A regenerative medicine approach in diabetes.

Información del proyecto

EYELETS

Identificador del acuerdo de subvención: 834860

DOI

10.3030/834860

Proyecto cerrado

Fecha de la firma de la CE 2 Mayo 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 30 Junio 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

KAROLINSKA INSTITUTET
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (43)

Challenges in stem cell-derived islet replacement therapy can be overcome

Autores: MH Abdulreda, P-O Berggren
Publicado en: Cell Transplantation, Edición 30, 2021, Página(s) 1-5, ISSN 1555-3892
Editor: SAGE Publications
DOI: 10.1177/09636897211045320

The anterior chamber of the eye technology and its anatomical, optical, and immunological bases

Autores: Shao-Nian Yang, Yue Shi, Per-Olof Berggren
Publicado en: Physiological Reviews, Edición 104, 2024, Página(s) 881-929, ISSN 0031-9333
Editor: American Physiological Society
DOI: 10.1152/physrev.00024.2023

Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII

Autores: Patricia Recio‐López, Ismael Valladolid‐Acebes, Philipp Hadwiger, Markus Hossbach, Monika Krampert, Carla Prata, Per‐Olof Berggren, Lisa Juntti‐Berggren
Publicado en: BioFactors, Edición 49, 2023, Página(s) 153-172, ISSN 0951-6433
Editor: International Union of Biochemistry by IRL Press
DOI: 10.1002/biof.1885

Target-Mediated EV-SNA Clustering as an Amplifier for <i>In Situ</i> miRNA Imaging in Living Cells

Autores: Zhenghao Wang, Xinyue Zhu, Ye Zhou, Tianci Zhang, Yue Shi, Xiaofeng Zheng, Shao-Nian Yang, Wei Li, Per-Olof Berggren
Publicado en: Nano Letters, Edición 25, 2025, Página(s) 11860-11869, ISSN 1530-6984
Editor: American Chemical Society
DOI: 10.1021/acs.nanolett.5c02256

Biodegradable and Antioxidant DNA Hydrogel as a Cytokine Delivery System for Diabetic Wound Healing

Autores: Zhenghao Wang, Wei Li, Liping Gou, Ye Zhou, Ge Peng, Jiayi Zhang, Jiaye Liu, Ruoqing Li, Hengfan Ni, Wanli Zhang, Ting Cao, Qi Cao, Hong Su, Yuan‐Ping Han, Nanwei Tong, Xianghui Fu, Erwin Ilegems, Yanrong Lu, Per‐Olof Berggren, Xiaofeng Zheng, Chengshi Wang
Publicado en: Advanced Healthcare Materials, Edición 11, 2025, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202200782

Local Dexamethasone Administration Delays Allogeneic Islet Graft Rejection in the Anterior Chamber of the Eye of Non-Human Primates

Autores: Sai Bo Bo Tun, Minni Chua, Gavin Siew Wei Tan, Ingo Leibiger, Yusuf Ali, Veluchamy Amutha Barathi, Per-Olof Berggren
Publicado en: Cell Transplantation, Edición Volume 31, 2022, Página(s) 1-14, ISSN 0963-6897
Editor: Cognizant Communication Corp.
DOI: 10.1177/09636897221098038

In vivo Ca 2+ dynamics in single pancreatic β cells

Autores: Stefan Jacob, Martin Köhler, Philip Tröster, Montse Visa, Concha F. García‐Prieto, Tomas Alanentalo, Tilo Moede, Barbara Leibiger, Ingo B. Leibiger, Per‐Olof Berggren
Publicado en: The FASEB Journal, Edición 34/1, 2020, Página(s) 945-959, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201901302rr

Lowering apolipoprotein CIII protects against high-fat diet–induced metabolic derangements

Autores: Ismael Valladolid-Acebes, Karin Åvall, Patricia Recio-López, Noah Moruzzi, Galyna Bryzgalova, Marie Björnholm, Anna Krook, Elena Fauste Alonso, Madelene Ericsson, Fredrik Landfors, Stefan K. Nilsson, Per-Olof Berggren, Lisa Juntti-Berggren
Publicado en: Science Advances, Edición 7/11, 2021, Página(s) eabc2931, ISSN 2375-2548
Editor: AMER ASSOC ADVANCEMENT SCIENCE1200 NEW YORK AVE, NW, WASHINGTON, DC 20005
DOI: 10.1126/sciadv.abc2931

Intravital Ca 2+ imaging of pancreatic β cell function after bariatric surgery

Autores: P Tröster, P-O Berggren
Publicado en: Cell Calcium, Edición 104, 2022, ISSN 0143-4160
Editor: Churchill Livingstone
DOI: 10.1016/j.ceca.2022.102566

