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Constructing an evolutionary atlas of the immune landscape in lung cancer

Project description

Cancer evolution and microenvironment under the pressure of immune response

The interplay between the evolving genetics of tumour cells and the continuous selective pressure of the immune response is poorly understood. A better understanding of changes in the tumour microenvironment during cancer evolution may help to create an evolutionary rulebook for the rational and personalised design of combination immunotherapies for cancer. The EU-funded TRACERxTME project aims to integrate detailed genomic information from a multi-region longitudinal study of > 5 000 tumour regions from 842 lung cancer patients with a highly multiplexed tumour microenvironment. The imaging mass cytometry data will uncover the dynamics of distinct microenvironmental cell types during cancer progression and will ultimately inform the design of innovative precision medicine for lung cancer.

Coordinator

THE FRANCIS CRICK INSTITUTE LIMITED
Net EU contribution
€ 212 933,76
Address
1 Midland Road
NW1 1AT London
United Kingdom

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Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Other funding
€ 212 933,76