A significant part of the research work has been focused on the design and synthesis of second-generation catalysts based on Johnphos ligands modified with a C2-chiral pyrrolidine subunit as well as related complexes based on chiral planar ferrocene ligands. These catalysts have allowed to develop an atroposelective synthesis of aryl-substituted indole derivatives. A new family of catalysts with ligands bearing urea, thiourea, and squaramide subunits have been developed for the silver-free gold-catalyzed activation of alkynes and the enantioselective folding of unsaturated substrates. Small gold(I) and gold(I)-silver(I) clusters have also been synthesized for the activation of alkynes. We have also studied alternative catalysts based on metals different from gold (such as rhodium and zinc), along the goals of the.
We have also reported the first activation of acetylene gas catalyzed by gold and are now studying the oligomerization and polymerization acetylene gas under very mild conditions as well as other reactions of simple acetylenes. Finally, new digold chiral cavitand complexes have been developed and other bimetallic catalysts (Au/Cu, Au/Ru) are under development.