Descrizione del progetto
Vescicole di membrana batterica contro la resistenza agli antibiotici
L’emergere della resistenza agli antibiotici e i pochissimi farmaci nel ciclo di sviluppo sono problematiche attuali che posizionano i batteri gram-negativi in cima alla lista delle priorità mediche. Il progetto BacDrug, finanziato dall’UE, propone di superare la barriera della membrana esterna altamente selettiva dei patogeni gram-negativi attraverso vescicole di membrana batterica basate su lipidi. Le vescicole di membrana batterica sono prodotte dal Lactococcus lactis non patogeno e fungono da vettore per i farmaci. Date le loro dimensioni nanometriche, tali vescicole possono passare attraverso la membrana batterica e uccidere gli agenti patogeni gram-negativi resistenti ai farmaci. Questo approccio terapeutico ha il potenziale per affrontare il problema della resistenza agli antibiotici, con ovvi benefici per la salute umana.
Obiettivo
"Bacterial infections are a significant public health challenge and a major cause of human mortality globally. Antibiotics are indispensable for the treatment and prevention of infections caused by bacteria. However, global spread of drug-resistant bacteria, coupled with a dearth of new antibiotics in development has led to an alarming shortage of effective drugs. Gram-negative bacteria, in particular, protect themselves against antibiotics with a highly selective outer membrane. The high burden of diseases caused by Gram-negative bacteria, combined with their frequent multi-drug resistance has placed them as world´s highest-priority pathogens by the World Health Organization. Consequently, there is an urgent need for novel therapeutic approaches that combat Gram-negative bacterial pathogens. The goal of ""BacDrug"" is to use lipid-based bacterial membrane vesicles (BMVs) produced by non-pathogenic Lactococcus lactis as delivery system. BMVs have great potential as nanocarriers to by-pass the outer membrane and deliver their toxic payload to kill drug-resistant Gram-negative pathogens. A range of strategies will be used to load BMVs with cargo, including genetic engineering of L. lactis as well as chemical treatments. This Fellowship will harness expertise and techniques across microbiology, molecular biology, nanotechnology and drug design to deliver a successful outcome. The collaborative, truly interdisciplinary, cross faculty setting within the groups of Prof Molly Stevens (materials and bioengineering) and Dr Andrew Edwards (molecular microbiology) at ICL combines world-class expertise and provides an environment to maximise the success of this Fellowship, both in terms of the delivering the project and the training opportunities provided. Moreover, this innovative, alternative strategy to tackle drug-resistant Gram-negative bacterial infections has a high translational potential, which will be exploited via the clinical and translational research clinics at ICL."
Campo scientifico
- medical and health scienceshealth sciencespublic health
- medical and health sciencesbasic medicinemedicinal chemistry
- medical and health sciencesmedical biotechnologygenetic engineering
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF-EF-ST - Standard EFCoordinatore
SW7 2AZ LONDON
Regno Unito