leibiger, Burcak Yesildag, Per-Olof Berggren
Published in: International Journal of Molecular Sciences, Issue 22/4, 2021, Page(s) 1813, ISSN 1422-0067
DOI: 10.3390/ijms22041813

Enhanced expression of β cell Ca V 3.1 channels impairs insulin release and glucose homeostasis

Author(s): Jia Yu, Yue Shi, Kaixuan Zhao, Guang Yang, Lina Yu, Yuxin Li, Eva-Marie Andersson, Carina Ämmälä, Shao-Nian Yang, Per-Olof Berggren
Published in: Proceedings of the National Academy of Sciences, Issue 117/1, 2020, Page(s) 448-453, ISSN 0027-8424
DOI: 10.1073/pnas.1908691117

Ectopic leptin production by intraocular islet organoids ameliorates the metabolic phenotype of ob/ob mice

Author(s): Leibiger B, Moede T, Valladolid-Acebes I, Paschen M, Visa M, Leibiger IB, Berggren P-O
Published in: Metabolites, Issue 11, 2021, Page(s) 387, ISSN 2218-1989
DOI: 10.3390/metabo11060387