Project description
MicroRNA-based diagnostics via DNA computers
Changes in microRNA levels are associated with human diseases, and their monitoring enables clinicians to perform diagnosis and evaluate the therapeutic efficacy of drugs. DNA computing represents an emerging technology that uses DNA, biochemistry and molecular biology hardware instead of the traditional silicon-based technologies. The EU-funded DNACom project will establish the proof-of-concept of compartmentalised DNA computers for in vitro molecular diagnostics and validate the commercial application of compartmentalised DNA circuits as point-of-care devices for the detection and classification of microRNA signatures. The project will capitalise on the partners' development of compartmentalised DNA-based molecular computers inside semipermeable micro-compartments made from a bovine serum albumin–polymer conjugate. The platform is capable of distributed sensing and processing of DNA and RNA strands.
Fields of science
Programme(s)
Funding Scheme
ERC-POC - Proof of Concept GrantHost institution
5612 AE Eindhoven
Netherlands
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Beneficiaries (1)
5612 AE Eindhoven
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