In Vivo Imaging of Liver Spheroids Engrafted in the Anterior Chamber of the Mouse Eye

Autores: Francesca Lazzeri-Barcelo, Pierpaolo Ciardo, Barbara Leibiger, Ingo B. Leibiger, Per-Olof Berggren, Noah Moruzzi
Publicado en: Journal of Visualized Experiments, 2024, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/66234

Transplantation and Noninvasive Longitudinal <i>In Vivo</i> Imaging of Parathyroid Cells: A Proof-of-Concept Study

Autores: Robert Bränström, Pim P. van Krieken, Robin Fröbom, C. Christofer Juhlin, Ivan Shabo, Barbara Leibiger, Ingo B. Leibiger, Per-Olof Berggren, Craig A. Aspinwall
Publicado en: Cell Transplantation, Edición 33, 2025, ISSN 0963-6897
Editor: Cognizant Communication Corp.
DOI: 10.1177/09636897241241995

XPR1 Mediates the Pancreatic beta-Cell Phosphate Flush

Autores: Barker CJ, Tessaro FHG, Ferreira SS, Simas R, Ayala TS, Köhler M, Rajasekaran SS, Martins JO, Darè E, Berggren P-O
Publicado en: Diabetes, Edición 70, 2020, Página(s) 111-18, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db19-0633

The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity

Autores: Erwin Ilegems, Per-Olof Berggren
Publicado en: Frontiers in Endocrinology, Edición 12, 2021, ISSN 1664-2392
Editor: FRONTIERS MEDIA SAAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015
DOI: 10.3389/fendo.2021.652853

In Vivo CaV3 Channel Inhibition Promotes Maturation of Glucose-Dependent Ca2+ Signaling in Human iPSC-Islets

Autores: Kaixuan Zhao, Yue Shi, Jia Yu, Lina Yu, Martin Köhler, Amber Mael, Anthony Kolton, Thomas Joyce, Jon Odorico, Per-Olof Berggren, Shao-Nian Yang
Publicado en: Biomedicines, Edición 11, 2025, Página(s) 807, ISSN 2227-9059
Editor: MDPI AG
DOI: 10.3390/biomedicines11030807

Inward and outward currents of native and cloned K(ATP) channels (Kir6.2/SUR1) share single-channel kinetic properties

Autores: Robert Bränström , Erik Berglund, Robin Fröbom, Ingo B Leibiger, Barbara Leibiger, Craig A Aspinwall, Olof Larsson, Per-Olof Berggren
Publicado en: Biochemistry and Biophysics Reports, Edición 30, 2022, ISSN 2405-5808
Editor: Elsevier
DOI: 10.1016/j.bbrep.2022.101260

HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes

Autores: Erwin Ilegems, Galyna Bryzgalova, Jorge Correia, Burcak Yesildag, Edurne Berra, Jorge L. Ruas, Teresa S. Pereira, Per-Olof Berggren
Publicado en: Science Translational Medicine, Edición 14, 2024, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aba9112

Alpha cell regulation of beta cell function

Autores: Tilo Moede, Ingo B. Leibiger, Per-Olof Berggren
Publicado en: Diabetologia, Edición 63/10, 2020, Página(s) 2064-2075, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-020-05196-3

β-Cell Neogenesis From the Pancreatic Ductal Epithelium Revealed Dynamically by Long-term Intravital Imaging

Autores: Brandon Watts, Isabella Altilio, Óscar Alcázar, Silvia Álvarez-Cubela, Per-Olof Berggren, Midhat H. Abdulreda, Ricardo L. Pastori, Juan Domínguez-Bendala
Publicado en: Diabetes, 2025, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db25-0457

Sustained heterologous gene expression in pancreatic islet organoids using adeno-associated virus serotype 8

Autores: Anna Voznesenskaya, Per-Olof Berggren, Erwin Ilegems
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 11, 2023, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1147244

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

Autores: Yan Xiong, M Julia Scerbo, Anett Seelig, Francesco Volta, Nils O'Brien, Andrea Dicker, Daniela Padula, Heiko Lickert, Jantje Mareike Gerdes, Per-Olof Berggren
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.56914

Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells

Autores: Kim Olesen, Noah Moruzzi, Ivana Bulatovic, Clifford Folmes, Ryounghoon Jeon, Ulrika Felldin, Andre Terzic, Oscar E. Simonson, Katarina Le Blanc, Cecilia Österholm, Per-Olof Berggren, Tomas Schiffer, Sergey Rodin, Andreas Tilevik, Karl-Henrik Grinnemo
Publicado en: Metabolism Open, Edición 13, 2022, Página(s) 100167, ISSN 2589-9368
Editor: Elsevier BV
DOI: 10.1016/j.metop.2022.100167

Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models

Autores: Noah Moruzzi, Francesca Lazzeri‐Barcelo, Ismael Valladolid‐Acebes, Tilo Moede, Meike Paschen, Barbara Leibiger, Per‐Olof Berggren, Ingo B. Leibiger
Publicado en: Journal of Cellular and Molecular Medicine, Edición 25/10, 2021, Página(s) 4800-4813, ISSN 1582-1838
Editor: Wiley-Blackwell
DOI: 10.1111/jcmm.16452

XPR1 mediates the pancreatic β-cell phosphate flush

Autores: Ada Admin, Christopher J. Barker, Fernando Henrique Galvão Tessaro, Sabrina de Souza Ferreira, Rafael Simas, Thais S. Ayala, Martin Köhler, Subu Surendran Rajasekaran, Joilson O. Martins, Elisabetta Darè, Per Olof Berggren
Publicado en: Diabetes, Edición Vol 33, 2020, ISSN 0963-6897
Editor: Cognizant Communication Corp.
DOI: 10.2337/figshare.12821192.v1

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Autores: Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per-Olof Berggren, Christopher J. Barker
Publicado en: Biomolecules, Edición 13, 2025, Página(s) 885, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom13060885

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes

Autores: ZHENG X, HO QWC, CHUA M, STELMASHENKO O, YEO XY, MURALIDHARAN S, TORTA F, CHEW EGY, LIAN MM, FOO JN, JUNG S, WONG SH, TAN NS, TONG N, RUTTER AG, WENK MR, SILVER DL, BERGGREN P-O, ALI Y
Publicado en: Proc Natl Acad Sci, Edición 119, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2113074119

Apolipoprotein CIII Is an Important Piece in the Type-1 Diabetes Jigsaw Puzzle

Autores: Ismael Valladolid-Acebes, Per-Olof Berggren, Lisa Juntti-Berggren
Publicado en: International Journal of Molecular Sciences, Edición 22/2, 2021, Página(s) 932, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020932

Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells

Autores: Tilo Moede, Barbara Leibiger, Pilar Vaca Sanchez, Elisabetta Daré, Martin Köhler, Thusitha P. Muhandiramlage, Ingo B. Leibiger, Per-Olof Berggren
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-76863-z

3D‐Printed Biohybrid Microstructures Enable Transplantation and Vascularization of Microtissues in the Anterior Chamber of the Eye

Autores: Hanie Kavand, Montse Visa, Martin Köhler, Wouter van der Wijngaart, Per‐Olof Berggren, Anna Herland
Publicado en: Advanced Materials, Edición 36, 2025, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202306686

Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function

Autores: Francesca Lazzeri-Barcelo, Nuria Oliva-Vilarnau, Marion Baniol, Barbara Leibiger, Olaf Bergmann, Volker M. Lauschke, Ingo B. Leibiger, Noah Moruzzi, Per-Olof Berggren
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-45122-4

Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells

Autores: ZHAO K, SHI Y, YU J, YU L, MAEL A, LI Y, KOLTON A, JOYCE T, ODORICO J, BERGGREN P-O, YANG S-N
Publicado en: Cell Transplantation, Edición 31, 2022, Página(s) 1-12, ISSN 0963-6897
Editor: Cognizant Communication Corp.
DOI: 10.1177/09636897211066508

Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

Autores: Joan Mir-Coll, Tilo Moede, Meike Paschen, Aparna Neelakandhan, Ismael Valladolid-Acebes, Barbara Leibiger, Adelinn Biernath, Carina Ämmälä, Ingo B. Leibiger, Burcak Yesildag, Per-Olof Berggren
Publicado en: International Journal of Molecular Sciences, Edición 22/4, 2021, Página(s) 1813, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22041813

Apolipoprotein CIII Reduction Protects White Adipose Tissues against Obesity-Induced Inflammation and Insulin Resistance in Mice

Autores: RECIO-LOPEZ P, VALLADOLID-ACEBES I, BERGGREN P-O, JUNTTI-BERGGREN L
Publicado en: International Journal of Molecular Science, Edición 23, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23010062

