Bacterial membrane vesicles tackle antibiotic resistance
The emergence of antibiotic resistance alongside the very few drugs in the development pipeline means that gram-negative bacteria are now high on the list of medical priorities. The EU-funded BacDrug project proposes to overcome the barrier of the highly selective outer membrane of gram-negative pathogens through lipid-based bacterial membrane vesicles (BMVs). BMVs are produced by non-pathogenic Lactococcus lactis and serve as a delivery system for drugs. Due to their nanoscale size, BMVs can pass through the bacterial membrane and kill drug-resistant gram-negative pathogens. This therapeutic approach has the potential to tackle antibiotic resistance, with obvious benefits for human health.
Fields of science
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinemedicinal chemistry
- medical and health sciencesmedical biotechnologygenetic engineering
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance