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Bacterial membrane vesicles a novel delivery system for the treatment of multi-drug resistant Gram-negative bacterial infections.

Project description

Bacterial membrane vesicles tackle antibiotic resistance

The emergence of antibiotic resistance alongside the very few drugs in the development pipeline means that gram-negative bacteria are now high on the list of medical priorities. The EU-funded BacDrug project proposes to overcome the barrier of the highly selective outer membrane of gram-negative pathogens through lipid-based bacterial membrane vesicles (BMVs). BMVs are produced by non-pathogenic Lactococcus lactis and serve as a delivery system for drugs. Due to their nanoscale size, BMVs can pass through the bacterial membrane and kill drug-resistant gram-negative pathogens. This therapeutic approach has the potential to tackle antibiotic resistance, with obvious benefits for human health.

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Net EU contribution
€ 212 933,76
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 212 933,76