A more efficient method to produce nitrogen-based compounds
Nitrogen-containing ring structures (heterocycles) are widely used in the pharmaceutical and agrochemical industries. New methods to prepare them more efficiently and with greater flexibility are needed. Recently, ‘nucleophilic nitrenoids’ have rapidly emerged as highly effective reactants for the assembly of different nitrogen-containing heterocycles. The reactivity and selectivity of this method depends on the combination of gold catalysis and highly reactive species called donor-activated alkynes. Funded by the Marie Skłodowska-Curie Actions programme, the SEAROX project will develop a more general method for preparing nitrogen-based heterocycles. By demonstrating the ability of sulfur-based directing groups to impart unprecedented regioselectivity to intermolecular reactions, the project will take the nitrenoid method beyond the limitations of donor-activated alkynes and will significantly impact the gold catalysis field.
Fields of science
Call for proposalSee other projects for this call
Funding SchemeMSCA-IF-EF-ST - Standard EF
B15 2TT Birmingham
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