Periodic Reporting for period 1 - ReMyelin (The Cell Biology of Remyelination)
Période du rapport: 2019-04-01 au 2021-09-30
In this project, I have examined the potential intrinsic and extrinsic influences on myelin sheath formation and maturation in young and adult oligodendroglia to which the results will have extensive applications. Nearly all available in vitro data on myelin sheath formation are derived from oligodendroglia isolated from heathy neonates, and few studies have attempted to distinguish between intrinsic (glial) and extrinsic (axonal) myelinating cues in the context of remyelination.