Alpha-to-beta cell crosstalk: Adaptive mechanisms shaping islet function

Autores: Philip Tröster, Montse Visa, Per-Olof Berggren
Publicado en: Advances in Biological Regulation, 2025, Página(s) 101121, ISSN 2212-4926
Editor: Elsevier BV
DOI: 10.1016/j.jbior.2025.101121

The pancreatic islet: a micro-organ in control

Autores: MH Abdulreda, P-O Berggren
Publicado en: CellR4, Edición 9, 2021, ISSN 2329-7042
Editor: Verduci International LLC
DOI: 10.32113/cellr4_20213_3093

Quantitative 3D OPT and LSFM datasets of pancreata from mice with streptozotocin-induced diabetes

Autores: Max Hahn, Christoffer Nord, Pim P. van Krieken, Per-Olof Berggren, Erwin Ilegems, Abbas Cheddad, Ulf Ahlgren
Publicado en: Scientific Data, Edición 9, 2022, ISSN 2052-4463
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41597-022-01546-5

Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca2+ dynamics in prediabetic beta cells

Autores: Montse Visa, Per-Olof Berggren
Publicado en: Diabetologia, Edición 67, 2024, Página(s) 1663-1682, ISSN 0012-186X
Editor: Springer Verlag
DOI: 10.1007/s00125-024-06173-w

Expression of truncated Kir6.2 promotes insertion of functionally inverted ATP-sensitive K + channels.

Autores: Benjamin A. Heitz; Robert Bränström; Wei Yang; Yiding Huang; Tilo Moede; Ingo B. Leibiger; Barbara Leibiger; Liu Qi Chen; Jia Yu; Shao-Nian Yang; Olof Larsson; S. Scott Saavedra; Per Olof Berggren; Craig A. Aspinwall
Publicado en: ACS Nano, Edición 2, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-00988-y

Novel aspects of intra-islet communication: Primary cilia and filopodia

Autores: Noah Moruzzi, Barbara Leibiger, Christopher J. Barker, Ingo B. Leibiger, Per-Olof Berggren
Publicado en: Advances in Biological Regulation, Edición 87, 2025, Página(s) 100919, ISSN 2212-4926
Editor: Elsevier BV
DOI: 10.1016/j.jbior.2022.100919

Diet-induced obesity promotes endothelial cell desensitization to VEGF-A and permanent islet vessel dysfunction in mice

Autores: Yan Xiong, Andrea Dicker, Montse Visa, Erwin Ilegems, Per-Olof Berggren
Publicado en: Journal of Clinical Investigation, Edición 135, 2025, ISSN 1558-8238
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci177601

Enhanced expression of β cell Ca V 3.1 channels impairs insulin release and glucose homeostasis

Autores: Jia Yu, Yue Shi, Kaixuan Zhao, Guang Yang, Lina Yu, Yuxin Li, Eva-Marie Andersson, Carina Ämmälä, Shao-Nian Yang, Per-Olof Berggren
Publicado en: Proceedings of the National Academy of Sciences, Edición 117/1, 2020, Página(s) 448-453, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1908691117

Ectopic leptin production by intraocular islet organoids ameliorates the metabolic phenotype of ob/ob mice

Autores: Leibiger B, Moede T, Valladolid-Acebes I, Paschen M, Visa M, Leibiger IB, Berggren P-O
Publicado en: Metabolites, Edición 11, 2021, Página(s) 387, ISSN 2218-1989
Editor: MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL
DOI: 10.3390/metabo11060387

Islet environment and development of type 1 diabetes in the biobreeding rat model

Autores: Patricia Recio-López, Per-Olof Berggren, Montserrat Visa Majoral, Ismael Valladolid-Acebes, Lisa Juntti-Berggren
Publicado en: Signal Transduction and Targeted Therapy, Edición 10, 2025, ISSN 2059-3635
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41392-025-02330-8

Longitudinal monitoring of pancreatic islet damage in streptozotocin-treated mice with optical coherence microscopy

Autores: Won Yeong Park, Jaeyoon Kim, Hoan Le, Bumju Kim, Per-Olof Berggren, Ki Hean Kim
Publicado en: Biomedical Optics Express, Edición 14, 2024, Página(s) 54, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.470188

Book chapters (1)

Uncommon Transplantation Sites: Transplantation of Islets and Islet Organoids in the Anterior Chamber of the Eye of Rodents and Monkeys

Autores: Tilo Moede, Sai Bo Bo Tun, Ingo B. Leibiger, Per-Olof Berggren
Publicado en: Methods in Molecular Biology, Type-1 Diabetes, 2022, Página(s) 21-36
Editor: Springer US
DOI: 10.1007/978-1-0716-2807-2_2